Entry euk:TM139_HUMAN

ID   TM139_HUMAN             Reviewed;         216 AA.
AC   Q8IV31; B2RCL5; D3DXD4; Q6ZME2; Q8NC22; Q96AU8;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   15-MAR-2017, entry version 99.
DE   RecName: Full=Transmembrane protein 139;
DE   Flags: Precursor;
GN   Name=TMEM139; ORFNames=UNQ1932/PRO4407;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Hepatoma, and Small intestine;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA   Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA   Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA   Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA   Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA   Isogai T.;
RT   "Signal sequence and keyword trap in silico for selection of full-
RT   length human cDNAs encoding secretion or membrane proteins from oligo-
RT   capped cDNA libraries.";
RL   DNA Res. 12:117-126(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12690205; DOI=10.1126/science.1083423;
RA   Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA   Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA   Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA   Kanematsu E., Gentles S., Christopoulos C.C., Choufani S.,
RA   Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z.,
RA   Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C.,
RA   Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J.,
RA   Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F.,
RA   Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F.,
RA   Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H.,
RA   Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G.,
RA   Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P.,
RA   Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J.,
RA   Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F.,
RA   Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B.,
RA   Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA   Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W.,
RA   Mural R.J., Adams M.D., Tsui L.-C.;
RT   "Human chromosome 7: DNA sequence and biology.";
RL   Science 300:767-772(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Bone marrow, and Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [8]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-155, AND IDENTIFICATION
RP   BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA   Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA   Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA   Mann M.;
RT   "Quantitative phosphoproteomics reveals widespread full
RT   phosphorylation site occupancy during mitosis.";
RL   Sci. Signal. 3:RA3-RA3(2010).
RN   [9]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146, AND IDENTIFICATION
RP   BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [10]
RP   FUNCTION, AND INTERACTION WITH SLC4A1.
RX   PubMed=26049106; DOI=10.1016/j.bbrc.2015.05.128;
RA   Nuiplot N.O., Junking M., Duangtum N., Khunchai S., Sawasdee N.,
RA   Yenchitsomanus P.T., Akkarapatumwong V.;
RT   "Transmembrane protein 139 (TMEM139) interacts with human kidney
RT   isoform of anion exchanger 1 (kAE1).";
RL   Biochem. Biophys. Res. Commun. 463:706-711(2015).
CC   -!- FUNCTION: May be involved in cellular trafficking of proteins such
CC       as SLC4A1. {ECO:0000305|PubMed:26049106}.
CC   -!- SUBUNIT: Interacts with isoform 2 of SLC4A1 (PubMed:26049106).
CC       {ECO:0000269|PubMed:26049106}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH16719.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
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DR   EMBL; AY358781; AAQ89141.1; -; mRNA.
DR   EMBL; AK172816; BAD18786.1; -; mRNA.
DR   EMBL; AK075067; BAC11382.1; -; mRNA.
DR   EMBL; AK315170; BAG37612.1; -; mRNA.
DR   EMBL; CH236959; EAL23784.1; -; Genomic_DNA.
DR   EMBL; CH471198; EAW51871.1; -; Genomic_DNA.
DR   EMBL; CH471198; EAW51873.1; -; Genomic_DNA.
DR   EMBL; CH471198; EAW51875.1; -; Genomic_DNA.
DR   EMBL; BC016719; AAH16719.1; ALT_INIT; mRNA.
DR   EMBL; BC035517; AAH35517.1; -; mRNA.
DR   CCDS; CCDS5878.1; -.
DR   RefSeq; NP_001229702.1; NM_001242773.2.
DR   RefSeq; NP_001229703.1; NM_001242774.2.
DR   RefSeq; NP_001229704.1; NM_001242775.2.
DR   RefSeq; NP_001269805.1; NM_001282876.1.
DR   RefSeq; NP_001269806.1; NM_001282877.1.
DR   RefSeq; NP_699176.1; NM_153345.3.
DR   UniGene; Hs.17558; -.
DR   UniGene; Hs.731832; -.
DR   ProteinModelPortal; Q8IV31; -.
DR   BioGrid; 126439; 3.
DR   IntAct; Q8IV31; 1.
DR   MINT; MINT-1193541; -.
DR   STRING; 9606.ENSP00000352284; -.
DR   TCDB; 8.A.60.1.1; the transmembrane protein 139 (tmem139) family.
DR   iPTMnet; Q8IV31; -.
DR   PhosphoSitePlus; Q8IV31; -.
DR   BioMuta; TMEM139; -.
DR   DMDM; 74728027; -.
DR   PaxDb; Q8IV31; -.
DR   PeptideAtlas; Q8IV31; -.
DR   PRIDE; Q8IV31; -.
DR   Ensembl; ENST00000359333; ENSP00000352284; ENSG00000178826.
DR   Ensembl; ENST00000409102; ENSP00000386879; ENSG00000178826.
DR   Ensembl; ENST00000409244; ENSP00000386335; ENSG00000178826.
DR   Ensembl; ENST00000409541; ENSP00000387044; ENSG00000178826.
DR   Ensembl; ENST00000410004; ENSP00000386564; ENSG00000178826.
DR   GeneID; 135932; -.
DR   KEGG; hsa:135932; -.
DR   UCSC; uc003wck.6; human.
DR   CTD; 135932; -.
DR   DisGeNET; 135932; -.
DR   GeneCards; TMEM139; -.
DR   HGNC; HGNC:22058; TMEM139.
DR   HPA; HPA036982; -.
DR   HPA; HPA036983; -.
DR   MIM; 616524; gene.
DR   neXtProt; NX_Q8IV31; -.
DR   OpenTargets; ENSG00000178826; -.
DR   PharmGKB; PA144596260; -.
DR   eggNOG; ENOG410IW7A; Eukaryota.
DR   eggNOG; ENOG41116AZ; LUCA.
DR   GeneTree; ENSGT00390000002723; -.
DR   HOGENOM; HOG000059642; -.
DR   HOVERGEN; HBG070074; -.
DR   InParanoid; Q8IV31; -.
DR   OMA; ESQCRPQ; -.
DR   OrthoDB; EOG091G0UMO; -.
DR   PhylomeDB; Q8IV31; -.
DR   TreeFam; TF338466; -.
DR   GenomeRNAi; 135932; -.
DR   PRO; PR:Q8IV31; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000178826; -.
DR   CleanEx; HS_TMEM139; -.
DR   Genevisible; Q8IV31; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Complete proteome; Membrane; Phosphoprotein; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     25       {ECO:0000255}.
FT   CHAIN        26    216       Transmembrane protein 139.
FT                                /FTId=PRO_0000285948.
FT   TOPO_DOM     26     34       Extracellular. {ECO:0000255}.
FT   TRANSMEM     35     55       Helical. {ECO:0000255}.
FT   TOPO_DOM     56    216       Cytoplasmic. {ECO:0000255}.
FT   MOD_RES     146    146       Phosphoserine.
FT                                {ECO:0000244|PubMed:23186163}.
FT   MOD_RES     155    155       Phosphoserine.
FT                                {ECO:0000244|PubMed:20068231}.
FT   CONFLICT    203    203       D -> G (in Ref. 2; BAD18786).
FT                                {ECO:0000305}.
FT   CONFLICT    209    209       Y -> C (in Ref. 3; BAC11382).
FT                                {ECO:0000305}.
SQ   SEQUENCE   216 AA;  23729 MW;  DF5A7DB1E4126063 CRC64;
     MVPMHLLGRL EKPLLLLCCA SFLLGLALLG IKTDITPVAY FFLTLGGFFL FAYLLVRFLE
     WGLRSQLQSM QTESPGPSGN ARDNEAFEVP VYEEAVVGLE SQCRPQELDQ PPPYSTVVIP
     PAPEEEQPSH PEGSRRAKLE QRRMASEGSM AQEGSPGRAP INLRLRGPRA VSTAPDLQSL
     AAVPTLEPLT PPPAYDVCFG HPDDDSVFYE DNWAPP
//