Entry euk:TM159_MOUSE

ID   TM159_MOUSE             Reviewed;         161 AA.
AC   Q922Z1; Q8C5E0;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   10-MAY-2017, entry version 90.
DE   RecName: Full=Promethin;
DE   AltName: Full=Transmembrane protein 159;
GN   Name=Tmem159;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, AND TISSUE SPECIFICITY.
RC   STRAIN=C57BL/6J; TISSUE=Liver;
RX   PubMed=15589683; DOI=10.1016/j.biochi.2004.09.015;
RA   Yu S., Viswakarma N., Batra S.K., Sambasiva Rao M., Reddy J.K.;
RT   "Identification of promethin and PGLP as two novel up-regulated genes
RT   in PPARgamma1-induced adipogenic mouse liver.";
RL   Biochimie 86:743-761(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Bone marrow, Heart, Inner ear, and Lung;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Prominently expressed in the heart and kidney.
CC       Expressed at higher levels in white fat as compared to brown fat
CC       and skeletal muscle. Expressed at lower levels in lung, liver and
CC       testis. {ECO:0000269|PubMed:15589683}.
CC   -!- INDUCTION: In liver with hepatic adiposis caused by PPAR gamma 1
CC       overexpression. {ECO:0000269|PubMed:15589683}.
CC   -!- SIMILARITY: Belongs to the TMEM159 family. {ECO:0000305}.
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DR   EMBL; AY167031; AAO11832.1; -; mRNA.
DR   EMBL; AK078811; BAC37405.1; -; mRNA.
DR   EMBL; AK087074; BAC39797.1; -; mRNA.
DR   EMBL; AK142240; BAE24990.1; -; mRNA.
DR   EMBL; AK150434; BAE29557.1; -; mRNA.
DR   EMBL; AK158048; BAE34335.1; -; mRNA.
DR   EMBL; AK158249; BAE34426.1; -; mRNA.
DR   EMBL; AK167135; BAE39281.1; -; mRNA.
DR   EMBL; AK167192; BAE39322.1; -; mRNA.
DR   EMBL; AK171378; BAE42420.1; -; mRNA.
DR   EMBL; BC006689; AAH06689.1; -; mRNA.
DR   CCDS; CCDS21791.1; -.
DR   RefSeq; NP_663561.1; NM_145586.1.
DR   RefSeq; XP_006507745.1; XM_006507682.3.
DR   UniGene; Mm.257952; -.
DR   STRING; 10090.ENSMUSP00000033210; -.
DR   PhosphoSitePlus; Q922Z1; -.
DR   MaxQB; Q922Z1; -.
DR   PaxDb; Q922Z1; -.
DR   PRIDE; Q922Z1; -.
DR   Ensembl; ENSMUST00000033210; ENSMUSP00000033210; ENSMUSG00000030917.
DR   Ensembl; ENSMUST00000118737; ENSMUSP00000114085; ENSMUSG00000030917.
DR   GeneID; 233806; -.
DR   KEGG; mmu:233806; -.
DR   UCSC; uc009jmh.1; mouse.
DR   CTD; 57146; -.
DR   MGI; MGI:1925752; Tmem159.
DR   eggNOG; ENOG410IZ20; Eukaryota.
DR   eggNOG; ENOG41126AQ; LUCA.
DR   GeneTree; ENSGT00390000006420; -.
DR   HOGENOM; HOG000069886; -.
DR   HOVERGEN; HBG094018; -.
DR   InParanoid; Q922Z1; -.
DR   OMA; WFSPRPL; -.
DR   OrthoDB; EOG091G0SFC; -.
DR   PhylomeDB; Q922Z1; -.
DR   TreeFam; TF335782; -.
DR   PRO; PR:Q922Z1; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   Bgee; ENSMUSG00000030917; -.
DR   CleanEx; MM_TMEM159; -.
DR   Genevisible; Q922Z1; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR029709; Promethin/TMEM159.
DR   PANTHER; PTHR14275:SF1; PTHR14275:SF1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Glycoprotein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    161       Promethin.
FT                                /FTId=PRO_0000279536.
FT   TRANSMEM     55     75       Helical. {ECO:0000255}.
FT   TRANSMEM     89    109       Helical. {ECO:0000255}.
FT   TRANSMEM    112    132       Helical. {ECO:0000255}.
FT   CARBOHYD     29     29       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CONFLICT    105    105       G -> S (in Ref. 2; BAC37405).
FT                                {ECO:0000305}.
SQ   SEQUENCE   161 AA;  17643 MW;  AB2527A56EEA6CF9 CRC64;
     MAKEEPPSVS RDLQELQRKL GLLLESFLNN SKVVAFMKSP VGRFLDRHPF VTLTVLMFVT
     MSAIPVGFFL LIVVLTSLGA LMGAILLEGL VISVCGLSLL CVLCGLGFLS LALSGIAMMS
     YVVVSCLMSY WFSPSRPLTQ QNANVDCQLA MKFTESERLI F
//