ID Q8CB76_MOUSE Unreviewed; 518 AA.
AC Q8CB76;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 10-MAY-2017, entry version 143.
DE SubName: Full=Putative uncharacterized protein {ECO:0000313|EMBL:BAC29499.1};
DE SubName: Full=Zinc finger protein 449 {ECO:0000313|EMBL:AAH82594.1, ECO:0000313|Ensembl:ENSMUSP00000099096};
GN Name=Zfp449 {ECO:0000313|EMBL:AAH82594.1,
GN ECO:0000313|Ensembl:ENSMUSP00000099096, ECO:0000313|MGI:MGI:1925869};
GN ORFNames=mCG_13631 {ECO:0000313|EMBL:EDL42142.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000313|EMBL:BAC29499.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC29499.1};
RC TISSUE=Bone {ECO:0000313|EMBL:BAC29499.1};
RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA Carninci P., Hayashizaki Y.;
RT "High-efficiency full-length cDNA cloning.";
RL Methods Enzymol. 303:19-44(1999).
RN [2] {ECO:0000313|EMBL:BAC29499.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC29499.1};
RC TISSUE=Bone {ECO:0000313|EMBL:BAC29499.1};
RX PubMed=11042159; DOI=10.1101/gr.145100;
RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT "Normalization and subtraction of cap-trapper-selected cDNAs to
RT prepare full-length cDNA libraries for rapid discovery of new genes.";
RL Genome Res. 10:1617-1630(2000).
RN [3] {ECO:0000313|EMBL:BAC29499.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC29499.1};
RC TISSUE=Bone {ECO:0000313|EMBL:BAC29499.1};
RX PubMed=11076861; DOI=10.1101/gr.152600;
RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M.,
RA Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A.,
RA Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K.,
RA Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M.,
RA Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J.,
RA Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT "RIKEN integrated sequence analysis (RISA) system--384-format
RT sequencing pipeline with 384 multicapillary sequencer.";
RL Genome Res. 10:1757-1771(2000).
RN [4] {ECO:0000313|EMBL:BAC29499.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC29499.1};
RC TISSUE=Bone {ECO:0000313|EMBL:BAC29499.1};
RX PubMed=11217851; DOI=10.1038/35055500;
RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT "Functional annotation of a full-length mouse cDNA collection.";
RL Nature 409:685-690(2001).
RN [5] {ECO:0000313|EMBL:BAC29499.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC29499.1};
RC TISSUE=Bone {ECO:0000313|EMBL:BAC29499.1};
RA Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P.,
RA Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W.,
RA Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T.,
RA Hori F., Imotani K., Ishii Y., Itoh M., Kagawa I., Kasukawa T.,
RA Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S.,
RA Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M.,
RA Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y.,
RA Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H.,
RA Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M.,
RA Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T.,
RA Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.;
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:BAC29499.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC29499.1};
RC TISSUE=Bone {ECO:0000313|EMBL:BAC29499.1};
RX PubMed=12466851; DOI=10.1038/nature01266;
RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT "Analysis of the mouse transcriptome based on functional annotation of
RT 60,770 full-length cDNAs.";
RL Nature 420:563-573(2002).
RN [7] {ECO:0000313|EMBL:EDL42142.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Mixed {ECO:0000313|EMBL:EDL42142.1};
RX PubMed=12040188; DOI=10.1126/science.1069193;
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R.,
RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A.,
RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.,
RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K.,
RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J.,
RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R.,
RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H.,
RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A.,
RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A.,
RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C.,
RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C.,
RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B.,
RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E.,
RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R.,
RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C.,
RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L.,
RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S.,
RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L.,
RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R.,
RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R.,
RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J.,
RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L.,
RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C.,
RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A.,
RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H.,
RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L.,
RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M.,
RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K.,
RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S.,
RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J.,
RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G.,
RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.;
RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and
RT the human genome.";
RL Science 296:1661-1671(2002).
RN [8] {ECO:0000313|EMBL:AAH82594.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAH82594.1};
RC TISSUE=Brain {ECO:0000313|EMBL:AAI45937.1}, and
RC Head {ECO:0000313|EMBL:AAH82594.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
RA Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9] {ECO:0000313|EMBL:BAC29499.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC29499.1};
RC TISSUE=Bone {ECO:0000313|EMBL:BAC29499.1};
RG The FANTOM Consortium;
RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT "The Transcriptional Landscape of the Mammalian Genome.";
RL Science 309:1559-1563(2005).
RN [10] {ECO:0000313|EMBL:BAC29499.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC29499.1};
RC TISSUE=Bone {ECO:0000313|EMBL:BAC29499.1};
RX PubMed=16141073; DOI=10.1126/science.1112009;
RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT "Antisense Transcription in the Mammalian Transcriptome.";
RL Science 309:1564-1566(2005).
RN [11] {ECO:0000313|EMBL:EDL42142.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Mixed {ECO:0000313|EMBL:EDL42142.1};
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [12] {ECO:0000313|Ensembl:ENSMUSP00000099096, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000099096,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of
RT the mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [13] {ECO:0000213|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and
RT expression.";
RL Cell 143:1174-1189(2010).
RN [14] {ECO:0000313|Ensembl:ENSMUSP00000099096}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000099096};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-
CC ProRule:PRU00187, ECO:0000256|SAAS:SAAS00772597}.
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DR EMBL; AL683799; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR954970; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR955029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC082594; AAH82594.1; -; mRNA.
DR EMBL; BC145936; AAI45937.1; -; mRNA.
DR EMBL; BC145938; AAI45939.1; -; mRNA.
DR EMBL; AK036596; BAC29499.1; -; mRNA.
DR EMBL; CH466583; EDL42142.1; -; Genomic_DNA.
DR RefSeq; NP_084415.1; NM_030139.4.
DR UniGene; Mm.207345; -.
DR STRING; 10090.ENSMUSP00000099096; -.
DR Ensembl; ENSMUST00000101560; ENSMUSP00000099096; ENSMUSG00000073176.
DR GeneID; 78619; -.
DR KEGG; mmu:78619; -.
DR UCSC; uc009tgb.2; mouse.
DR CTD; 78619; -.
DR MGI; MGI:1925869; Zfp449.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00730000110971; -.
DR HOGENOM; HOG000234619; -.
DR HOVERGEN; HBG018163; -.
DR KO; K09230; -.
DR OMA; PVAEAWI; -.
DR OrthoDB; EOG091G02KC; -.
DR TreeFam; TF336949; -.
DR Proteomes; UP000000589; Chromosome X.
DR Bgee; ENSMUSG00000073176; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR008916; Retrov_capsid_C.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF02023; SCAN; 1.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF47353; SSF47353; 1.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 1: Evidence at protein level;
KW Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW Metal-binding {ECO:0000256|SAAS:SAAS00772615};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187,
KW ECO:0000256|SAAS:SAAS00772585};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|SAAS:SAAS00772661};
KW Transcription {ECO:0000256|SAAS:SAAS00772592};
KW Transcription regulation {ECO:0000256|SAAS:SAAS00772592};
KW Zinc {ECO:0000256|SAAS:SAAS00772615};
KW Zinc-finger {ECO:0000256|SAAS:SAAS00772615}.
FT DOMAIN 30 112 SCAN box. {ECO:0000259|PROSITE:PS50804}.
FT DOMAIN 323 350 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 351 378 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 379 406 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 407 434 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 435 462 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 463 490 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 491 513 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 493 513 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 379 401 ismart:ZnF_C2H2 [T]
FT MYHIT 379 406 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 437 457 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 407 434 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 325 345 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 323 345 ismart:ZnF_C2H2 [T]
FT MYHIT 435 462 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 463 485 ismart:ZnF_C2H2 [T]
FT MYHIT 323 350 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 353 373 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 351 373 ismart:ZnF_C2H2 [T]
FT MYHIT 491 513 ismart:ZnF_C2H2 [T]
FT MYHIT 435 457 ismart:ZnF_C2H2 [T]
FT MYHIT 27 113 ipfam:SCAN [T]
FT MYHIT 409 429 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 407 429 ismart:ZnF_C2H2 [T]
FT MYHIT 26 134 ismart:SCAN [T]
FT MYHIT 491 513 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 463 490 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 465 485 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 351 378 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 381 401 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 30 112 iprf:SCAN_BOX [T]
SQ SEQUENCE 518 AA; 59885 MW; 90979DAE159A5749 CRC64;
MAVALGCAIQ ASLNQGSVLQ EYDTDCEVFR QRFRQFQYTE AAGPHEAFNK LWELCCQWLK
PKMRSKEQIL ELLVLEQFLT ILPTEIETWV REHCPDNRER VVSLIEDLQR ELEIPEPQID
MDDMLLEELA PVGTVPMPPN LHLEEPSLQV MEPVQEPPVP DAWIPQAGPQ DLNYSADAEC
QSFLDPGYQL PKLDMNFPLD HREEPWVKDL EDPKEMKQLL DSKIGFEMGI ENEEDTSKEK
KLETLYPFVV TLEGNALHGP ILQKDYVQLE NQWETSPEDL QTDLTKLVDP QNPTLGETPE
SPSLEEPLTP KPPKKKSPGD KPHRCPQCGK CFARKSQLTG HQRIHSGEEP HKCPECGKRF
LRSSDLYRHQ RLHTGERPYE CTVCKKRFTR RSHLLGHQRT HSEEETYKCL ECGKTFCHGS
SLKRHLKTHT GEKPHRCPNC GKSFSRLTAL TLHQRTHTEE RPFKCSYCGK SFRQRPSLVI
HLRIHTGEKP YKCTHCSKSF RQRAGLIMHQ VTHFRGLL
//
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