Entry euk:Q7TRT9_MOUSE

ID   Q7TRT9_MOUSE            Unreviewed;       305 AA.
AC   Q7TRT9; F7AB21;
DT   01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2003, sequence version 1.
DT   10-MAY-2017, entry version 111.
DE   SubName: Full=Olfactory receptor 527 {ECO:0000313|EMBL:AAI47214.1, ECO:0000313|Ensembl:ENSMUSP00000129414};
DE   SubName: Full=Olfactory receptor Olfr527 {ECO:0000313|EMBL:AAP71022.1};
GN   Name=Olfr527 {ECO:0000313|EMBL:AAP71022.1,
GN   ECO:0000313|Ensembl:ENSMUSP00000129414, ECO:0000313|MGI:MGI:3030361};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000313|EMBL:AAP71022.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA   Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA   Walker M., Williams E.M., Trask B.J.;
RT   "Odorant receptor expressed sequence tags demonstrate olfactory
RT   expression of over 400 genes, extensive alternate splicing and unequal
RT   expression levels.";
RL   Genome Biol. 4:R71.1-R71.13(2003).
RN   [2] {ECO:0000313|EMBL:AAP71022.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Sanders K.;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:AAI47214.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000313|EMBL:AAI47214.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
RA   Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
RA   Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
RA   Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
RA   Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
RA   Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
RA   Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
RA   Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
RA   Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
RA   Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
RA   Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
RA   Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
RA   Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
RA   Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
RA   Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
RA   Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
RA   Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
RA   Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
RA   Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000129414, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000129414,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [5] {ECO:0000313|Ensembl:ENSMUSP00000129414}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000129414};
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
RN   [6] {ECO:0000313|Ensembl:ENSMUSP00000148971}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000148971};
RG   Ensembl;
RL   Submitted (DEC-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|SAAS:SAAS00521146}; Multi-pass membrane protein
CC       {ECO:0000256|SAAS:SAAS00521146}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000256|SAAS:SAAS00591716}.
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DR   EMBL; AC107839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC147213; AAI47214.1; -; mRNA.
DR   EMBL; BC147214; AAI47215.1; -; mRNA.
DR   EMBL; AY317635; AAP71022.1; -; Genomic_DNA.
DR   RefSeq; NP_001011776.1; NM_001011776.1.
DR   UniGene; Mm.377310; -.
DR   STRING; 10090.ENSMUSP00000129414; -.
DR   Ensembl; ENSMUST00000172230; ENSMUSP00000129414; ENSMUSG00000062782.
DR   Ensembl; ENSMUST00000214143; ENSMUSP00000148971; ENSMUSG00000062782.
DR   Ensembl; ENSMUST00000214858; ENSMUSP00000149080; ENSMUSG00000062782.
DR   GeneID; 257939; -.
DR   KEGG; mmu:257939; -.
DR   UCSC; uc009khn.1; mouse.
DR   CTD; 257939; -.
DR   MGI; MGI:3030361; Olfr527.
DR   eggNOG; ENOG410IKYT; Eukaryota.
DR   eggNOG; ENOG410YX9S; LUCA.
DR   GeneTree; ENSGT00440000034500; -.
DR   HOGENOM; HOG000041364; -.
DR   HOVERGEN; HBG017625; -.
DR   KO; K04257; -.
DR   OMA; CPLHYSA; -.
DR   OrthoDB; EOG091G0AZH; -.
DR   TreeFam; TF340208; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0050907; P:detection of chemical stimulus involved in sensory perception; IBA:GO_Central.
DR   GO; GO:0007186; P:G-protein coupled receptor signaling pathway; ISA:MGI.
DR   GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane {ECO:0000256|SAAS:SAAS00521172};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   G-protein coupled receptor {ECO:0000256|SAAS:SAAS00529918};
KW   Membrane {ECO:0000256|SAAS:SAAS00520911,
KW   ECO:0000256|SAAS:SAAS00521172, ECO:0000256|SAM:Phobius};
KW   Olfaction {ECO:0000256|SAAS:SAAS00521184};
KW   Receptor {ECO:0000256|SAAS:SAAS00529918};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Sensory transduction {ECO:0000256|SAAS:SAAS00521184};
KW   Transducer {ECO:0000256|SAAS:SAAS00529918};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00520911,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00520911,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     25     45       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     57     76       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     96    117       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    137    155       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    201    223       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    235    257       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    269    289       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       39    287       G_PROTEIN_RECEP_F1_2.
FT                                {ECO:0000259|PROSITE:PS50262}.
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CC   The following FT lines are automated annotations from the MyHits database.
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FT   MYHIT        39    287       iprf:G_PROTEIN_RECEP_F1_2 [T]
SQ   SEQUENCE   305 AA;  33794 MW;  BFB76B14F50C5711 CRC64;
     MMNGTLVTEF LILGFSEMPH LRVPLLFSFL CLYMAAISGN LLIMVTISAS PALHTPMYFF
     LVNLAIVDIL CTSTILPKLL DSMMTGRTIS YGGCMAQLFF FTWSLGAELL LFSAMAYDRF
     VAICCPLHYS AWMGPRVCAF LAGIVWTISL TNTSVHTGLM LRLPFCSSNV IEHFFCEIPP
     LLKLSCAPTQ LNEAMAFAAD VFLAVGNFSV TILSYGFIVA SILKIRSAEG KRRAFSTCSA
     HLIVVTMYYS TVIYTYIRPS SSYSLNKDKV VSIIYTSVAP TLNPLIYTLR NKDVKVALRR
     LLSCC
//