ID Q8R269_MOUSE Unreviewed; 308 AA.
AC Q8R269;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 10-MAY-2017, entry version 104.
DE SubName: Full=MCG142227 {ECO:0000313|EMBL:EDL32580.1};
DE SubName: Full=Vomeronasal 1 receptor 222 {ECO:0000313|Ensembl:ENSMUSP00000076365};
DE SubName: Full=Vomeronasal 1 receptor, H16 {ECO:0000313|EMBL:AAI20859.1};
DE SubName: Full=Vomeronasal receptor V1RH16 {ECO:0000313|EMBL:AAL47946.1};
GN Name=Vmn1r222 {ECO:0000313|Ensembl:ENSMUSP00000076365,
GN ECO:0000313|MGI:MGI:2159679};
GN Synonyms=V1rh16 {ECO:0000313|EMBL:AAL47946.1};
GN ORFNames=mCG_142227 {ECO:0000313|EMBL:EDL32580.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000313|EMBL:AAL47946.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=129X1/SvJ {ECO:0000313|EMBL:AAL47946.1};
RA Rodriguez I., Mombaerts P.;
RL Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAL47946.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=129X1/SvJ {ECO:0000313|EMBL:AAL47946.1};
RA Adams M.;
RL Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AAL47946.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=129X1/SvJ {ECO:0000313|EMBL:AAL47946.1};
RX PubMed=11802169; DOI=10.1038/nn795;
RA Rodriguez I., Del Punta K., Rothman A., Ishii T., Mombaerts P.;
RT "Multiple new and isolated families within the mouse superfamily of
RT V1r vomeronasal receptors.";
RL Nat. Neurosci. 5:134-140(2002).
RN [4] {ECO:0000313|EMBL:EDL32580.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Mixed {ECO:0000313|EMBL:EDL32580.1};
RX PubMed=12040188; DOI=10.1126/science.1069193;
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R.,
RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A.,
RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.,
RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K.,
RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J.,
RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R.,
RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H.,
RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A.,
RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A.,
RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C.,
RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C.,
RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B.,
RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E.,
RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R.,
RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C.,
RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L.,
RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S.,
RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L.,
RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R.,
RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R.,
RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J.,
RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L.,
RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C.,
RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A.,
RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H.,
RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L.,
RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M.,
RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K.,
RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S.,
RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J.,
RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G.,
RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.;
RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and
RT the human genome.";
RL Science 296:1661-1671(2002).
RN [5] {ECO:0000313|EMBL:AAI20859.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000313|EMBL:AAI20859.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
RA Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6] {ECO:0000313|EMBL:EDL32580.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Mixed {ECO:0000313|EMBL:EDL32580.1};
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|Ensembl:ENSMUSP00000076365, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000076365,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of
RT the mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [8] {ECO:0000313|Ensembl:ENSMUSP00000076365}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000076365};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
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DR EMBL; AL669819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC120858; AAI20859.1; -; mRNA.
DR EMBL; BC120860; AAI20861.1; -; mRNA.
DR EMBL; AY065541; AAL47946.1; -; Genomic_DNA.
DR EMBL; CH466561; EDL32580.1; -; Genomic_DNA.
DR RefSeq; NP_599001.1; NM_134240.1.
DR UniGene; Mm.377226; -.
DR Ensembl; ENSMUST00000077116; ENSMUSP00000076365; ENSMUSG00000061022.
DR GeneID; 171274; -.
DR KEGG; mmu:171274; -.
DR UCSC; uc007ptl.1; mouse.
DR CTD; 171274; -.
DR MGI; MGI:2159679; Vmn1r222.
DR eggNOG; ENOG410IKIB; Eukaryota.
DR eggNOG; ENOG4111F74; LUCA.
DR GeneTree; ENSGT00840000129802; -.
DR HOGENOM; HOG000231675; -.
DR HOVERGEN; HBG107138; -.
DR KO; K04614; -.
DR OMA; LNISHFR; -.
DR OrthoDB; EOG09070AZD; -.
DR Proteomes; UP000000589; Chromosome 13.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:MGI.
DR GO; GO:0005550; F:pheromone binding; ISS:MGI.
DR GO; GO:0016503; F:pheromone receptor activity; ISS:MGI.
DR GO; GO:0019236; P:response to pheromone; ISS:MGI.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IBA:GO_Central.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:AAL47946.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12 31 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43 62 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 92 111 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 123 146 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 188 206 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 227 246 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 266 285 Helical. {ECO:0000256|SAM:Phobius}.
FT DOMAIN 21 284 G_PROTEIN_RECEP_F1_2.
FT {ECO:0000259|PROSITE:PS50262}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 21 284 iprf:G_PROTEIN_RECEP_F1_2 [T]
FT MYHIT 33 295 ipfam:V1R [T]
SQ SEQUENCE 308 AA; 35650 MW; D4BB7D3EF3DB2543 CRC64;
MVLQFIKETF FFFMTMIGTL GNISVSVDYF FRLLEGVKKK PIHLILIHLA FTNILILLTK
GFRKTVAAFG LRNFLDDIGC KSIVYLERVA RGLSICTSSL LTVVQAIIIS PRASGWRRLR
PKYAWHILPF LSFFWVLNGL ISVNLIHSTT NTRLNISHFR GDESNCYFML PSQKIKWIFL
PLMVLRDAVF QGAMGGASGY MVFLLYKHHQ HVLYLQNSKL LYRTPPELRA AQSVLLLMLC
FVFFYWTDCV FSFFLSLSLE EYSLMVNIHE FLTLGYAIFS PFVLIHRDGL LTEQWETLKQ
CVSHLSDQ
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