ID SG494_HUMAN Reviewed; 274 AA.
AC Q96LW2; B4DFP4; Q49A48;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 15-MAR-2017, entry version 115.
DE RecName: Full=Uncharacterized serine/threonine-protein kinase SgK494;
DE EC=2.7.11.1;
DE AltName: Full=Sugen kinase 494;
GN Name=SGK494;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Amygdala, and Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=12471243; DOI=10.1126/science.1075762;
RA Manning G., Whyte D.B., Martinez R., Hunter T., Sudarsanam S.;
RT "The protein kinase complement of the human genome.";
RL Science 298:1912-1934(2002).
CC -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96LW2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96LW2-2; Sequence=VSP_020678, VSP_020679;
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr
CC protein kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR EMBL; AK057735; BAB71555.1; -; mRNA.
DR EMBL; AK294189; BAG57505.1; -; mRNA.
DR EMBL; BC045622; AAH45622.1; -; mRNA.
DR UniGene; Hs.729077; -.
DR ProteinModelPortal; Q96LW2; -.
DR SMR; Q96LW2; -.
DR STRING; 9606.ENSP00000301037; -.
DR DMDM; 74724242; -.
DR PaxDb; Q96LW2; -.
DR PRIDE; Q96LW2; -.
DR GeneCards; SGK494; -.
DR HPA; HPA046590; -.
DR neXtProt; NX_Q96LW2; -.
DR OpenTargets; ENSG00000258472; -.
DR eggNOG; KOG0694; Eukaryota.
DR eggNOG; ENOG410XNPH; LUCA.
DR GeneTree; ENSGT00400000022377; -.
DR HOGENOM; HOG000154304; -.
DR HOVERGEN; HBG093948; -.
DR InParanoid; Q96LW2; -.
DR PhylomeDB; Q96LW2; -.
DR SignaLink; Q96LW2; -.
DR ChiTaRS; SGK494; human.
DR PRO; PR:Q96LW2; -.
DR Proteomes; UP000005640; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR InterPro; IPR011009; Kinase-like_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Complete proteome; Kinase;
KW Nucleotide-binding; Reference proteome;
KW Serine/threonine-protein kinase; Transferase.
FT CHAIN 1 274 Uncharacterized serine/threonine-protein
FT kinase SgK494.
FT /FTId=PRO_0000250646.
FT DOMAIN 107 274 Protein kinase. {ECO:0000255|PROSITE-
FT ProRule:PRU00159}.
FT NP_BIND 113 121 ATP. {ECO:0000255|PROSITE-
FT ProRule:PRU00159}.
FT ACT_SITE 229 229 Proton acceptor. {ECO:0000255|PROSITE-
FT ProRule:PRU00159, ECO:0000255|PROSITE-
FT ProRule:PRU10027}.
FT BINDING 136 136 ATP. {ECO:0000255|PROSITE-
FT ProRule:PRU00159}.
FT VAR_SEQ 160 171 RQINHPFVHSLG -> VISMTWASCIEM (in isoform
FT 2). {ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_020678.
FT VAR_SEQ 172 274 Missing (in isoform 2).
FT {ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_020679.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 107 274 iprf:PROTEIN_KINASE_DOM [T]
FT MYHIT 225 237 ipat:PROTEIN_KINASE_ST [T]
FT MYHIT 107 273 ismart:S_TKc [T]
FT MYHIT 113 271 ipfam:Pkinase [T]
SQ SEQUENCE 274 AA; 31044 MW; 078726BA9DE13670 CRC64;
MGAVSCRQGQ HTQQGEHTRV AVPHKQGGNI RGPWARGWKS LWTGLGTIRS DLEELWELRG
HHYLHQESLK PAPVLVEKPL PEWPVPQFIN LFLPEFPIRP IRGQQQLKIL GLVAKGSFGT
VLKVLDCTQK AVFAVKVVPK VKVLQRDTVR QCKEEVSIQR QINHPFVHSL GDSWQGKRHL
FIMCSYCSTD LYSLWSAVGC FPEASIRLFA AELVLVLCYL HDLGIMHRDV KMENILLDER
GHLKLTDFGL SRHVPQGAQA YTICGTLQYM GERG
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