Entry euk:Q7ZUK1_DANRE

ID   Q7ZUK1_DANRE            Unreviewed;       147 AA.
AC   Q7ZUK1; F1R981;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   10-MAY-2017, entry version 115.
DE   SubName: Full=Ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) {ECO:0000313|Ensembl:ENSDARP00000063836};
DE   SubName: Full=Zgc:55886 {ECO:0000313|EMBL:AAH65678.1};
DE   SubName: Full=Zgc:55886 protein {ECO:0000313|EMBL:AAH48896.1};
GN   Name=ube2d2 {ECO:0000313|Ensembl:ENSDARP00000063836,
GN   ECO:0000313|ZFIN:ZDB-GENE-120312-1};
GN   Synonyms=ube2d2l {ECO:0000313|ZFIN:ZDB-GENE-120312-1},
GN   zgc:55886 {ECO:0000313|EMBL:AAH48896.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH48896.1};
RN   [1] {ECO:0000313|EMBL:AAH48896.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB {ECO:0000313|EMBL:AAH48896.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:AAH48896.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAH65678.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney {ECO:0000313|EMBL:AAH65678.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:AAI64949.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=PCR rescue {ECO:0000313|EMBL:AAI64949.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Ensembl:ENSDARP00000063836}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000063836};
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
RN   [5] {ECO:0000313|Ensembl:ENSDARP00000063836, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000063836,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
CC       {ECO:0000256|PROSITE-ProRule:PRU00388,
CC       ECO:0000256|RuleBase:RU362109, ECO:0000256|SAAS:SAAS00805669}.
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DR   EMBL; CABZ01014055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU469522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU570692; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC048896; AAH48896.1; -; mRNA.
DR   EMBL; BC065678; AAH65678.1; -; mRNA.
DR   EMBL; BC164949; AAI64949.1; -; mRNA.
DR   RefSeq; NP_957253.1; NM_200959.2.
DR   UniGene; Dr.75179; -.
DR   STRING; 7955.ENSDARP00000049284; -.
DR   STRING; 7955.ENSDARP00000063836; -.
DR   Ensembl; ENSDART00000063837; ENSDARP00000063836; ENSDARG00000043484.
DR   GeneID; 393934; -.
DR   KEGG; dre:393934; -.
DR   CTD; 7322; -.
DR   ZFIN; ZDB-GENE-120312-1; ube2d2.
DR   eggNOG; KOG0417; Eukaryota.
DR   eggNOG; COG5078; LUCA.
DR   GeneTree; ENSGT00760000119012; -.
DR   HOVERGEN; HBG063308; -.
DR   InParanoid; F1R981; -.
DR   KO; K06689; -.
DR   OMA; YAGGVYF; -.
DR   OrthoDB; EOG091G0GF8; -.
DR   TreeFam; TF101108; -.
DR   Reactome; R-DRE-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
DR   Reactome; R-DRE-202424; Downstream TCR signaling.
DR   Reactome; R-DRE-2871837; FCERI mediated NF-kB activation.
DR   Reactome; R-DRE-5607764; CLEC7A (Dectin-1) signaling.
DR   Reactome; R-DRE-8866652; Synthesis of active ubiquitin: roles of E1 and E2 enzymes.
DR   Reactome; R-DRE-8866654; E3 ubiquitin ligases ubiquitinate target proteins.
DR   Proteomes; UP000000437; Chromosome 14.
DR   Bgee; ENSDARG00000043484; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   CDD; cd00195; UBCc; 1.
DR   Gene3D; 3.10.110.10; -; 1.
DR   InterPro; IPR000608; UBQ-conjugat_E2.
DR   InterPro; IPR023313; UBQ-conjugating_AS.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   Pfam; PF00179; UQ_con; 1.
DR   SUPFAM; SSF54495; SSF54495; 1.
DR   PROSITE; PS00183; UBIQUITIN_CONJUGAT_1; 1.
DR   PROSITE; PS50127; UBIQUITIN_CONJUGAT_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding {ECO:0000256|RuleBase:RU362109};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362109};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Ubl conjugation pathway {ECO:0000256|RuleBase:RU362109,
KW   ECO:0000256|SAAS:SAAS00805691}.
FT   DOMAIN        4    136       UBIQUITIN_CONJUGAT_2.
FT                                {ECO:0000259|PROSITE:PS50127}.
FT   ACT_SITE     85     85       Glycyl thioester intermediate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00388}.
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CC   The following FT lines are automated annotations from the MyHits database.
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FT   MYHIT         5    141       ipfam:UQ_con [T]
FT   MYHIT        74     89       ipat:UBIQUITIN_CONJUGAT_1 [T]
FT   MYHIT         4    136       iprf:UBIQUITIN_CONJUGAT_2 [T]
SQ   SEQUENCE   147 AA;  16744 MW;  240799E1CDC9FACE CRC64;
     MALKRIHKEL HDLGRDPPAQ CSAGPVGDDM FHWQATIMGP NDSPYQGGVF FLTIHFPTDY
     PFKPPKVAFT TRIYHPNINS NGSICLDILR SQWSPALTIS KVLLSICSLL CDPNPDDPLV
     PEIARIYKTD REKYNRIARE WTQKYAM
//