ID TM159_MOUSE Reviewed; 161 AA.
AC Q922Z1; Q8C5E0;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 10-MAY-2017, entry version 90.
DE RecName: Full=Promethin;
DE AltName: Full=Transmembrane protein 159;
GN Name=Tmem159;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J; TISSUE=Liver;
RX PubMed=15589683; DOI=10.1016/j.biochi.2004.09.015;
RA Yu S., Viswakarma N., Batra S.K., Sambasiva Rao M., Reddy J.K.;
RT "Identification of promethin and PGLP as two novel up-regulated genes
RT in PPARgamma1-induced adipogenic mouse liver.";
RL Biochimie 86:743-761(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, Heart, Inner ear, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Prominently expressed in the heart and kidney.
CC Expressed at higher levels in white fat as compared to brown fat
CC and skeletal muscle. Expressed at lower levels in lung, liver and
CC testis. {ECO:0000269|PubMed:15589683}.
CC -!- INDUCTION: In liver with hepatic adiposis caused by PPAR gamma 1
CC overexpression. {ECO:0000269|PubMed:15589683}.
CC -!- SIMILARITY: Belongs to the TMEM159 family. {ECO:0000305}.
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DR EMBL; AY167031; AAO11832.1; -; mRNA.
DR EMBL; AK078811; BAC37405.1; -; mRNA.
DR EMBL; AK087074; BAC39797.1; -; mRNA.
DR EMBL; AK142240; BAE24990.1; -; mRNA.
DR EMBL; AK150434; BAE29557.1; -; mRNA.
DR EMBL; AK158048; BAE34335.1; -; mRNA.
DR EMBL; AK158249; BAE34426.1; -; mRNA.
DR EMBL; AK167135; BAE39281.1; -; mRNA.
DR EMBL; AK167192; BAE39322.1; -; mRNA.
DR EMBL; AK171378; BAE42420.1; -; mRNA.
DR EMBL; BC006689; AAH06689.1; -; mRNA.
DR CCDS; CCDS21791.1; -.
DR RefSeq; NP_663561.1; NM_145586.1.
DR RefSeq; XP_006507745.1; XM_006507682.3.
DR UniGene; Mm.257952; -.
DR STRING; 10090.ENSMUSP00000033210; -.
DR PhosphoSitePlus; Q922Z1; -.
DR MaxQB; Q922Z1; -.
DR PaxDb; Q922Z1; -.
DR PRIDE; Q922Z1; -.
DR Ensembl; ENSMUST00000033210; ENSMUSP00000033210; ENSMUSG00000030917.
DR Ensembl; ENSMUST00000118737; ENSMUSP00000114085; ENSMUSG00000030917.
DR GeneID; 233806; -.
DR KEGG; mmu:233806; -.
DR UCSC; uc009jmh.1; mouse.
DR CTD; 57146; -.
DR MGI; MGI:1925752; Tmem159.
DR eggNOG; ENOG410IZ20; Eukaryota.
DR eggNOG; ENOG41126AQ; LUCA.
DR GeneTree; ENSGT00390000006420; -.
DR HOGENOM; HOG000069886; -.
DR HOVERGEN; HBG094018; -.
DR InParanoid; Q922Z1; -.
DR OMA; WFSPRPL; -.
DR OrthoDB; EOG091G0SFC; -.
DR PhylomeDB; Q922Z1; -.
DR TreeFam; TF335782; -.
DR PRO; PR:Q922Z1; -.
DR Proteomes; UP000000589; Chromosome 7.
DR Bgee; ENSMUSG00000030917; -.
DR CleanEx; MM_TMEM159; -.
DR Genevisible; Q922Z1; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029709; Promethin/TMEM159.
DR PANTHER; PTHR14275:SF1; PTHR14275:SF1; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1 161 Promethin.
FT /FTId=PRO_0000279536.
FT TRANSMEM 55 75 Helical. {ECO:0000255}.
FT TRANSMEM 89 109 Helical. {ECO:0000255}.
FT TRANSMEM 112 132 Helical. {ECO:0000255}.
FT CARBOHYD 29 29 N-linked (GlcNAc...) asparagine.
FT {ECO:0000255}.
FT CONFLICT 105 105 G -> S (in Ref. 2; BAC37405).
FT {ECO:0000305}.
SQ SEQUENCE 161 AA; 17643 MW; AB2527A56EEA6CF9 CRC64;
MAKEEPPSVS RDLQELQRKL GLLLESFLNN SKVVAFMKSP VGRFLDRHPF VTLTVLMFVT
MSAIPVGFFL LIVVLTSLGA LMGAILLEGL VISVCGLSLL CVLCGLGFLS LALSGIAMMS
YVVVSCLMSY WFSPSRPLTQ QNANVDCQLA MKFTESERLI F
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