ID Q8VG40_MOUSE Unreviewed; 315 AA.
AC Q8VG40;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 10-MAY-2017, entry version 114.
DE SubName: Full=Olfactory receptor 1176 {ECO:0000313|EMBL:AAI27993.1, ECO:0000313|Ensembl:ENSMUSP00000053353};
DE SubName: Full=Olfactory receptor MOR174-5 {ECO:0000313|EMBL:AAL60986.1};
DE SubName: Full=Olfactory receptor Olfr1176 {ECO:0000313|EMBL:AAP71587.1};
DE SubName: Full=Olfr1176 {ECO:0000313|EMBL:ALI87905.1};
GN Name=Olfr1176 {ECO:0000313|EMBL:AAI27993.1,
GN ECO:0000313|Ensembl:ENSMUSP00000053353, ECO:0000313|MGI:MGI:3031010};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000313|EMBL:AAL60986.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [2] {ECO:0000313|EMBL:AAL60986.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [3] {ECO:0000313|EMBL:AAL60986.1}
RP NUCLEOTIDE SEQUENCE.
RA Adams M.;
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AAP71587.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA Walker M., Williams E.M., Trask B.J.;
RT "Odorant receptor expressed sequence tags demonstrate olfactory
RT expression of over 400 genes, extensive alternate splicing and unequal
RT expression levels.";
RL Genome Biol. 4:R71.1-R71.13(2003).
RN [5] {ECO:0000313|EMBL:AAP71587.1}
RP NUCLEOTIDE SEQUENCE.
RA Sanders K.;
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:AAI27993.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=PCR rescued clones {ECO:0000313|EMBL:AAI27993.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
RA Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7] {ECO:0000313|Ensembl:ENSMUSP00000053353, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000053353,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of
RT the mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [8] {ECO:0000313|Ensembl:ENSMUSP00000053353}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000053353};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [9] {ECO:0000313|EMBL:ALI87905.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6 {ECO:0000313|EMBL:ALI87905.1};
RA Mainland J.D., Li Y.R., Zhou T., Liu W.L.L., Matsunami H.;
RT "Human Olfactory Receptor Responses to Odorants.";
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
RN [10] {ECO:0000313|Ensembl:ENSMUSP00000149943}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000149943};
RG Ensembl;
RL Submitted (DEC-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane
CC {ECO:0000256|SAAS:SAAS00521146}; Multi-pass membrane protein
CC {ECO:0000256|SAAS:SAAS00521146}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|SAAS:SAAS00591716}.
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DR EMBL; AL928829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC127992; AAI27993.1; -; mRNA.
DR EMBL; AY073323; AAL60986.1; -; Genomic_DNA.
DR EMBL; AY318377; AAP71587.1; -; Genomic_DNA.
DR EMBL; KP290747; ALI87905.1; -; Genomic_DNA.
DR RefSeq; NP_666982.1; NM_146771.1.
DR UniGene; Mm.377682; -.
DR STRING; 10090.ENSMUSP00000053353; -.
DR Ensembl; ENSMUST00000057439; ENSMUSP00000053353; ENSMUSG00000050023.
DR Ensembl; ENSMUST00000213778; ENSMUSP00000149943; ENSMUSG00000050023.
DR GeneID; 258767; -.
DR KEGG; mmu:258767; -.
DR UCSC; uc008kpp.1; mouse.
DR CTD; 258767; -.
DR MGI; MGI:3031010; Olfr1176.
DR eggNOG; ENOG410KFUC; Eukaryota.
DR eggNOG; ENOG4110SZP; LUCA.
DR GeneTree; ENSGT00550000074428; -.
DR HOGENOM; HOG000041364; -.
DR HOVERGEN; HBG017625; -.
DR KO; K04257; -.
DR OMA; CCEYSAI; -.
DR OrthoDB; EOG091G0AZH; -.
DR TreeFam; TF352746; -.
DR Proteomes; UP000000589; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G-protein coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|SAAS:SAAS00521172};
KW Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW G-protein coupled receptor {ECO:0000256|SAAS:SAAS00529918};
KW Membrane {ECO:0000256|SAAS:SAAS00520911,
KW ECO:0000256|SAAS:SAAS00521172, ECO:0000256|SAM:Phobius};
KW Olfaction {ECO:0000256|SAAS:SAAS00521184};
KW Receptor {ECO:0000256|SAAS:SAAS00529918};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Sensory transduction {ECO:0000256|SAAS:SAAS00521184};
KW Transducer {ECO:0000256|SAAS:SAAS00529918};
KW Transmembrane {ECO:0000256|SAAS:SAAS00520911,
KW ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAAS:SAAS00520911,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 28 49 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 61 79 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 99 121 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 141 165 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 185 205 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 212 231 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 243 263 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 270 291 Helical. {ECO:0000256|SAM:Phobius}.
FT DOMAIN 42 291 G_PROTEIN_RECEP_F1_2.
FT {ECO:0000259|PROSITE:PS50262}.
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CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 42 291 iprf:G_PROTEIN_RECEP_F1_2 [T]
SQ SEQUENCE 315 AA; 35197 MW; DD4D51471E750A09 CRC64;
MQHQVNQSTG VVFVFVGFSE YPNLQVPLFL IFLIIYTITV LENLGMILVI RINAKLHTPM
YFFLSHLSIV DLCYTTVIAP KLLDLLITED RSMSLKGCII QFYFGCACVV TQNFMLAVMA
YDRFVAICNP LLYTVAMSQK LCALLVTGTY LWGGLCATTL TYFLLALSYC RSSIINHFCC
EYSAIISAAC SDSSISQIAC LLICMFNEIC SLLIIIVSYV VIFTTVIKIP TKGALQKALS
TCAPHLTAIS FCHGIILLLY CVLKSKSSLL LVKIVTVFYS MVIPMLNPLI YSLRNKDVKE
TVRKLIHMKI LSQSL
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