ID Q8TDQ4_HUMAN Unreviewed; 175 AA.
AC Q8TDQ4;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 10-MAY-2017, entry version 63.
DE SubName: Full=Putative uncharacterized protein {ECO:0000313|EMBL:AAL99388.1};
DE SubName: Full=Transmembrane protein 222 {ECO:0000313|Ensembl:ENSP00000476439};
GN Name=TMEM222 {ECO:0000313|Ensembl:ENSP00000476439};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAL99388.1};
RN [1] {ECO:0000313|EMBL:AAL99388.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang W., Wan T., Li N., Cao X.;
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSP00000476439}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA Waterston R.H., Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2
RT and 4.";
RL Nature 434:724-731(2005).
RN [3] {ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA Porter K.M., Prigmore E.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4] {ECO:0000213|PubMed:22814378}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [5] {ECO:0000313|Ensembl:ENSP00000476439}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (DEC-2013) to UniProtKB.
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DR EMBL; FO393419; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF251699; AAL99388.1; -; mRNA.
DR UniGene; Hs.469171; -.
DR STRING; 9606.ENSP00000363189; -.
DR Ensembl; ENST00000608611; ENSP00000476439; ENSG00000186501.
DR UCSC; uc057dup.1; human.
DR HGNC; HGNC:25363; TMEM222.
DR eggNOG; KOG3150; Eukaryota.
DR eggNOG; ENOG4111G1S; LUCA.
DR GeneTree; ENSGT00390000007371; -.
DR HOVERGEN; HBG055708; -.
DR ChiTaRS; TMEM222; human.
DR Proteomes; UP000005640; Chromosome 1.
DR Bgee; ENSG00000186501; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR008496; DUF778.
DR PANTHER; PTHR20921; PTHR20921; 1.
DR Pfam; PF05608; DUF778; 2.
PE 1: Evidence at protein level;
KW Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0000213|EPD:Q8TDQ4,
KW ECO:0000213|MaxQB:Q8TDQ4, ECO:0000213|PeptideAtlas:Q8TDQ4};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 154 174 Helical. {ECO:0000256|SAM:Phobius}.
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CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 28 78 ipfam:DUF778 [T]
FT MYHIT 86 145 ipfam:DUF778 [T]
SQ SEQUENCE 175 AA; 19862 MW; C0277CFEB4872D76 CRC64;
MKQYQGSGGV AMDVERSRFP YCVVWTPIPV LTWFFPIIGH MGICTSTGVI RDFAGPYFVS
EDNMAFGKPA KYWKLDPAQV YASGPNAWDT AVHDASEEYK HRMHNLCCDN CHSHVALALN
LMRYNNSTNW NMVTLCFFCL LYGKYVSVGA FVKTWLPFIL LLGIILTVSL VFNLR
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