ID STING_XENTR Reviewed; 329 AA.
AC A8E5V9;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 1.
DT 10-MAY-2017, entry version 53.
DE RecName: Full=Stimulator of interferon genes protein;
DE Short=STING;
DE AltName: Full=Transmembrane protein 173;
GN Name=tmem173; Synonyms=sting;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thymus;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP FUNCTION.
RX PubMed=26300263; DOI=10.1016/j.molcel.2015.07.022;
RA Kranzusch P.J., Wilson S.C., Lee A.S., Berger J.M., Doudna J.A.,
RA Vance R.E.;
RT "Ancient origin of cGAS-STING reveals mechanism of universal 2',3'
RT cGAMP signaling.";
RL Mol. Cell 59:891-903(2015).
CC -!- FUNCTION: Facilitator of innate immune signaling that acts as a
CC sensor of cytosolic DNA from bacteria and viruses and promotes the
CC production of type I interferon (IFN-alpha and IFN-beta). Innate
CC immune response is triggered in response to non-CpG double-
CC stranded DNA from viruses and bacteria delivered to the cytoplasm.
CC Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second
CC messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a
CC messenger produced in response to DNA virus in the cytosol: upon
CC binding of c-di-GMP or cGAMP, autoinhibition is alleviated and
CC TMEM173/STING is able to activate both NF-kappa-B and IRF3
CC transcription pathways to induce expression of type I interferon
CC and exert a potent anti-viral state (By similarity). Can bind 2'-
CC 3' linked cGAMP but not 3'-3' linked cGAMP (PubMed:26300263).
CC {ECO:0000250|UniProtKB:Q86WV6, ECO:0000269|PubMed:26300263}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q86WV6}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q86WV6}; Multi-pass membrane protein
CC {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q3TBT3};
CC Multi-pass membrane protein {ECO:0000255}. Mitochondrion outer
CC membrane {ECO:0000250|UniProtKB:Q86WV6}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the TMEM173 family. {ECO:0000305}.
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DR EMBL; BC153736; AAI53737.1; -; mRNA.
DR RefSeq; NP_001106445.2; NM_001112974.1.
DR UniGene; Str.62876; -.
DR SMR; A8E5V9; -.
DR STRING; 8364.ENSXETP00000055434; -.
DR PaxDb; A8E5V9; -.
DR GeneID; 100127621; -.
DR KEGG; xtr:100127621; -.
DR CTD; 340061; -.
DR Xenbase; XB-GENE-5880492; tmem173.
DR eggNOG; ENOG410IH2R; Eukaryota.
DR eggNOG; ENOG4111M85; LUCA.
DR HOGENOM; HOG000076316; -.
DR HOVERGEN; HBG094065; -.
DR InParanoid; A8E5V9; -.
DR KO; K12654; -.
DR Proteomes; UP000008143; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035438; F:cyclic-di-GMP binding; ISS:UniProtKB.
DR GO; GO:0061507; F:cyclic-GMP-AMP binding; IDA:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0002218; P:activation of innate immune response; ISS:UniProtKB.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; ISS:UniProtKB.
DR GO; GO:0045087; P:innate immune response; ISS:UniProtKB.
DR GO; GO:0032608; P:interferon-beta production; ISS:UniProtKB.
DR GO; GO:0032481; P:positive regulation of type I interferon production; IEA:InterPro.
DR CDD; cd12146; STING_C; 1.
DR InterPro; IPR029158; STING.
DR InterPro; IPR033952; STING_C.
DR Pfam; PF15009; TMEM173; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Cell membrane; Complete proteome; Endoplasmic reticulum;
KW Immunity; Innate immunity; Membrane; Mitochondrion;
KW Mitochondrion outer membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1 329 Stimulator of interferon genes protein.
FT /FTId=PRO_0000355181.
FT TRANSMEM 5 27 Helical. {ECO:0000255}.
FT TRANSMEM 68 88 Helical. {ECO:0000255}.
FT TRANSMEM 98 118 Helical. {ECO:0000255}.
FT REGION 135 325 c-di-GMP-binding domain (CBD).
FT {ECO:0000250|UniProtKB:Q86WV6}.
FT REGION 144 149 c-di-GMP binding.
FT {ECO:0000250|UniProtKB:Q86WV6}.
FT REGION 220 223 c-di-GMP binding.
FT {ECO:0000250|UniProtKB:Q86WV6}.
FT BINDING 245 245 c-di-GMP. {ECO:0000250|UniProtKB:Q86WV6}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 29 322 ipfam:TMEM173 [T]
SQ SEQUENCE 329 AA; 37815 MW; 66F389EB83EC7199 CRC64;
MACVLAIGSI LFVWILGKGK YSGAQLIYRM ATNFAISQGC CLVTCACELT EEIKHLHTRY
NGHYWRALKA SFNLSCAAFV TAILCYVFYE PKLMASLPLT IDITLTLLSW LFCWILGIQG
PTPATISEIT EIKQLNVAHG LAWSYYVGYL QFVLPALKES IQKFNEENHN LLKFPETCRL
HILIPLSCRL YGDLKDVDEN ITFLKEIPPL YIDRAGIKGR VFKNNVYRIL DEDGRPYNCI
VEYATPLASL LKMTDIPSAA FSADDRLQQT KLFYRTLKDI LENAHELQNT YRLIVYEDFP
ETKDHSRHLL SQEILKHIRQ QHSEEYSML
//
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