Entry euk:SND1_DANRE

ID   SND1_DANRE              Reviewed;         897 AA.
AC   Q7ZT42; Q6DEI2; Q7SX79; Q7ZZS7; Q8AXL0;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   10-MAY-2017, entry version 106.
DE   RecName: Full=Staphylococcal nuclease domain-containing protein 1;
DE   AltName: Full=100 kDa coactivator;
DE   AltName: Full=4SNc-Tudor domain protein;
DE   AltName: Full=p100 co-activator;
GN   Name=snd1; Synonyms=sn4tdr;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), SUBCELLULAR LOCATION,
RP   AND DEVELOPMENTAL STAGE.
RX   PubMed=12753931; DOI=10.1016/S0014-5793(03)00445-9;
RA   Zhao C.T., Shi K.H., Su Y., Liang L.Y., Yan Y., Postlethwait J.,
RA   Meng A.M.;
RT   "Two variants of zebrafish p100 are expressed during embryogenesis and
RT   regulated by Nodal signaling.";
RL   FEBS Lett. 543:190-195(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Abe S., Wang P.;
RT   "Danio rerio full mRNA for 4SNc-Tudor domain protein, complete cds.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12753931}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q7ZT42-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q7ZT42-2; Sequence=VSP_012670;
CC       Name=3;
CC         IsoId=Q7ZT42-3; Sequence=VSP_012671, VSP_012669;
CC   -!- DEVELOPMENTAL STAGE: During the blastula period expressed in all
CC       blastomeres. At the onset of gastrulation, expressed more in the
CC       embryonic shield than in other regions. As embryos elongate,
CC       expression in the shield migrates toward the animal pole and forms
CC       a longitudinal band in the dorsal midline. At late gastrulation,
CC       expressed in the dorsal midline extending from the tailbud to the
CC       animal pole. Expression is under the control of Nodal signals.
CC       {ECO:0000269|PubMed:12753931}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH77133.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAN76663.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAP23062.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAC76713.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAC76779.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AY272050; AAP23062.1; ALT_INIT; mRNA.
DR   EMBL; AF422806; AAN76663.2; ALT_INIT; mRNA.
DR   EMBL; AB098074; BAC56985.1; -; mRNA.
DR   EMBL; AB110096; BAC76712.1; -; mRNA.
DR   EMBL; AB110096; BAC76713.1; ALT_INIT; mRNA.
DR   EMBL; AB110445; BAC76779.1; ALT_INIT; mRNA.
DR   EMBL; BC077133; AAH77133.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001280610.1; NM_001293681.1. [Q7ZT42-3]
DR   UniGene; Dr.76177; -.
DR   ProteinModelPortal; Q7ZT42; -.
DR   SMR; Q7ZT42; -.
DR   STRING; 7955.ENSDARP00000040404; -.
DR   PaxDb; Q7ZT42; -.
DR   PeptideAtlas; Q7ZT42; -.
DR   PRIDE; Q7ZT42; -.
DR   Ensembl; ENSDART00000100974; ENSDARP00000091746; ENSDARG00000006766. [Q7ZT42-3]
DR   GeneID; 324404; -.
DR   KEGG; dre:324404; -.
DR   CTD; 27044; -.
DR   ZFIN; ZDB-GENE-030131-3124; snd1.
DR   eggNOG; KOG2039; Eukaryota.
DR   eggNOG; COG1525; LUCA.
DR   GeneTree; ENSGT00510000047270; -.
DR   HOGENOM; HOG000173592; -.
DR   HOVERGEN; HBG057234; -.
DR   InParanoid; Q7ZT42; -.
DR   KO; K15979; -.
DR   PRO; PR:Q7ZT42; -.
DR   Proteomes; UP000000437; Chromosome 4.
DR   Bgee; ENSDARG00000006766; -.
DR   ExpressionAtlas; Q7ZT42; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IDA:ZFIN.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016442; C:RISC complex; IEA:InterPro.
DR   GO; GO:0004518; F:nuclease activity; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:InterPro.
DR   GO; GO:0006401; P:RNA catabolic process; IBA:GO_Central.
DR   InterPro; IPR016685; Silence_cplx_Nase-comp_TudorSN.
DR   InterPro; IPR016071; Staphylococal_nuclease_OB-fold.
DR   InterPro; IPR002071; Thermonucl_AS.
DR   InterPro; IPR002999; Tudor.
DR   Pfam; PF00565; SNase; 4.
DR   Pfam; PF00567; TUDOR; 1.
DR   PIRSF; PIRSF017179; RISC-Tudor-SN; 1.
DR   SMART; SM00318; SNc; 4.
DR   SMART; SM00333; TUDOR; 1.
DR   SUPFAM; SSF50199; SSF50199; 6.
DR   PROSITE; PS01284; TNASE_2; 1.
DR   PROSITE; PS50830; TNASE_3; 4.
DR   PROSITE; PS50304; TUDOR; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Cytoplasm;
KW   Reference proteome; Repeat.
FT   CHAIN         1    897       Staphylococcal nuclease domain-containing
FT                                protein 1.
FT                                /FTId=PRO_0000183183.
FT   DOMAIN       18    167       TNase-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00272}.
FT   DOMAIN      194    329       TNase-like 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00272}.
FT   DOMAIN      342    499       TNase-like 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00272}.
FT   DOMAIN      528    663       TNase-like 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00272}.
FT   DOMAIN      732    790       Tudor. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00211}.
FT   VAR_SEQ     561    574       IECPRGSRNMPGGM -> KCQPASACQLYHHL (in
FT                                isoform 3).
FT                                {ECO:0000303|PubMed:12753931}.
FT                                /FTId=VSP_012671.
FT   VAR_SEQ     575    897       Missing (in isoform 3).
FT                                {ECO:0000303|PubMed:12753931}.
FT                                /FTId=VSP_012669.
FT   VAR_SEQ     897    897       R -> RYGDFRDDDADEFGYRR (in isoform 2).
FT                                {ECO:0000303|PubMed:12753931,
FT                                ECO:0000303|Ref.3}.
FT                                /FTId=VSP_012670.
FT   CONFLICT    606    606       I -> K (in Ref. 1; AAP23062 and 3;
FT                                AAH77133). {ECO:0000305}.
FT   CONFLICT    612    612       D -> G (in Ref. 1; AAP23062 and 3;
FT                                AAH77133). {ECO:0000305}.
FT   CONFLICT    617    617       D -> E (in Ref. 1; AAP23062 and 3;
FT                                AAH77133). {ECO:0000305}.
FT   CONFLICT    643    643       Y -> C (in Ref. 3; AAH77133).
FT                                {ECO:0000305}.
FT   CONFLICT    669    669       N -> K (in Ref. 1; AAP23062 and 3;
FT                                AAH77133). {ECO:0000305}.
FT   CONFLICT    682    691       GRNTDPSTSL -> VAKYRSVYVT (in Ref. 1;
FT                                AAP23062 and 3). {ECO:0000305}.
FT   CONFLICT    753    753       V -> F (in Ref. 1; AAP23062).
FT                                {ECO:0000305}.
FT   CONFLICT    838    838       M -> S (in Ref. 1; AAP23062 and 3;
FT                                AAH77133). {ECO:0000305}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       342    499       ismart:SNc [T]
FT   MYHIT        18    167       iprf:TNASE_3 [T]
FT   MYHIT       194    329       iprf:TNASE_3 [T]
FT   MYHIT       342    499       iprf:TNASE_3 [T]
FT   MYHIT       194    329       ismart:SNc [T]
FT   MYHIT       528    663       iprf:TNASE_3 [T]
FT   MYHIT       556    662       ipfam:SNase [T]
FT   MYHIT       692    801       ipfam:TUDOR [T]
FT   MYHIT        18    167       ismart:SNc [T]
FT   MYHIT       221    329       ipfam:SNase [T]
FT   MYHIT       369    498       ipfam:SNase [T]
FT   MYHIT       732    790       iprf:TUDOR [T]
FT   MYHIT       103    113       ipat:TNASE_2 [T]
FT   MYHIT        68    167       ipfam:SNase [T]
FT   MYHIT       731    788       ismart:TUDOR [T]
FT   MYHIT       528    663       ismart:SNc [T]
SQ   SEQUENCE   897 AA;  100535 MW;  367B9B6428C306A3 CRC64;
     MASAVPAQVQ SSQASAPQLQ RGIVKMVLSG CAIIVRGQPR GGPPPERQIN LSNIRAGALA
     RRAIQGQPDT KDTPDEPWAF QAREFMRKKV IGKEVCFTVE NKTPQGREYG MVYLGKDTSG
     ENIAESLVAE GLAMVRREGI RGNNPEQVRL CDLEDQAKSS KKGLWSEGGG SHTIRDLKYT
     IENPRNFVDS LHQKPVNAII EHVRDGCMVR ALLLPDYYLV TVMLSGIKSP TFKREADGSE
     TPEPFAAEAK FFTESRLLQR DVQIILESCP NQVILGTILH PNGNITELLL KEGFARCVDW
     SMAVYTQGAE KLRAAERSAK ERKVRIWKDY VAPTANLDQK DRQFVAKVMQ VVNADAIVVK
     LNSGEYKTIH LSSIRPPRLE GEEKNKDKDK RFRPLYDIPY MFEAREFLRK KLIGKKVNVT
     VDYIRAATNA MEMGVPAFPE RTCATVTIGG INIAEALVSK GLATVIRYRQ DDDQRSSHYD
     ELLAAEARAI KNGKGLHSKK EVPIHRVADI SGETQKAKQF FPFLQRAGRS EAVVEYVFSG
     SRLKLYMPKE TCLITFLLAG IECPRGSRNM PGGMQVAEPY SEEAMLFTKE LVLQREVEVE
     VESMDIAGNF IDWLHIDGVN LSVALVENAL SKVHFTAERS SYYKTLVSAE ESARQRKEKL
     WANYEEKPNE EVAQVTEAKE RGRNTDPSTS LEITDGLHFY AQDVETGTKL ENLMESMRGE
     IAAQPPVEGS FAPRRGEFCI AKFADGEWYR ARVEKVESPA KVHVFYIDYG NREVLSSTRL
     AALPPAFSTR TLPPQATEYA FAYIQVPQDE DARADAVDSV VRDIHNTQCL LNVEYSGMVC
     PQVTLQFADT KEDVGLGLVK EGMVMVDIRK EKYLQKMVTE YLNAQESAKS ARLNIWR
//