ID Q8VG49_MOUSE Unreviewed; 315 AA.
AC Q8VG49; D3Z4S1;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 10-MAY-2017, entry version 119.
DE SubName: Full=Olfactory receptor 715 {ECO:0000313|EMBL:AAI39446.1, ECO:0000313|Ensembl:ENSMUSP00000076225};
DE SubName: Full=Olfactory receptor MOR260-1 {ECO:0000313|EMBL:AAL60977.1};
GN Name=Olfr715 {ECO:0000313|EMBL:AAI39446.1,
GN ECO:0000313|Ensembl:ENSMUSP00000076225, ECO:0000313|MGI:MGI:3030549};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000313|EMBL:AAL60977.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [2] {ECO:0000313|EMBL:AAL60977.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [3] {ECO:0000313|EMBL:AAL60977.1}
RP NUCLEOTIDE SEQUENCE.
RA Adams M.;
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AAI39446.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000313|EMBL:AAI39446.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
RA Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5] {ECO:0000313|Ensembl:ENSMUSP00000076225, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000076225,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of
RT the mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [6] {ECO:0000313|Ensembl:ENSMUSP00000076225}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000076225};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [7] {ECO:0000313|Ensembl:ENSMUSP00000150168}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000150168};
RG Ensembl;
RL Submitted (DEC-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane
CC {ECO:0000256|SAAS:SAAS00521146}; Multi-pass membrane protein
CC {ECO:0000256|SAAS:SAAS00521146}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|SAAS:SAAS00591716}.
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DR EMBL; AC159287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC139445; AAI39446.1; -; mRNA.
DR EMBL; BC139446; AAI39447.1; -; mRNA.
DR EMBL; AY073314; AAL60977.1; -; Genomic_DNA.
DR RefSeq; NP_666991.1; NM_146780.2.
DR UniGene; Mm.223207; -.
DR STRING; 10090.ENSMUSP00000076225; -.
DR Ensembl; ENSMUST00000076958; ENSMUSP00000076225; ENSMUSG00000060503.
DR Ensembl; ENSMUST00000214919; ENSMUSP00000150168; ENSMUSG00000060503.
DR GeneID; 258776; -.
DR KEGG; mmu:258776; -.
DR UCSC; uc009jav.2; mouse.
DR CTD; 258776; -.
DR MGI; MGI:3030549; Olfr715.
DR eggNOG; ENOG410J8YG; Eukaryota.
DR eggNOG; ENOG411194F; LUCA.
DR GeneTree; ENSGT00820000126998; -.
DR HOGENOM; HOG000041365; -.
DR HOVERGEN; HBG017625; -.
DR KO; K04257; -.
DR OMA; SEVTIFL; -.
DR OrthoDB; EOG091G0AZH; -.
DR TreeFam; TF337251; -.
DR Reactome; R-MMU-381753; Olfactory Signaling Pathway.
DR Proteomes; UP000000589; Chromosome 7.
DR Bgee; ENSMUSG00000060503; -.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G-protein coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|SAAS:SAAS00521172};
KW Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW G-protein coupled receptor {ECO:0000256|SAAS:SAAS00529918};
KW Membrane {ECO:0000256|SAAS:SAAS00520911,
KW ECO:0000256|SAAS:SAAS00521172, ECO:0000256|SAM:Phobius};
KW Olfaction {ECO:0000256|SAAS:SAAS00521184};
KW Receptor {ECO:0000256|SAAS:SAAS00529918};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Sensory transduction {ECO:0000256|SAAS:SAAS00521184};
KW Transducer {ECO:0000256|SAAS:SAAS00529918};
KW Transmembrane {ECO:0000256|SAAS:SAAS00520911,
KW ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAAS:SAAS00520911,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26 48 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 60 78 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 98 120 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 140 158 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 197 225 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 237 259 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 271 290 Helical. {ECO:0000256|SAM:Phobius}.
FT DOMAIN 41 288 G_PROTEIN_RECEP_F1_2.
FT {ECO:0000259|PROSITE:PS50262}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 41 288 iprf:G_PROTEIN_RECEP_F1_2 [T]
SQ SEQUENCE 315 AA; 35285 MW; FA1CA3BF3A3DCDF9 CRC64;
MMQANQTQVT EFILLGLSDD PHTQKLLFIL FLGIYMVTVL GNLLLMFLVR ADSRLHTPMY
FFLCNLSLAD LCFSTNIVPQ ALIHLLSRKK TISFRRCAAQ LLLFLIFGCT QCALLAVMSY
DRYVAICNPL HYSSIMTWRV CIQLATVSWT SGILVSVVDT TFTLRLPYRG SNSIAHFFCE
APALLALAST DTQTSEMAIF LMGVVILLIP VSLILVSYGH IIVTVVKMKS AAGRFKAFST
CGSHLMVVIL FYGSAIITYM TPKSSKEQEK LVSVFYAMVT PMLNPLIYSL RNKDVKGALW
KVAMKNFSSR LRITH
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