Entry euk:TM251_HUMAN

ID   TM251_HUMAN             Reviewed;         163 AA.
AC   Q8N6I4; J3KQ65; Q9Y4S5;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 4.
DT   12-APR-2017, entry version 107.
DE   RecName: Full=Transmembrane protein 251;
GN   Name=TMEM251; Synonyms=C14orf109;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Embryonic brain;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA   Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA   Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA   Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA   Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA   Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA   Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA   Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA   Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA   Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA   Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA   Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA   Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA   Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA   Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA   Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA   Quetier F., Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-149 (ISOFORM 1).
RC   TISSUE=Brain, and Melanoma;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q8N6I4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8N6I4-2; Sequence=VSP_036175;
CC       Name=3;
CC         IsoId=Q8N6I4-3; Sequence=VSP_045689;
CC         Note=No experimental confirmation available.;
CC   -!- SIMILARITY: Belongs to the TMEM251 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH30119.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
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DR   EMBL; AL080118; CAB45717.2; -; mRNA.
DR   EMBL; AL110118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471061; EAW81518.1; -; Genomic_DNA.
DR   EMBL; BC030119; AAH30119.2; ALT_INIT; mRNA.
DR   EMBL; BM554490; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; CX785861; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS41980.1; -. [Q8N6I4-2]
DR   CCDS; CCDS45158.1; -. [Q8N6I4-3]
DR   PIR; T12454; T12454.
DR   RefSeq; NP_001092091.1; NM_001098621.1. [Q8N6I4-3]
DR   RefSeq; NP_056491.1; NM_015676.1. [Q8N6I4-2]
DR   UniGene; Hs.275352; -.
DR   UniGene; Hs.648806; -.
DR   STRING; 9606.ENSP00000388431; -.
DR   DMDM; 221222535; -.
DR   PaxDb; Q8N6I4; -.
DR   PeptideAtlas; Q8N6I4; -.
DR   PRIDE; Q8N6I4; -.
DR   Ensembl; ENST00000283534; ENSP00000283534; ENSG00000153485. [Q8N6I4-2]
DR   Ensembl; ENST00000415050; ENSP00000388431; ENSG00000153485. [Q8N6I4-3]
DR   Ensembl; ENST00000622205; ENSP00000478917; ENSG00000275947. [Q8N6I4-3]
DR   Ensembl; ENST00000626767; ENSP00000486678; ENSG00000275947. [Q8N6I4-2]
DR   GeneID; 26175; -.
DR   KEGG; hsa:26175; -.
DR   UCSC; uc001ybk.4; human. [Q8N6I4-1]
DR   CTD; 26175; -.
DR   GeneCards; TMEM251; -.
DR   H-InvDB; HIX0011913; -.
DR   HGNC; HGNC:20218; TMEM251.
DR   HPA; HPA048559; -.
DR   neXtProt; NX_Q8N6I4; -.
DR   OpenTargets; ENSG00000153485; -.
DR   PharmGKB; PA134977710; -.
DR   eggNOG; ENOG410IVYY; Eukaryota.
DR   eggNOG; ENOG4111FFW; LUCA.
DR   GeneTree; ENSGT00390000007473; -.
DR   HOGENOM; HOG000111822; -.
DR   HOVERGEN; HBG058826; -.
DR   InParanoid; Q8N6I4; -.
DR   OMA; LPFWFWT; -.
DR   OrthoDB; EOG091G14P1; -.
DR   PhylomeDB; Q8N6I4; -.
DR   TreeFam; TF332722; -.
DR   GenomeRNAi; 26175; -.
DR   PRO; PR:Q8N6I4; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   Bgee; ENSG00000153485; -.
DR   CleanEx; HS_C14orf109; -.
DR   Genevisible; Q8N6I4; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR028024; TMEM251.
DR   Pfam; PF15190; TMEM251; 1.
DR   ProDom; PD641273; PD641273; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    163       Transmembrane protein 251.
FT                                /FTId=PRO_0000089916.
FT   TRANSMEM     40     60       Helical. {ECO:0000255}.
FT   TRANSMEM     98    118       Helical. {ECO:0000255}.
FT   VAR_SEQ       1     32       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334,
FT                                ECO:0000303|PubMed:17974005}.
FT                                /FTId=VSP_036175.
FT   VAR_SEQ       1      1       M -> MLAFSEM (in isoform 3).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_045689.
FT   CONFLICT    152    153       SN -> FY (in Ref. 4; BM554490).
FT                                {ECO:0000305}.
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CC   The following FT lines are automated annotations from the MyHits database.
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FT   MYHIT        34    161       ipfam:TMEM251 [T]
SQ   SEQUENCE   163 AA;  18747 MW;  805D11CD73B20650 CRC64;
     MPKPPDYSEL SDSLTLAVGT GRFSGPLHRA WRMMNFRQRM GWIGVGLYLL ASAAAFYYVF
     EISETYNRLA LEHIQQHPEE PLEGTTWTHS LKAQLLSLPF WVWTVIFLVP YLQMFLFLYS
     CTRADPKTVG YCIIPICLAV ICNRHQAFVK ASNQISRLQL IDT
//