ID TM134_MOUSE Reviewed; 195 AA.
AC Q8R0J4; Q3TLG9; Q8C1M3; Q9CR66;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 10-MAY-2017, entry version 82.
DE RecName: Full=Transmembrane protein 134;
GN Name=Tmem134;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=C57BL/6J;
RC TISSUE=Embryonic stem cell, Kidney, Mammary gland, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-93, AND IDENTIFICATION
RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Liver, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and
RT expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8R0J4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8R0J4-2; Sequence=VSP_023456;
CC Name=3;
CC IsoId=Q8R0J4-3; Sequence=VSP_023455;
CC Note=No experimental confirmation available.;
CC -!- SIMILARITY: Belongs to the TMEM134/TMEM230 family. {ECO:0000305}.
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DR EMBL; AK002220; BAB21944.1; -; mRNA.
DR EMBL; AK009745; BAB26475.1; -; mRNA.
DR EMBL; AK010323; BAC25290.1; -; mRNA.
DR EMBL; AK166519; BAE38823.1; -; mRNA.
DR EMBL; BC026765; AAH26765.1; -; mRNA.
DR RefSeq; NP_001072117.1; NM_001078649.1. [Q8R0J4-1]
DR RefSeq; NP_080165.1; NM_025889.2. [Q8R0J4-2]
DR UniGene; Mm.276255; -.
DR SMR; Q8R0J4; -.
DR iPTMnet; Q8R0J4; -.
DR PhosphoSitePlus; Q8R0J4; -.
DR SwissPalm; Q8R0J4; -.
DR PeptideAtlas; Q8R0J4; -.
DR PRIDE; Q8R0J4; -.
DR GeneID; 66990; -.
DR KEGG; mmu:66990; -.
DR UCSC; uc008fyr.1; mouse. [Q8R0J4-1]
DR UCSC; uc008fys.1; mouse. [Q8R0J4-2]
DR CTD; 80194; -.
DR MGI; MGI:1914240; Tmem134.
DR HOGENOM; HOG000145514; -.
DR HOVERGEN; HBG093689; -.
DR InParanoid; Q8R0J4; -.
DR PhylomeDB; Q8R0J4; -.
DR PRO; PR:Q8R0J4; -.
DR Proteomes; UP000000589; Unplaced.
DR Bgee; ENSMUSG00000097394; -.
DR CleanEx; MM_TMEM134; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR008590; DUF872_TM.
DR Pfam; PF05915; DUF872; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1 195 Transmembrane protein 134.
FT /FTId=PRO_0000279486.
FT TOPO_DOM 1 122 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 123 143 Helical. {ECO:0000255}.
FT TOPO_DOM 144 154 Extracellular. {ECO:0000255}.
FT TRANSMEM 155 175 Helical. {ECO:0000255}.
FT TOPO_DOM 176 195 Cytoplasmic. {ECO:0000255}.
FT MOD_RES 93 93 Phosphoserine.
FT {ECO:0000244|PubMed:21183079}.
FT VAR_SEQ 80 88 Missing (in isoform 3).
FT {ECO:0000303|PubMed:16141072}.
FT /FTId=VSP_023455.
FT VAR_SEQ 136 150 Missing (in isoform 2).
FT {ECO:0000303|PubMed:16141072}.
FT /FTId=VSP_023456.
FT CONFLICT 66 66 G -> R (in Ref. 1; BAE38823).
FT {ECO:0000305}.
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CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 57 193 ipfam:DUF872 [T]
SQ SEQUENCE 195 AA; 21637 MW; D34CCCC924937662 CRC64;
MSAARPQFSI DDAFELTLED AGPEPESSGV ARFGPLHFER RARFEVADED KQSRLRYQNL
ENDEDGAQAS PEPDGGVSTR DSGHMSVRSS QWSFSTISSS TQRSYNACCS WTQHPLIQKN
RRVVLASFLL LLLGLVLILV GVGLEVAPSP GVSSAIFFVP GILLLVPGVY HVIFIYCAVK
GRRGFQFFYL PYFEK
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