Entry euk:SRRM4_DANRE

ID   SRRM4_DANRE             Reviewed;         574 AA.
AC   P0CB65;
DT   15-DEC-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2009, sequence version 1.
DT   15-MAR-2017, entry version 24.
DE   RecName: Full=Serine/arginine repetitive matrix protein 4;
DE   AltName: Full=Neural-specific serine/arginine repetitive splicing factor of 100 kDa;
DE            Short=ZnSR100;
DE            Short=nSR100;
GN   Name=srrm4;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G.,
RA   Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B.,
RA   Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S.,
RA   Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C.,
RA   Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H.,
RA   Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C.,
RA   Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J.,
RA   Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S.,
RA   Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R.,
RA   Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R.,
RA   Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R.,
RA   Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A.,
RA   Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S.,
RA   Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   IDENTIFICATION, FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=19737518; DOI=10.1016/j.cell.2009.06.012;
RA   Calarco J.A., Superina S., O'Hanlon D., Gabut M., Raj B., Pan Q.,
RA   Skalska U., Clarke L., Gelinas D., van der Kooy D., Zhen M.,
RA   Ciruna B., Blencowe B.J.;
RT   "Regulation of vertebrate nervous system alternative splicing and
RT   development by an SR-related protein.";
RL   Cell 138:898-910(2009).
CC   -!- FUNCTION: Splicing factor specifically required for neural cell
CC       differentiation. Acts in conjuction with nPTB/PTBP2 by binding
CC       directly to its regulated target transcripts and promotes neural-
CC       specific exon inclusion in many genes that function in neural cell
CC       differentiation. Required to promote the inclusion of neural-
CC       specific exon 10 in nPTB/PTBP2, leading to increased expression of
CC       neural-specific nPTB/PTBP2 (By similarity). {ECO:0000250,
CC       ECO:0000269|PubMed:19737518}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: At 24 hour postfertilization (hpf),
CC       significant expression is observed in the developing brain,
CC       including the tectum and telencephalon. Expression is also
CC       observed around the trigeminal ganglion, at the mid-hindbrain
CC       boundary, and throughout the hindbrain. At 36 hpf, additional
CC       expression is observed in the cerebellum and within the retina. At
CC       48 hpf, stronger and more widespread expression is detected
CC       throughout the developing eyes brain.
CC       {ECO:0000269|PubMed:19737518}.
CC   -!- SIMILARITY: Belongs to the nSR100 family. {ECO:0000305}.
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DR   EMBL; BX649391; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   UniGene; Dr.109634; -.
DR   SMR; P0CB65; -.
DR   PRIDE; P0CB65; -.
DR   ZFIN; ZDB-GENE-050208-34; srrm4.
DR   InParanoid; P0CB65; -.
DR   PRO; PR:P0CB65; -.
DR   Proteomes; UP000000437; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003729; F:mRNA binding; ISS:UniProtKB.
DR   GO; GO:0007409; P:axonogenesis; IMP:ZFIN.
DR   GO; GO:0030154; P:cell differentiation; IMP:UniProtKB.
DR   GO; GO:0006397; P:mRNA processing; IMP:UniProtKB.
DR   GO; GO:0007399; P:nervous system development; IMP:UniProtKB.
DR   GO; GO:0043484; P:regulation of RNA splicing; IMP:UniProtKB.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR029360; SRRM_C.
DR   Pfam; PF15230; SRRM_C; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Differentiation; mRNA processing; mRNA splicing;
KW   Nucleus; Reference proteome; RNA-binding.
FT   CHAIN         1    574       Serine/arginine repetitive matrix protein
FT                                4.
FT                                /FTId=PRO_0000390460.
FT   COMPBIAS    103    169       Lys-rich.
FT   COMPBIAS    120    570       Ser-rich.
FT   COMPBIAS    371    574       Arg-rich.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       440    501       ipfam:SRRM_C [T]
SQ   SEQUENCE   574 AA;  65522 MW;  796F37459D4569C4 CRC64;
     MAGVQQGEKQ LFEKFWRGTF KAVATPRPES IIVASITARR AVTKLETPVG PKDDEEKVKA
     KDLVTKTHEK NGHIKRRGRK RHSHRRARSV SFDADLSPRP VPKTKKKKKK SQRKRRRHRS
     PSCSPSPVRK KKKKKSSKKR KRHRSASRKG RHSGSSSRRK RKEDKKHKKR SRSHSHRRHR
     HRKAEIRSSS CMENRSEDCE KSGFRDGGRS SDVHGGDACR SAVKLTNKIS SKCCCHFSES
     TVSPSRSGVE GLSKVVIVQN SESSDGKRRA DYDSGNDTSS PPSSKTGITR SKVAGNGKFS
     CLTSPEKLRL ADGDNASDSG NSLTSYDSLG KPLLRENTLH SSVFSKLKGE ESGRFCVDVE
     KTQPLDLISD RNRSPSHDRY EDGTRSRSRS ISSQSRYSGR HSRSRSLSSG RRSYSRSSSY
     SLASRRDSLS SVSSCRSLNH SRCTTHRFRE RKRYCSSCKS RKHSRRRPSS PMRKRRRDSP
     SHLEARRITS ARKRPIPYYR PSPSVSSRSS SILSWRLFPL TRSRTRSRSC SRSRSRSHSH
     TYSSYRSYSR SSSWNSLYSR RSRSRSRSYS RARR
//