ID TM222_HUMAN Reviewed; 208 AA.
AC Q9H0R3; D3DPL6; Q53HD8; Q5FVE9;
DT 22-AUG-2006, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 2.
DT 15-MAR-2017, entry version 128.
DE RecName: Full=Transmembrane protein 222;
GN Name=TMEM222; Synonyms=C1orf160;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 18-208 (ISOFORM 1).
RC TISSUE=Lung carcinoma, and Spinal ganglion;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-208 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=11230166; DOI=10.1101/gr.GR1547R;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA Wambutt R., Korn B., Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and
RT analysis of 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-208 (ISOFORM 1).
RC TISSUE=Cerebellum;
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9H0R3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H0R3-2; Sequence=VSP_020090;
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB66618.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; FO393419; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471059; EAX07764.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX07766.1; -; Genomic_DNA.
DR EMBL; BC011579; AAH11579.2; -; mRNA.
DR EMBL; BC090039; AAH90039.1; -; mRNA.
DR EMBL; AL136683; CAB66618.1; ALT_INIT; mRNA.
DR EMBL; AK222642; BAD96362.1; -; mRNA.
DR CCDS; CCDS297.2; -. [Q9H0R3-1]
DR RefSeq; NP_115501.2; NM_032125.2. [Q9H0R3-1]
DR UniGene; Hs.469171; -.
DR ProteinModelPortal; Q9H0R3; -.
DR BioGrid; 123860; 10.
DR IntAct; Q9H0R3; 9.
DR MINT; MINT-1034622; -.
DR STRING; 9606.ENSP00000363189; -.
DR iPTMnet; Q9H0R3; -.
DR PhosphoSitePlus; Q9H0R3; -.
DR SwissPalm; Q9H0R3; -.
DR BioMuta; TMEM222; -.
DR DMDM; 112823989; -.
DR EPD; Q9H0R3; -.
DR MaxQB; Q9H0R3; -.
DR PaxDb; Q9H0R3; -.
DR PeptideAtlas; Q9H0R3; -.
DR PRIDE; Q9H0R3; -.
DR DNASU; 84065; -.
DR Ensembl; ENST00000374076; ENSP00000363189; ENSG00000186501. [Q9H0R3-1]
DR Ensembl; ENST00000611517; ENSP00000483276; ENSG00000186501. [Q9H0R3-1]
DR GeneID; 84065; -.
DR KEGG; hsa:84065; -.
DR UCSC; uc001bnr.5; human. [Q9H0R3-1]
DR CTD; 84065; -.
DR GeneCards; TMEM222; -.
DR HGNC; HGNC:25363; TMEM222.
DR HPA; HPA016579; -.
DR HPA; HPA059374; -.
DR neXtProt; NX_Q9H0R3; -.
DR PharmGKB; PA162406598; -.
DR eggNOG; KOG3150; Eukaryota.
DR eggNOG; ENOG4111G1S; LUCA.
DR GeneTree; ENSGT00390000007371; -.
DR HOGENOM; HOG000231333; -.
DR HOVERGEN; HBG055708; -.
DR InParanoid; Q9H0R3; -.
DR KO; K20726; -.
DR OrthoDB; EOG091G0RBA; -.
DR PhylomeDB; Q9H0R3; -.
DR TreeFam; TF105899; -.
DR ChiTaRS; TMEM222; human.
DR GeneWiki; Transmembrane_protein_222; -.
DR GenomeRNAi; 84065; -.
DR PRO; PR:Q9H0R3; -.
DR Proteomes; UP000005640; Chromosome 1.
DR Bgee; ENSG00000186501; -.
DR CleanEx; HS_TMEM222; -.
DR ExpressionAtlas; Q9H0R3; baseline and differential.
DR Genevisible; Q9H0R3; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR008496; DUF778.
DR PANTHER; PTHR20921; PTHR20921; 1.
DR Pfam; PF05608; DUF778; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1 208 Transmembrane protein 222.
FT /FTId=PRO_0000247963.
FT TOPO_DOM 1 55 Extracellular. {ECO:0000255}.
FT TRANSMEM 56 76 Helical. {ECO:0000255}.
FT TOPO_DOM 77 164 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 165 185 Helical. {ECO:0000255}.
FT TOPO_DOM 186 186 Extracellular. {ECO:0000255}.
FT TRANSMEM 187 207 Helical. {ECO:0000255}.
FT TOPO_DOM 208 208 Cytoplasmic. {ECO:0000255}.
FT VAR_SEQ 1 96 Missing (in isoform 2).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_020090.
FT CONFLICT 101 101 K -> E (in Ref. 5; BAD96362).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 119 178 ipfam:DUF778 [T]
FT MYHIT 61 111 ipfam:DUF778 [T]
SQ SEQUENCE 208 AA; 23230 MW; D1FB041F151D7BB7 CRC64;
MAEAEGSSLL LLPPPPPPPR MAEVEAPTAA ETDMKQYQGS GGVAMDVERS RFPYCVVWTP
IPVLTWFFPI IGHMGICTST GVIRDFAGPY FVSEDNMAFG KPAKYWKLDP AQVYASGPNA
WDTAVHDASE EYKHRMHNLC CDNCHSHVAL ALNLMRYNNS TNWNMVTLCF FCLLYGKYVS
VGAFVKTWLP FILLLGIILT VSLVFNLR
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