Entry euk:R4GKM9_CHICK

ID   R4GKM9_CHICK            Unreviewed;       351 AA.
AC   R4GKM9;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   10-MAY-2017, entry version 26.
DE   SubName: Full=G-protein coupled receptor 139 {ECO:0000313|EMBL:AMQ09602.1};
GN   Name=GPR139 {ECO:0000313|EMBL:AMQ09602.1,
GN   ECO:0000313|Ensembl:ENSGALP00000042731};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000042731, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00000042731, ECO:0000313|Proteomes:UP000000539}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000042731,
RC   ECO:0000313|Proteomes:UP000000539};
RX   PubMed=15592404; DOI=10.1038/nature03154;
RG   International Chicken Genome Sequencing Consortium;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
RA   Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
RA   Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
RA   Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
RA   Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
RA   Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
RA   Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
RA   Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
RA   Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
RA   Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
RA   van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
RA   Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
RA   Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
RA   Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
RA   Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
RA   Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
RA   Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
RA   Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
RA   King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
RA   Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
RA   Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
RA   Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
RA   Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
RA   Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
RA   Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
RA   Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
RA   Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
RA   Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
RA   Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
RA   Mardis E.R., Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide
RT   unique perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
RN   [2] {ECO:0000313|Ensembl:ENSGALP00000042731}
RP   IDENTIFICATION.
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000042731};
RG   Ensembl;
RL   Submitted (MAY-2013) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:AMQ09602.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26349500; DOI=10.1124/mol.115.100412;
RA   Liu C., Bonaventure P., Lee G., Nepomuceno D., Kuei C., Wu J., Li Q.,
RA   Joseph V., Sutton S.W., Eckert W., Yao X., Yieh L., Dvorak C.,
RA   Carruthers N., Coate H., Yun S., Dugovic C., Harrington A.,
RA   Lovenberg T.W.;
RT   "GPR139, an Orphan Receptor Highly Enriched in the Habenula and
RT   Septum, Is Activated by the Essential Amino Acids L-Tryptophan and L-
RT   Phenylalanine.";
RL   Mol. Pharmacol. 88:911-925(2015).
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DR   EMBL; AADN04000521; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KR081946; AMQ09602.1; -; mRNA.
DR   RefSeq; NP_001308664.1; NM_001321735.1.
DR   STRING; 9031.ENSGALP00000003138; -.
DR   PaxDb; R4GKM9; -.
DR   Ensembl; ENSGALT00000044220; ENSGALP00000042731; ENSGALG00000027146.
DR   GeneID; 431418; -.
DR   KEGG; gga:431418; -.
DR   CTD; 124274; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   eggNOG; ENOG410XRW9; LUCA.
DR   GeneTree; ENSGT00390000006613; -.
DR   KO; K08428; -.
DR   OMA; FPVSHHN; -.
DR   OrthoDB; EOG091G0HIF; -.
DR   Proteomes; UP000000539; Chromosome 14.
DR   Bgee; ENSGALG00000027146; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008188; F:neuropeptide receptor activity; IEA:Ensembl.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:Ensembl.
DR   GO; GO:0007200; P:phospholipase C-activating G-protein coupled receptor signaling pathway; IEA:Ensembl.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000539};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:AMQ09602.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     28     49       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     61     84       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    104    126       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    146    164       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    180    206       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    227    251       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    263    286       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       41    283       G_PROTEIN_RECEP_F1_2.
FT                                {ECO:0000259|PROSITE:PS50262}.
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CC   The following FT lines are automated annotations from the MyHits database.
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FT   MYHIT        42    283       ipfam:7tm_1 [T]
FT   MYHIT        41    283       iprf:G_PROTEIN_RECEP_F1_2 [T]
SQ   SEQUENCE   351 AA;  40705 MW;  A09E88885889522E CRC64;
     MEHNHLHLHN GSLVPHHRYG CGLGYAPVVY YSLLLCLGLP ANILTVIILS QLVARRQKSS
     YNYLLALAAA DILVLFFIVF VDFLMEDFIL NKQMPQVLDK IIEVLEFSSI HTSIWITVPL
     TIDRYIAVCH PLKYHTVSYP ARTRKVIVSV YITCFLTSIP YYWWPNIWIE DYISTSMHHV
     LIWIHCFTVY LVPCSIFFIL NSIIVYKLRR KSNFRLRGYS TGKTTAILFT ITSIFAILWA
     PRIIMILYHL YVSPINNSWV VHIVSDIANM LALLNTAINF FLYCFISKRF RTMAAATLKA
     FFKCQKQPVQ FYTNHNFSIT SSPWISPANS HCIKMLVYQY DKNGKPIKIS P
//