ID QRFPR_RAT Reviewed; 433 AA.
AC P83858;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 1.
DT 10-MAY-2017, entry version 101.
DE RecName: Full=Pyroglutamylated RFamide peptide receptor;
DE AltName: Full=AQ27;
DE AltName: Full=G-protein coupled receptor 103;
DE AltName: Full=Orexigenic neuropeptide QRFP receptor;
DE AltName: Full=SP9155;
GN Name=Qrfpr; Synonyms=Gpr103;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000312|EMBL:BAC98939.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12714592; DOI=10.1074/jbc.M302945200;
RA Jiang Y., Luo L., Gustafson E.L., Yadav D., Laverty M., Murgolo N.,
RA Vassileva G., Zeng M., Laz T.M., Behan J., Qiu P., Wang L., Wang S.,
RA Bayne M., Greene J., Monsma F.J. Jr., Zhang F.L.;
RT "Identification and characterization of a novel RF-amide peptide
RT ligand for orphan G-protein-coupled receptor SP9155.";
RL J. Biol. Chem. 278:27652-27657(2003).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Brain {ECO:0000269|PubMed:12960173};
RX PubMed=12960173; DOI=10.1074/jbc.M305270200;
RA Fukusumi S., Yoshida H., Fujii R., Maruyama M., Komatsu H., Habata Y.,
RA Shintani Y., Hinuma S., Fujino M.;
RT "A new peptidic ligand and its receptor regulating adrenal function in
RT rats.";
RL J. Biol. Chem. 278:46387-46395(2003).
RN [3]
RP FUNCTION.
RX PubMed=16648250; DOI=10.1073/pnas.0602371103;
RA Takayasu S., Sakurai T., Iwasaki S., Teranishi H., Yamanaka A.,
RA Williams S.C., Iguchi H., Kawasawa Y.I., Ikeda Y., Sakakibara I.,
RA Ohno K., Ioka R.X., Murakami S., Dohmae N., Xie J., Suda T.,
RA Motoike T., Ohuchi T., Yanagisawa M., Sakai J.;
RT "A neuropeptide ligand of the G protein-coupled receptor GPR103
RT regulates feeding, behavioral arousal, and blood pressure in mice.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:7438-7443(2006).
CC -!- FUNCTION: Receptor for the orexigenic neuropeptide QRFP. The
CC activity of this receptor is mediated by G proteins that modulate
CC adenylate cyclase activity and intracellular calcium levels.
CC {ECO:0000269|PubMed:16648250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Highly expressed in the adrenal gland and at
CC moderate levels in the eye and testis. Expressed widely in the
CC brain with high levels in the hypothalamus and moderate levels in
CC the amygdala, basal forebrain, cortex, medulla oblongata, midbrain
CC and thalamus. {ECO:0000269|PubMed:12960173}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AB109630; BAC98939.1; -; mRNA.
DR RefSeq; NP_937842.1; NM_198199.1.
DR UniGene; Rn.162584; -.
DR ProteinModelPortal; P83858; -.
DR STRING; 10116.ENSRNOP00000035152; -.
DR ChEMBL; CHEMBL1949484; -.
DR GuidetoPHARMACOLOGY; 333; -.
DR PhosphoSitePlus; P83858; -.
DR PaxDb; P83858; -.
DR PRIDE; P83858; -.
DR Ensembl; ENSRNOT00000039615; ENSRNOP00000035152; ENSRNOG00000014414.
DR GeneID; 310327; -.
DR KEGG; rno:310327; -.
DR UCSC; RGD:728380; rat.
DR CTD; 84109; -.
DR RGD; 728380; Qrfpr.
DR eggNOG; KOG3656; Eukaryota.
DR eggNOG; ENOG410XRW9; LUCA.
DR GeneTree; ENSGT00760000118781; -.
DR HOGENOM; HOG000136537; -.
DR HOVERGEN; HBG067831; -.
DR InParanoid; P83858; -.
DR KO; K08378; -.
DR OMA; HAIMNIT; -.
DR OrthoDB; EOG091G0976; -.
DR PhylomeDB; P83858; -.
DR TreeFam; TF315303; -.
DR PRO; PR:P83858; -.
DR Proteomes; UP000002494; Chromosome 2.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0097730; C:non-motile cilium; IEA:Ensembl.
DR GO; GO:0004930; F:G-protein coupled receptor activity; ISS:UniProtKB.
DR GO; GO:0004983; F:neuropeptide Y receptor activity; IEA:InterPro.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0032870; P:cellular response to hormone stimulus; IBA:GO_Central.
DR GO; GO:0007186; P:G-protein coupled receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:1901652; P:response to peptide; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000611; NPY_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01012; NRPEPTIDEYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Complete proteome; G-protein coupled receptor;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1 433 Pyroglutamylated RFamide peptide
FT receptor.
FT /FTId=PRO_0000070099.
FT TOPO_DOM 1 46 Extracellular. {ECO:0000255}.
FT TRANSMEM 47 67 Helical; Name=1. {ECO:0000255}.
FT TOPO_DOM 68 81 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 82 102 Helical; Name=2. {ECO:0000255}.
FT TOPO_DOM 103 120 Extracellular. {ECO:0000255}.
FT TRANSMEM 121 141 Helical; Name=3. {ECO:0000255}.
FT TOPO_DOM 142 162 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 163 183 Helical; Name=4. {ECO:0000255}.
FT TOPO_DOM 184 212 Extracellular. {ECO:0000255}.
FT TRANSMEM 213 233 Helical; Name=5. {ECO:0000255}.
FT TOPO_DOM 234 271 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 272 292 Helical; Name=6. {ECO:0000255}.
FT TOPO_DOM 293 313 Extracellular. {ECO:0000255}.
FT TRANSMEM 314 334 Helical; Name=7. {ECO:0000255}.
FT TOPO_DOM 335 433 Cytoplasmic. {ECO:0000255}.
FT CARBOHYD 5 5 N-linked (GlcNAc...) asparagine.
FT {ECO:0000255}.
FT CARBOHYD 19 19 N-linked (GlcNAc...) asparagine.
FT {ECO:0000255}.
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CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 131 147 ipat:G_PROTEIN_RECEP_F1_1 [T]
FT MYHIT 62 332 ipfam:7tm_1 [T]
FT MYHIT 62 332 iprf:G_PROTEIN_RECEP_F1_2 [T]
SQ SEQUENCE 433 AA; 49311 MW; 284A1589D38F93AD CRC64;
MQALNITAEQ FSRLLSAHNL TREQFIHRYG LRPLVYTPEL PARAKVAFAL AGALIFALAL
FGNSLVIYVV TRSKAMRTVT NIFICSLALS DLLIAFFCIP VTMLQNISDK WLGGAFICKM
VPFVQSTAVV TEILTMTCIA VERHQGLVHP FKMKWQYTTR RAFTILGVVW LAAIIVGSPM
WHVQRLEIKY DFLYEKEHIC CLEEWASPVH QRIYSTFILV ILFLLPLVVM LVLYSKIGYE
LWIKKRVGDS SALQTIHGKE MSKIARKKKR AVIMMVTVVA LFAACWAPFH VVHMMVEYSN
FEKEYDDVTI KMVFAVAQTI GFFNSICNPF VYAFMNENFK KNFLSAVCYC IVKESSSPAR
KPGNSGISMM QKRAKLSRPQ RPVEETKGDT FSDASIDVKL CEQPREKRQL KRQLAFFSSE
LSENSTFGSG HEL
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