ID TM156_HUMAN Reviewed; 296 AA.
AC Q8N614; Q9H5N9;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 10-MAY-2017, entry version 90.
DE RecName: Full=Transmembrane protein 156;
GN Name=TMEM156;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Smooth muscle;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PRO-105.
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK026888; BAB15583.1; -; mRNA.
DR EMBL; BC030803; AAH30803.1; -; mRNA.
DR CCDS; CCDS3448.1; -.
DR RefSeq; NP_001290157.1; NM_001303228.1.
DR RefSeq; NP_079219.1; NM_024943.2.
DR RefSeq; XP_011512051.1; XM_011513749.2.
DR UniGene; Hs.374147; -.
DR ProteinModelPortal; Q8N614; -.
DR STRING; 9606.ENSP00000371364; -.
DR iPTMnet; Q8N614; -.
DR PhosphoSitePlus; Q8N614; -.
DR BioMuta; TMEM156; -.
DR DMDM; 145566966; -.
DR PaxDb; Q8N614; -.
DR PeptideAtlas; Q8N614; -.
DR PRIDE; Q8N614; -.
DR Ensembl; ENST00000381938; ENSP00000371364; ENSG00000121895.
DR GeneID; 80008; -.
DR KEGG; hsa:80008; -.
DR UCSC; uc003gto.4; human.
DR CTD; 80008; -.
DR GeneCards; TMEM156; -.
DR HGNC; HGNC:26260; TMEM156.
DR neXtProt; NX_Q8N614; -.
DR OpenTargets; ENSG00000121895; -.
DR PharmGKB; PA145007464; -.
DR eggNOG; ENOG410IPSV; Eukaryota.
DR eggNOG; ENOG41116BG; LUCA.
DR GeneTree; ENSGT00390000017929; -.
DR HOGENOM; HOG000154613; -.
DR HOVERGEN; HBG098801; -.
DR InParanoid; Q8N614; -.
DR OMA; CIHISLH; -.
DR OrthoDB; EOG091G0BTY; -.
DR PhylomeDB; Q8N614; -.
DR TreeFam; TF336964; -.
DR GenomeRNAi; 80008; -.
DR PRO; PR:Q8N614; -.
DR Proteomes; UP000005640; Chromosome 4.
DR Bgee; ENSG00000121895; -.
DR CleanEx; HS_TMEM156; -.
DR ExpressionAtlas; Q8N614; baseline and differential.
DR Genevisible; Q8N614; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029374; TMEM156.
DR PANTHER; PTHR14788; PTHR14788; 1.
DR Pfam; PF15106; TMEM156; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Glycoprotein; Membrane; Polymorphism;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1 296 Transmembrane protein 156.
FT /FTId=PRO_0000284505.
FT TOPO_DOM 1 4 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 5 25 Helical. {ECO:0000255}.
FT TOPO_DOM 26 211 Extracellular. {ECO:0000255}.
FT TRANSMEM 212 232 Helical. {ECO:0000255}.
FT TOPO_DOM 233 296 Cytoplasmic. {ECO:0000255}.
FT CARBOHYD 45 45 N-linked (GlcNAc...) asparagine.
FT {ECO:0000255}.
FT CARBOHYD 156 156 N-linked (GlcNAc...) asparagine.
FT {ECO:0000255}.
FT VARIANT 48 48 Y -> C (in dbSNP:rs35576563).
FT /FTId=VAR_031756.
FT VARIANT 105 105 S -> P (in dbSNP:rs11542133).
FT {ECO:0000269|PubMed:15489334}.
FT /FTId=VAR_051430.
FT VARIANT 212 212 M -> T (in dbSNP:rs2276887).
FT /FTId=VAR_031757.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 39 264 ipfam:TMEM156 [T]
SQ SEQUENCE 296 AA; 34323 MW; 54DE078ECC1BCE97 CRC64;
MTKTALLKLF VAIVITFILI LPEYFKTPKE RTLELSCLEV CLQSNFTYSL SSLNFSFVTF
LQPVRETQII MRIFLNPSNF RNFTRTCQDI TGEFKMCSSC LVCESKGNMD FISQEQTSKV
LIRRGSMEVK ANDFHSPCQH FNFSVAPLVD HLEEYNTTCH LKNHTGRSTI MEDEPSKEKS
INYTCRIMEY PNDCIHISLH LEMDIKNITC SMKITWYILV LLVFIFLIIL TIRKILEGQR
RVQKWQSHRD KPTSVLLRGS DSEKLRALNV QVLSAETTQR LPLDQVQEVL PPIPEL
//
|
