ID Q7ZUU6_DANRE Unreviewed; 178 AA.
AC Q7ZUU6; F1Q766;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 10-MAY-2017, entry version 100.
DE SubName: Full=Creatine kinase, mitochondrial 2a (sarcomeric) {ECO:0000313|Ensembl:ENSDARP00000092223};
DE SubName: Full=Zgc:56085 {ECO:0000313|EMBL:AAH47826.1};
DE SubName: Full=Zgc:56085 protein {ECO:0000313|EMBL:AAI64873.1};
GN Name=ckmt2a {ECO:0000313|Ensembl:ENSDARP00000092223,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-5717};
GN ORFNames=zgc:56085 {ECO:0000313|EMBL:AAH47826.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH47826.1};
RN [1] {ECO:0000313|EMBL:AAH47826.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Whole body {ECO:0000313|EMBL:AAH47826.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAI64873.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=PCR rescue {ECO:0000313|EMBL:AAI64873.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSDARP00000092223}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000092223};
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [4] {ECO:0000313|Ensembl:ENSDARP00000092223, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000092223,
RC ECO:0000313|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S.,
RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the
RT human genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|Ensembl:ENSDARP00000134106}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000134106};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ATP:guanido phosphotransferase family.
CC {ECO:0000256|PROSITE-ProRule:PRU00843,
CC ECO:0000256|RuleBase:RU000505}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00843}.
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DR EMBL; CU571089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC047826; AAH47826.1; -; mRNA.
DR EMBL; BC164873; AAI64873.1; -; mRNA.
DR UniGene; Dr.11252; -.
DR STRING; 7955.ENSDARP00000092223; -.
DR Ensembl; ENSDART00000101449; ENSDARP00000092223; ENSDARG00000069615.
DR Ensembl; ENSDART00000168670; ENSDARP00000134106; ENSDARG00000069615.
DR ZFIN; ZDB-GENE-030131-5717; ckmt2a.
DR eggNOG; KOG3581; Eukaryota.
DR eggNOG; COG3869; LUCA.
DR GeneTree; ENSGT00550000074561; -.
DR HOGENOM; HOG000232165; -.
DR HOVERGEN; HBG066955; -.
DR InParanoid; F1Q766; -.
DR OMA; XSPLLLA; -.
DR OrthoDB; EOG091G0HZ0; -.
DR TreeFam; TF314214; -.
DR Reactome; R-DRE-71288; Creatine metabolism.
DR Proteomes; UP000000437; Chromosome 10.
DR Bgee; ENSDARG00000069615; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.590.10; -; 1.
DR InterPro; IPR000749; ATP-guanido_PTrfase.
DR InterPro; IPR022415; ATP-guanido_PTrfase_AS.
DR InterPro; IPR022414; ATP-guanido_PTrfase_cat.
DR InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR PANTHER; PTHR11547; PTHR11547; 1.
DR Pfam; PF00217; ATP-gua_Ptrans; 1.
DR PROSITE; PS00112; PHOSPHAGEN_KINASE; 1.
DR PROSITE; PS51510; PHOSPHAGEN_KINASE_C; 1.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00843};
KW Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW Kinase {ECO:0000256|PROSITE-ProRule:PRU00843,
KW ECO:0000256|RuleBase:RU000505};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00843};
KW Proteomics identification {ECO:0000213|PeptideAtlas:Q7ZUU6};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transferase {ECO:0000256|PROSITE-ProRule:PRU00843,
KW ECO:0000256|RuleBase:RU000505}.
FT DOMAIN 1 161 Phosphagen kinase C-terminal.
FT {ECO:0000259|PROSITE:PS51510}.
FT NP_BIND 86 90 ATP. {ECO:0000256|PROSITE-
FT ProRule:PRU00843}.
FT NP_BIND 114 119 ATP. {ECO:0000256|PROSITE-
FT ProRule:PRU00843}.
FT BINDING 30 30 ATP. {ECO:0000256|PROSITE-
FT ProRule:PRU00843}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 1 161 iprf:PHOSPHAGEN_KINASE_C [T]
FT MYHIT 77 83 ipat:PHOSPHAGEN_KINASE [T]
FT MYHIT 1 160 ipfam:ATP-gua_Ptrans [T]
SQ SEQUENCE 178 AA; 20488 MW; F749873AB3C9759C CRC64;
MARDWPDARG IWHNNEKTFL IWVNEEDHTR VISMEKGGNM KRVFERFCRG LKQVEHLIQE
RGWEFMWNER LGYVLTCPSN LGTGLRAGVH VRLPKLSKDP RFGKILDNLR LQKRGTGGVD
TAAVGDTFDI SNLDRLGKSE VELVQLVVDG VNYLIECEKR LEKGQDIKVP APLQQFKK
//
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