ID TM251_XENTR Reviewed; 162 AA.
AC Q5HZT8; A0JPC2; Q28GR7;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2009, sequence version 2.
DT 15-MAR-2017, entry version 60.
DE RecName: Full=Transmembrane protein 251;
GN Name=tmem251; ORFNames=TEgg078g21.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Egg;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=N6; TISSUE=Lung;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5HZT8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5HZT8-2; Sequence=VSP_036174;
CC -!- SIMILARITY: Belongs to the TMEM251 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH88890.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
CC Sequence=AAI27356.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
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DR EMBL; CR761254; CAJ82061.1; -; mRNA.
DR EMBL; BC088890; AAH88890.1; ALT_INIT; mRNA.
DR EMBL; BC127355; AAI27356.1; ALT_INIT; mRNA.
DR RefSeq; NP_001032343.1; NM_001037266.1.
DR RefSeq; XP_012823780.1; XM_012968326.2. [Q5HZT8-1]
DR UniGene; Str.4165; -.
DR PaxDb; Q5HZT8; -.
DR GeneID; 497000; -.
DR KEGG; xtr:497000; -.
DR CTD; 26175; -.
DR Xenbase; XB-GENE-971513; tmem251.
DR eggNOG; ENOG410IVYY; Eukaryota.
DR eggNOG; ENOG4111FFW; LUCA.
DR HOGENOM; HOG000111822; -.
DR HOVERGEN; HBG058826; -.
DR InParanoid; Q5HZT8; -.
DR OrthoDB; EOG091G14P1; -.
DR TreeFam; TF332722; -.
DR Proteomes; UP000008143; Unassembled WGS sequence.
DR Bgee; ENSXETG00000027035; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR028024; TMEM251.
DR Pfam; PF15190; TMEM251; 1.
DR ProDom; PD641273; PD641273; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1 162 Transmembrane protein 251.
FT /FTId=PRO_0000359888.
FT TRANSMEM 39 59 Helical. {ECO:0000255}.
FT TRANSMEM 97 117 Helical. {ECO:0000255}.
FT VAR_SEQ 1 31 Missing (in isoform 2).
FT {ECO:0000303|Ref.1}.
FT /FTId=VSP_036174.
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CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 33 160 ipfam:TMEM251 [T]
SQ SEQUENCE 162 AA; 18945 MW; 12FD421182C04B2E CRC64;
MWRVEFVACL RPSCQFCTAM CSILSAGRAW RMMNFRQRMG WIGVSLYLFV SAAAFYYVFE
INETYNRLAL EHVQLKPQEP HRGTTWTHSL KARLLSLPFW LWAALFLIPY FQVFLFLYSC
TRADPKTVGY CIIPICLAII CNRHQSFVKA SNQISRLQLI DT
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