ID RN103_RAT Reviewed; 682 AA.
AC Q9EPZ8;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 10-MAY-2017, entry version 94.
DE RecName: Full=E3 ubiquitin-protein ligase RNF103;
DE EC=2.3.2.27;
DE AltName: Full=Protein ADRG34;
DE AltName: Full=RING finger protein 103;
DE AltName: Full=RING-type E3 ubiquitin transferase RNF103 {ECO:0000305};
DE AltName: Full=Zinc finger protein 103;
DE Short=Zfp-103;
GN Name=Rnf103; Synonyms=Zfp103;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=11071867; DOI=10.1006/bbrc.2000.3773;
RA Yamada M., Yamada M., Yamazaki S., Takahashi K., Nishioka G., Kudo K.,
RA Ozawa H., Yamada S., Kiuchi Y., Kamijima K., Higuchi T., Momose K.;
RT "Identification of a novel gene with RING-H2 finger motif induced
RT after chronic antidepressant treatment in rat brain.";
RL Biochem. Biophys. Res. Commun. 278:150-157(2000).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=18675248; DOI=10.1016/j.bbrc.2008.07.126;
RA Maruyama Y., Yamada M., Takahashi K., Yamada M.;
RT "Ubiquitin ligase Kf-1 is involved in the endoplasmic reticulum-
RT associated degradation pathway.";
RL Biochem. Biophys. Res. Commun. 374:737-741(2008).
CC -!- FUNCTION: Acts as an E2-dependent E3 ubiquitin-protein ligase,
CC probably involved in the ER-associated protein degradation
CC pathway. {ECO:0000250|UniProtKB:O00237}.
CC -!- CATALYTIC ACTIVITY: S-ubiquitinyl-[E2 ubiquitin-conjugating
CC enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-
CC conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor
CC protein]-L-lysine.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Interacts with DERL1 and VCP.
CC {ECO:0000250|UniProtKB:O00237}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:O00237}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:O00237}.
CC -!- TISSUE SPECIFICITY: Expressed in different tissues including
CC hippocampus, cerebral cortex, heart, kidney, spleen and lung.
CC Expression is increased in hippocampus and frontal cortex after
CC chronic treatment with antidepressants.
CC {ECO:0000269|PubMed:11071867, ECO:0000269|PubMed:18675248}.
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DR EMBL; AF306394; AAG37065.1; -; mRNA.
DR UniGene; Rn.45685; -.
DR ProteinModelPortal; Q9EPZ8; -.
DR SMR; Q9EPZ8; -.
DR STRING; 10116.ENSRNOP00000062726; -.
DR PaxDb; Q9EPZ8; -.
DR UCSC; RGD:620586; rat.
DR RGD; 620586; Rnf103.
DR eggNOG; KOG0800; Eukaryota.
DR eggNOG; ENOG41121N2; LUCA.
DR HOGENOM; HOG000006578; -.
DR HOVERGEN; HBG054144; -.
DR InParanoid; Q9EPZ8; -.
DR BRENDA; 2.3.2.B10; 5301.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q9EPZ8; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; ISS:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR CDD; cd00162; RING; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Endoplasmic reticulum; Membrane; Metal-binding;
KW Reference proteome; Transferase; Transmembrane; Transmembrane helix;
KW Ubl conjugation pathway; Zinc; Zinc-finger.
FT CHAIN 1 682 E3 ubiquitin-protein ligase RNF103.
FT /FTId=PRO_0000056086.
FT TRANSMEM 6 26 Helical. {ECO:0000255}.
FT TRANSMEM 326 346 Helical. {ECO:0000255}.
FT TRANSMEM 366 386 Helical. {ECO:0000255}.
FT TRANSMEM 411 431 Helical. {ECO:0000255}.
FT ZN_FING 618 660 RING-type. {ECO:0000255|PROSITE-
FT ProRule:PRU00175}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 617 660 ipfam:zf-RING_2 [T]
FT MYHIT 618 659 ismart:RING [T]
FT MYHIT 618 660 iprf:ZF_RING_2 [T]
SQ SEQUENCE 682 AA; 79019 MW; 77C5462F0EA271B5 CRC64;
MWLKLFFLLL YFLVLFVLAR FFEAIVWYET GIFATQLVDP VALSFKKLKT ILECRGLGYS
GLPEKKDVRE LVEKSGDLME GELYSALKEE EASESVSSTN FSGEMHFYEL VEDTKDGIWL
VQVIANDRSP LVGKIHWEKM VKKVSRFGIR TGTFNCSSDP RYCRRRGWVR STLIMSVPQT
STSKGKVMLK EYSGRKIEVE HIFKWITAHA ASRIKTIYNV EHLKEEWNKS DQYWVKIYLF
ANLDQPPAFF SALSIKFTGR VEFIFVNVEN WNNKSYMTDI GIYNMPSYIL RTPEGIYRYG
NHTGEFISLQ AMDSFLRSLQ PEVNDLFVLS LVLVNLMAWM DLFITQGATI KRFVVLISTL
GTYNSLLIIS WLPVLGFLQL PYLDSFYEYS LRLLRYSNTT TLASWVRADW MFYSSHPALF
LSTYLGHGLL IDYFEKKRRR SNNDEVNANN LEWLSSLWDW YTSYLFHPIA SFQNFPVDSD
WDEDPDLFLE RLAFPDLWLH PLIPTDYIKN LPMWRFKCLG AQSEEEMSES SQDTENDSDS
DNTDTFSSSK DVFEDKQNVH SSPGRTSRCD TEACSCANKC VSSPCERKRR SYGSHNTKED
MEPDWLTWPA GTLHCTECVV CLENFENGCL LMGLPCGHVF HQNCIVMWLA GGRHCCPVCR
WPSYKKKQPY AQQQPLSNDA PS
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