Entry euk:Q6PEJ2_DANRE

ID   Q6PEJ2_DANRE            Unreviewed;       142 AA.
AC   Q6PEJ2;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   10-MAY-2017, entry version 101.
DE   SubName: Full=Adaptor-related protein complex 2, sigma 1 subunit {ECO:0000313|Ensembl:ENSDARP00000031559};
DE   SubName: Full=Zgc:65827 {ECO:0000313|EMBL:AAH58042.1};
GN   Name=ap2s1 {ECO:0000313|Ensembl:ENSDARP00000031559,
GN   ECO:0000313|ZFIN:ZDB-GENE-040426-2174};
GN   Synonyms=zgc:65827 {ECO:0000313|EMBL:AAH58042.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH58042.1};
RN   [1] {ECO:0000313|EMBL:AAH58042.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney {ECO:0000313|EMBL:AAH58042.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000031559}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000031559};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000031559, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000031559,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
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DR   EMBL; CR293508; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC058042; AAH58042.1; -; mRNA.
DR   RefSeq; NP_998320.1; NM_213155.2.
DR   UniGene; Dr.76864; -.
DR   STRING; 7955.ENSDARP00000031559; -.
DR   Ensembl; ENSDART00000033871; ENSDARP00000031559; ENSDARG00000026967.
DR   GeneID; 100148085; -.
DR   KEGG; dre:100148085; -.
DR   CTD; 1175; -.
DR   ZFIN; ZDB-GENE-040426-2174; ap2s1.
DR   eggNOG; KOG0935; Eukaryota.
DR   eggNOG; COG5030; LUCA.
DR   GeneTree; ENSGT00530000062839; -.
DR   HOGENOM; HOG000185227; -.
DR   HOVERGEN; HBG050517; -.
DR   KO; K11827; -.
DR   OMA; SFFDNVC; -.
DR   OrthoDB; EOG091G0QZV; -.
DR   TreeFam; TF300139; -.
DR   Reactome; R-DRE-171052; LDL-mediated lipid transport.
DR   Reactome; R-DRE-177504; Retrograde neurotrophin signalling.
DR   Reactome; R-DRE-2132295; MHC class II antigen presentation.
DR   Reactome; R-DRE-3928665; EPH-ephrin mediated repulsion of cells.
DR   Reactome; R-DRE-416993; Trafficking of GluR2-containing AMPA receptors.
DR   Reactome; R-DRE-437239; Recycling pathway of L1.
DR   Reactome; R-DRE-5099900; WNT5A-dependent internalization of FZD4.
DR   Reactome; R-DRE-5140745; WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
DR   Reactome; R-DRE-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   Reactome; R-DRE-8856828; Clathrin-mediated endocytosis.
DR   Reactome; R-DRE-8866427; VLDLR internalisation and degradation.
DR   Proteomes; UP000000437; Chromosome 15.
DR   Bgee; ENSDARG00000026967; -.
DR   GO; GO:0030122; C:AP-2 adaptor complex; IEA:InterPro.
DR   GO; GO:0008565; F:protein transporter activity; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR016635; AP_complex_ssu.
DR   InterPro; IPR022775; AP_mu_sigma_su.
DR   InterPro; IPR027156; APS2.
DR   InterPro; IPR000804; Clathrin_sm-chain_CS.
DR   InterPro; IPR011012; Longin-like_dom.
DR   PANTHER; PTHR11753; PTHR11753; 1.
DR   PANTHER; PTHR11753:SF21; PTHR11753:SF21; 1.
DR   Pfam; PF01217; Clat_adaptor_s; 1.
DR   PIRSF; PIRSF015588; AP_complex_sigma; 1.
DR   SUPFAM; SSF64356; SSF64356; 1.
DR   PROSITE; PS00989; CLAT_ADAPTOR_S; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Protein transport {ECO:0000256|SAAS:SAAS00017283};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:Q6PEJ2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transport {ECO:0000256|SAAS:SAAS00017283}.
FT   DOMAIN        1    141       Clat_adaptor_s.
FT                                {ECO:0000259|Pfam:PF01217}.
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CC   The following FT lines are automated annotations from the MyHits database.
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FT   MYHIT         1    141       ipfam:Clat_adaptor_s [T]
FT   MYHIT        57     67       ipat:CLAT_ADAPTOR_S [T]
SQ   SEQUENCE   142 AA;  17005 MW;  54CDD868D3AF0DE3 CRC64;
     MIRFILIQNR AGKTRLAKWY MQFDDDEKQK LIEEVHAVVT VRDAKHTNFV EFRNFKIIYR
     RYAGLYFCIC VDVTDNNLAY LEAIHNFVEV LNEYFHNVCE LDLVFNFYKV YTVVDEMFLA
     GEIRETSQTK VLKQLLMLQS LE
//