ID STK31_HUMAN Reviewed; 1019 AA.
AC Q9BXU1; B4DZ06; B7WPP5; C9J4F9; Q6PCD3; Q9BXH8;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 2.
DT 10-MAY-2017, entry version 150.
DE RecName: Full=Serine/threonine-protein kinase 31;
DE EC=2.7.11.1;
DE AltName: Full=Serine/threonine-protein kinase NYD-SPK;
DE AltName: Full=Sugen kinase 396;
DE Short=SgK396;
GN Name=STK31; Synonyms=SGK396;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=11279525; DOI=10.1038/86927;
RA Wang P.J., McCarrey J.R., Yang F., Page D.C.;
RT "An abundance of X-linked genes expressed in spermatogonia.";
RL Nat. Genet. 27:422-426(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RA Zhou Z.M.;
RT "Cloning of a new protein kinase gene related to human testis
RT development.";
RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA Waterston R.H., Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
RP HIS-71.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP VARIANTS [LARGE SCALE ANALYSIS] HIS-71; PHE-125; LYS-261; ASN-268;
RP LYS-277; THR-393; GLU-410; PRO-489; THR-600; LYS-621; ILE-623;
RP ARG-684; TYR-684; LYS-709; LEU-860; MET-1000 AND SER-1010.
RX PubMed=17344846; DOI=10.1038/nature05610;
RA Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C.,
RA Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S.,
RA O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S.,
RA Bhamra G., Buck G., Choudhury B., Clements J., Cole J., Dicks E.,
RA Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J.,
RA Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K.,
RA Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T.,
RA West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P.,
RA Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E.,
RA DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E.,
RA Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T.,
RA Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.;
RT "Patterns of somatic mutation in human cancer genomes.";
RL Nature 446:153-158(2007).
CC -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9BXU1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BXU1-2; Sequence=VSP_024389;
CC Note=No experimental confirmation available.;
CC Name=3;
CC IsoId=Q9BXU1-3; Sequence=VSP_045210;
CC -!- TISSUE SPECIFICITY: Testis specific.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr
CC protein kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
CC -!- CAUTION: Ser-854 is present instead of the conserved Asp which is
CC expected to be an active site residue. {ECO:0000305}.
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DR EMBL; AF285599; AAK31978.1; -; mRNA.
DR EMBL; AF332194; AAK17193.1; -; mRNA.
DR EMBL; AK302689; BAG63918.1; -; mRNA.
DR EMBL; AC003087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC008176; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC059374; AAH59374.1; -; mRNA.
DR CCDS; CCDS43556.1; -. [Q9BXU1-2]
DR CCDS; CCDS5386.1; -. [Q9BXU1-1]
DR CCDS; CCDS59049.1; -. [Q9BXU1-3]
DR RefSeq; NP_001247433.1; NM_001260504.1. [Q9BXU1-2]
DR RefSeq; NP_001247434.1; NM_001260505.1. [Q9BXU1-3]
DR RefSeq; NP_113602.2; NM_031414.4. [Q9BXU1-1]
DR RefSeq; NP_116562.2; NM_032944.3. [Q9BXU1-2]
DR UniGene; Hs.309767; -.
DR ProteinModelPortal; Q9BXU1; -.
DR BioGrid; 121097; 4.
DR IntAct; Q9BXU1; 1.
DR STRING; 9606.ENSP00000348132; -.
DR BindingDB; Q9BXU1; -.
DR ChEMBL; CHEMBL6151; -.
DR GuidetoPHARMACOLOGY; 2220; -.
DR iPTMnet; Q9BXU1; -.
DR PhosphoSitePlus; Q9BXU1; -.
DR BioMuta; STK31; -.
DR DMDM; 143811463; -.
DR MaxQB; Q9BXU1; -.
DR PaxDb; Q9BXU1; -.
DR PeptideAtlas; Q9BXU1; -.
DR PRIDE; Q9BXU1; -.
DR DNASU; 56164; -.
DR Ensembl; ENST00000354639; ENSP00000346660; ENSG00000196335. [Q9BXU1-2]
DR Ensembl; ENST00000355870; ENSP00000348132; ENSG00000196335. [Q9BXU1-1]
DR Ensembl; ENST00000433467; ENSP00000411852; ENSG00000196335. [Q9BXU1-3]
DR GeneID; 56164; -.
DR KEGG; hsa:56164; -.
DR UCSC; uc003sws.6; human. [Q9BXU1-1]
DR CTD; 56164; -.
DR DisGeNET; 56164; -.
DR GeneCards; STK31; -.
DR H-InvDB; HIX0006524; -.
DR HGNC; HGNC:11407; STK31.
DR HPA; HPA023194; -.
DR MIM; 605790; gene.
DR neXtProt; NX_Q9BXU1; -.
DR OpenTargets; ENSG00000196335; -.
DR PharmGKB; PA36214; -.
DR eggNOG; ENOG410IF5N; Eukaryota.
DR eggNOG; ENOG410XQIZ; LUCA.
DR GeneTree; ENSGT00390000007287; -.
DR HOGENOM; HOG000154440; -.
DR HOVERGEN; HBG062739; -.
DR InParanoid; Q9BXU1; -.
DR KO; K16316; -.
DR OMA; NRNKDIM; -.
DR OrthoDB; EOG091G0PO7; -.
DR PhylomeDB; Q9BXU1; -.
DR TreeFam; TF105335; -.
DR BRENDA; 2.7.11.1; 2681.
DR SignaLink; Q9BXU1; -.
DR GenomeRNAi; 56164; -.
DR PRO; PR:Q9BXU1; -.
DR Proteomes; UP000005640; Chromosome 7.
DR Bgee; ENSG00000196335; -.
DR CleanEx; HS_STK31; -.
DR ExpressionAtlas; Q9BXU1; baseline and differential.
DR Genevisible; Q9BXU1; HS.
DR GO; GO:0001669; C:acrosomal vesicle; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IBA:GO_Central.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006401; P:RNA catabolic process; IBA:GO_Central.
DR InterPro; IPR011009; Kinase-like_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR016071; Staphylococal_nuclease_OB-fold.
DR InterPro; IPR002999; Tudor.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00567; TUDOR; 1.
DR SMART; SM00220; S_TKc; 1.
DR SMART; SM00333; TUDOR; 1.
DR SUPFAM; SSF50199; SSF50199; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50304; TUDOR; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Coiled coil; Complete proteome;
KW Kinase; Nucleotide-binding; Polymorphism; Reference proteome;
KW Serine/threonine-protein kinase; Transferase.
FT CHAIN 1 1019 Serine/threonine-protein kinase 31.
FT /FTId=PRO_0000086715.
FT DOMAIN 78 137 Tudor. {ECO:0000255|PROSITE-
FT ProRule:PRU00211}.
FT DOMAIN 710 1019 Protein kinase. {ECO:0000255|PROSITE-
FT ProRule:PRU00159}.
FT NP_BIND 716 724 ATP. {ECO:0000255|PROSITE-
FT ProRule:PRU00159}.
FT COILED 298 355 {ECO:0000255}.
FT BINDING 737 737 ATP. {ECO:0000255|PROSITE-
FT ProRule:PRU00159}.
FT VAR_SEQ 1 23 Missing (in isoform 2).
FT {ECO:0000303|Ref.2}.
FT /FTId=VSP_024389.
FT VAR_SEQ 921 943 Missing (in isoform 3).
FT {ECO:0000303|PubMed:14702039}.
FT /FTId=VSP_045210.
FT VARIANT 71 71 Q -> H (in dbSNP:rs6945306).
FT {ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:17344846}.
FT /FTId=VAR_031600.
FT VARIANT 125 125 S -> F (in dbSNP:rs56268851).
FT {ECO:0000269|PubMed:17344846}.
FT /FTId=VAR_041150.
FT VARIANT 261 261 E -> K (in dbSNP:rs10264952).
FT {ECO:0000269|PubMed:17344846}.
FT /FTId=VAR_031601.
FT VARIANT 268 268 K -> N (in dbSNP:rs10264967).
FT {ECO:0000269|PubMed:17344846}.
FT /FTId=VAR_031602.
FT VARIANT 277 277 I -> K (in dbSNP:rs55950645).
FT {ECO:0000269|PubMed:17344846}.
FT /FTId=VAR_041151.
FT VARIANT 362 362 T -> P (in dbSNP:rs35545265).
FT /FTId=VAR_031603.
FT VARIANT 385 385 R -> C (in dbSNP:rs35995607).
FT /FTId=VAR_051675.
FT VARIANT 393 393 A -> T (in dbSNP:rs56244148).
FT {ECO:0000269|PubMed:17344846}.
FT /FTId=VAR_041152.
FT VARIANT 410 410 G -> E (in dbSNP:rs4722266).
FT {ECO:0000269|PubMed:17344846}.
FT /FTId=VAR_031604.
FT VARIANT 489 489 A -> P (in dbSNP:rs34414354).
FT {ECO:0000269|PubMed:17344846}.
FT /FTId=VAR_041153.
FT VARIANT 600 600 A -> T (in dbSNP:rs55796076).
FT {ECO:0000269|PubMed:17344846}.
FT /FTId=VAR_041154.
FT VARIANT 621 621 N -> K (in dbSNP:rs10263079).
FT {ECO:0000269|PubMed:17344846}.
FT /FTId=VAR_041155.
FT VARIANT 623 623 S -> I (in dbSNP:rs10247878).
FT {ECO:0000269|PubMed:17344846}.
FT /FTId=VAR_041156.
FT VARIANT 684 684 H -> R (in dbSNP:rs41273999).
FT {ECO:0000269|PubMed:17344846}.
FT /FTId=VAR_041157.
FT VARIANT 684 684 H -> Y (in a lung neuroendocrine
FT carcinoma sample; somatic mutation).
FT {ECO:0000269|PubMed:17344846}.
FT /FTId=VAR_041158.
FT VARIANT 709 709 E -> K (in dbSNP:rs56181834).
FT {ECO:0000269|PubMed:17344846}.
FT /FTId=VAR_041159.
FT VARIANT 860 860 V -> L (in a lung small cell carcinoma
FT sample; somatic mutation).
FT {ECO:0000269|PubMed:17344846}.
FT /FTId=VAR_041160.
FT VARIANT 1000 1000 T -> M (in dbSNP:rs55794023).
FT {ECO:0000269|PubMed:17344846}.
FT /FTId=VAR_041161.
FT VARIANT 1009 1009 K -> T (in dbSNP:rs33998018).
FT /FTId=VAR_031605.
FT VARIANT 1010 1010 T -> S (in dbSNP:rs56391043).
FT {ECO:0000269|PubMed:17344846}.
FT /FTId=VAR_041162.
FT CONFLICT 300 300 I -> F (in Ref. 2; AAK17193).
FT {ECO:0000305}.
FT CONFLICT 509 509 F -> Y (in Ref. 2; AAK17193).
FT {ECO:0000305}.
FT CONFLICT 621 623 NKS -> KKI (in Ref. 1; AAK31978).
FT {ECO:0000305}.
FT CONFLICT 715 715 Y -> C (in Ref. 2; AAK17193).
FT {ECO:0000305}.
FT CONFLICT 820 820 V -> A (in Ref. 2; AAK17193).
FT {ECO:0000305}.
FT CONFLICT 948 948 K -> I (in Ref. 2; AAK17193).
FT {ECO:0000305}.
FT CONFLICT 963 963 A -> G (in Ref. 2; AAK17193).
FT {ECO:0000305}.
FT CONFLICT 1000 1000 T -> P (in Ref. 2; AAK17193).
FT {ECO:0000305}.
FT CONFLICT 1010 1010 T -> P (in Ref. 1; AAK31978).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 77 135 ismart:TUDOR [T]
FT MYHIT 740 972 ismart:S_TKc [T]
FT MYHIT 29 147 ipfam:TUDOR [T]
FT MYHIT 799 940 ipfam:Pkinase [T]
FT MYHIT 78 137 iprf:TUDOR [T]
FT MYHIT 710 1019 iprf:PROTEIN_KINASE_DOM [T]
SQ SEQUENCE 1019 AA; 115694 MW; C2EFF005A820E102 CRC64;
MWVQGHSSRA SATESVSFSG IVQMDEDTHY DKVEDVVGSH IEDAVTFWAQ SINRNKDIMK
IGCSLSEVCP QASSVLGNLD PNKIYGGLFS EDQCWYRCKV LKIISVEKCL VRYIDYGNTE
ILNRSDIVEI PLELQFSSVA KKYKLWGLHI PSDQEVTQFD QGTTFLGSLI FEKEIKMRIK
ATSEDGTVIA QAEYGSVDIG EEVLKKGFAE KCRLASRTDI CEEKKLDPGQ LVLRNLKSPI
PLWGHRSNQS TFSRPKGHLS EKMTLDLKDE NDAGNLITFP KESLAVGDFN LGSNVSLEKI
KQDQKLIEEN EKLKTEKDAL LESYKALELK VEQIAQELQQ EKAAAVDLTN HLEYTLKTYI
DTRMKNLAAK MEILKEMRHV DISVRFGKDL SDAIQVLDEG CFTTPASLNG LEIIWAEYSL
AQENIKTCEY VSEGNILIAQ RNEMQQKLYM SVEDFILEVD ESSLNKRLKT LQDLSVSLEA
VYGQAKEGAN SDEILKKFYD WKCDKREEFT SVRSETDASL HRLVAWFQRT LKVFDLSVEG
SLISEDAMDN IDEILEKTES SVCKELEIAL VDQGDADKEI ISNTYSQVLQ KIHSEERLIA
TVQAKYKDSI EFKKQLIEYL NKSPSVDHLL SIKKTLKSLK ALLRWKLVEK SNLEESDDPD
GSQIEKIKEE ITQLRNNVFQ EIYHEREEYE MLTSLAQKWF PELPLLHPEI GLLKYMNSGG
LLTMSLERDL LDAEPMKELS SKRPLVRSEV NGQIILLKGY SVDVDTEAKV IERAATYHRA
WREAEGDSGL LPLIFLFLCK SDPMAYLMVP YYPRANLNAV QANMPLNSEE TLKVMKGVAQ
GLHTLHKADI IHGSLHQNNV FALNREQGIV GDFDFTKSVS QRASVNMMVG DLSLMSPELK
MGKPASPGSD LYAYGCLLLW LSVQNQEFEI NKDGIPKVDQ FHLDDKVKSL LCSLICYRSS
MTAEQVLNAE CFLMPKEQSV PNPEKDTEYT LYKKEEEIKT ENLDKCMEKT RNGEANFDC
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