ID T176A_MOUSE Reviewed; 244 AA.
AC Q9DCS1; Q3UCE2; Q8BV92; Q8K4T0;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 2.
DT 10-MAY-2017, entry version 102.
DE RecName: Full=Transmembrane protein 176A;
DE AltName: Full=Gene signature 188;
DE AltName: Full=Kidney-expressed gene 2 protein;
GN Name=Tmem176a; Synonyms=Gs188, Keg2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6N; TISSUE=Kidney;
RX PubMed=11967007; DOI=10.1046/j.1523-1755.2002.00300.x;
RA Nakajima H., Takenaka M., Kaimori J.-Y., Nagasawa Y., Kosugi A.,
RA Kawamoto S., Imai E., Hori M., Okubo K.;
RT "Gene expression profile of renal proximal tubules regulated by
RT proteinuria.";
RL Kidney Int. 61:1577-1587(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C3H/HeJ, and C57BL/6J;
RC TISSUE=Bone marrow, Brain, Cerebellum, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E.,
RA Mollenhauer J., Wiemann S., Schick M., Korn B.;
RT "Cloning of mouse full open reading frames in Gateway(R) system entry
RT vector (pDONR201).";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, AND IDENTIFICATION
RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and
RT expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in lung, kidney and
CC spleen. {ECO:0000269|PubMed:11967007}.
CC -!- INDUCTION: Up-regulated in kidney upon proteinuria.
CC {ECO:0000269|PubMed:11967007}.
CC -!- SIMILARITY: Belongs to the TMEM176 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE29671.1; Type=Frameshift; Positions=228; Evidence={ECO:0000305};
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DR EMBL; AB063313; BAB97230.1; -; mRNA.
DR EMBL; AK002546; BAB22177.2; -; mRNA.
DR EMBL; AK079378; BAC37625.1; -; mRNA.
DR EMBL; AK150576; BAE29671.1; ALT_FRAME; mRNA.
DR EMBL; AK165660; BAE38322.1; -; mRNA.
DR EMBL; CT010190; CAJ18398.1; -; mRNA.
DR EMBL; BC010831; AAH10831.2; -; mRNA.
DR CCDS; CCDS39482.1; -.
DR RefSeq; NP_001091741.1; NM_001098271.1.
DR RefSeq; NP_079602.4; NM_025326.4.
DR UniGene; Mm.27061; -.
DR STRING; 10090.ENSMUSP00000098969; -.
DR iPTMnet; Q9DCS1; -.
DR PhosphoSitePlus; Q9DCS1; -.
DR MaxQB; Q9DCS1; -.
DR PaxDb; Q9DCS1; -.
DR PeptideAtlas; Q9DCS1; -.
DR PRIDE; Q9DCS1; -.
DR Ensembl; ENSMUST00000101426; ENSMUSP00000098969; ENSMUSG00000023367.
DR Ensembl; ENSMUST00000168406; ENSMUSP00000131775; ENSMUSG00000023367.
DR Ensembl; ENSMUST00000204482; ENSMUSP00000145101; ENSMUSG00000023367.
DR GeneID; 66058; -.
DR KEGG; mmu:66058; -.
DR UCSC; uc009bvw.1; mouse.
DR CTD; 55365; -.
DR MGI; MGI:1913308; Tmem176a.
DR eggNOG; ENOG410IX21; Eukaryota.
DR eggNOG; ENOG410Z9YG; LUCA.
DR GeneTree; ENSGT00530000064074; -.
DR HOGENOM; HOG000290691; -.
DR HOVERGEN; HBG094019; -.
DR InParanoid; Q9DCS1; -.
DR OMA; SWVMQIV; -.
DR OrthoDB; EOG091G0VIE; -.
DR PhylomeDB; Q9DCS1; -.
DR TreeFam; TF335389; -.
DR ChiTaRS; Tmem176a; mouse.
DR PRO; PR:Q9DCS1; -.
DR Proteomes; UP000000589; Chromosome 6.
DR Bgee; ENSMUSG00000023367; -.
DR CleanEx; MM_TMEM176A; -.
DR ExpressionAtlas; Q9DCS1; baseline and differential.
DR Genevisible; Q9DCS1; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:2001199; P:negative regulation of dendritic cell differentiation; IMP:MGI.
DR InterPro; IPR007237; CD20-like.
DR InterPro; IPR009281; TMEM176A/TMEM176B.
DR PANTHER; PTHR15756; PTHR15756; 1.
DR Pfam; PF04103; CD20; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1 244 Transmembrane protein 176A.
FT /FTId=PRO_0000279873.
FT TRANSMEM 60 80 Helical. {ECO:0000255}.
FT TRANSMEM 92 112 Helical. {ECO:0000255}.
FT TRANSMEM 122 142 Helical. {ECO:0000255}.
FT TRANSMEM 204 224 Helical. {ECO:0000255}.
FT MOD_RES 42 42 Phosphoserine.
FT {ECO:0000244|PubMed:21183079}.
FT CONFLICT 218 218 P -> H (in Ref. 2; BAC37625).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 64 222 ipfam:CD20 [T]
SQ SEQUENCE 244 AA; 26596 MW; 515A3988A6243CCA CRC64;
MSTDMETAVV GKVDPEAPQP THIDVHIHQE SALAKLLLAG CSLLRIPASA STQSQGSSRV
LVASWVVQTV LGALSVVLGG TLYIGHYLAM YSEGAPFWTG IVAMLAGAVA FLHKKRGGTC
WALMRTLLVL ASFCTAVAAI VIGSRELNFY WYFLGDDVCQ RDSSYGWSTM PRTTPVPEEA
DRIALCIYYT SMLKTLLMSL QAMLLGIWVL LLLASLTPVC VYIWKRFFTK AETEEKKLLG
AAVI
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