ID TM247_MOUSE Reviewed; 211 AA.
AC Q497K7; Q8BVQ7; Q9CU05;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 2.
DT 10-MAY-2017, entry version 68.
DE RecName: Full=Transmembrane protein 247;
GN Name=Tmem247;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and
RT expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI00487.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
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DR EMBL; AK018916; BAB31481.1; -; mRNA.
DR EMBL; AK076910; BAC36525.1; -; mRNA.
DR EMBL; BC100486; AAI00487.1; ALT_INIT; mRNA.
DR CCDS; CCDS79579.1; -.
DR RefSeq; NP_001264909.1; NM_001277980.1.
DR RefSeq; NP_084380.1; NM_030104.1.
DR UniGene; Mm.67234; -.
DR ProteinModelPortal; Q497K7; -.
DR iPTMnet; Q497K7; -.
DR PhosphoSitePlus; Q497K7; -.
DR PaxDb; Q497K7; -.
DR PRIDE; Q497K7; -.
DR Ensembl; ENSMUST00000042172; ENSMUSP00000039338; ENSMUSG00000037689.
DR GeneID; 78469; -.
DR KEGG; mmu:78469; -.
DR UCSC; uc008duk.2; mouse.
DR CTD; 388946; -.
DR MGI; MGI:1925719; Tmem247.
DR eggNOG; ENOG410J4VW; Eukaryota.
DR eggNOG; ENOG41113DE; LUCA.
DR GeneTree; ENSGT00390000002879; -.
DR HOGENOM; HOG000168313; -.
DR HOVERGEN; HBG108691; -.
DR InParanoid; Q497K7; -.
DR OMA; LFSKHYL; -.
DR OrthoDB; EOG091G0P0P; -.
DR PhylomeDB; Q497K7; -.
DR TreeFam; TF337834; -.
DR PRO; PR:Q497K7; -.
DR Proteomes; UP000000589; Chromosome 17.
DR Bgee; ENSMUSG00000037689; -.
DR ExpressionAtlas; Q497K7; baseline and differential.
DR Genevisible; Q497K7; MM.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029200; TMEM247.
DR Pfam; PF15444; TMEM247; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Complete proteome; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1 211 Transmembrane protein 247.
FT /FTId=PRO_0000328814.
FT TRANSMEM 159 179 Helical. {ECO:0000255}.
FT TRANSMEM 186 206 Helical. {ECO:0000255}.
FT COILED 119 148 {ECO:0000255}.
FT COMPBIAS 123 165 Gln-rich.
FT CONFLICT 178 179 II -> MM (in Ref. 1; BAB31481).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 1 211 ipfam:TMEM247 [T]
SQ SEQUENCE 211 AA; 23971 MW; 147D4E95953C8C13 CRC64;
MAMEDREVME ARGAGESCPT LSKVAPVDSM PEGKPKASLD AEVPKLELPT LEENGICEDR
DCPGPPRSLP PKSGPNAKGQ AGDGPGLESV ELPLPLETEH RNAMELEKVR MEFELTLLKY
LHQENERQRQ HEEVMEQLQQ QQQQQQALPH QFSGSLQDLL LPQNQFAMFF YCFIFIHIIY
VAKETVFFLF SKHYLFCLAA ILLCLIKTLW S
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