Entry euk:Q6PBX8_DANRE

ID   Q6PBX8_DANRE            Unreviewed;       244 AA.
AC   Q6PBX8;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   10-MAY-2017, entry version 102.
DE   SubName: Full=NADH dehydrogenase (ubiquinone) flavoprotein 2 {ECO:0000313|Ensembl:ENSDARP00000004700};
DE   SubName: Full=Zgc:73198 {ECO:0000313|EMBL:AAH59546.1};
GN   Name=ndufv2 {ECO:0000313|Ensembl:ENSDARP00000004700,
GN   ECO:0000313|ZFIN:ZDB-GENE-040426-1713};
GN   Synonyms=zgc:73198 {ECO:0000313|EMBL:AAH59546.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH59546.1};
RN   [1] {ECO:0000313|EMBL:AAH59546.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Wild-type {ECO:0000313|EMBL:AAH59546.1};
RC   TISSUE=Eye {ECO:0000313|EMBL:AAH59546.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000004700}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000004700};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000004700, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000004700,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
CC   -!- COFACTOR:
CC       Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000216-1};
CC       Note=Binds 1 [2Fe-2S] cluster. {ECO:0000256|PIRSR:PIRSR000216-1};
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DR   EMBL; CABZ01087851; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01087852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01087853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC059546; AAH59546.1; -; mRNA.
DR   RefSeq; NP_957041.1; NM_200747.1.
DR   UniGene; Dr.76085; -.
DR   STRING; 7955.ENSDARP00000004700; -.
DR   Ensembl; ENSDART00000027313; ENSDARP00000004700; ENSDARG00000013044.
DR   GeneID; 393720; -.
DR   KEGG; dre:393720; -.
DR   CTD; 4729; -.
DR   ZFIN; ZDB-GENE-040426-1713; ndufv2.
DR   eggNOG; KOG3196; Eukaryota.
DR   eggNOG; COG1905; LUCA.
DR   GeneTree; ENSGT00390000017580; -.
DR   HOGENOM; HOG000257748; -.
DR   HOVERGEN; HBG029601; -.
DR   KO; K03943; -.
DR   OMA; HKQAATI; -.
DR   OrthoDB; EOG091G0GRD; -.
DR   TreeFam; TF300004; -.
DR   Reactome; R-DRE-611105; Respiratory electron transport.
DR   Reactome; R-DRE-6799198; Complex I biogenesis.
DR   Proteomes; UP000000437; Chromosome 2.
DR   Bgee; ENSDARG00000013044; -.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IBA:GO_Central.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IBA:GO_Central.
DR   InterPro; IPR002023; NuoE-like.
DR   InterPro; IPR012336; Thioredoxin-like_fold.
DR   PANTHER; PTHR10371; PTHR10371; 1.
DR   PIRSF; PIRSF000216; NADH_DH_24kDa; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR01958; nuoE_fam; 1.
DR   PROSITE; PS01099; COMPLEX1_24K; 1.
PE   1: Evidence at protein level;
KW   2Fe-2S {ECO:0000256|PIRSR:PIRSR000216-1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Iron {ECO:0000256|PIRSR:PIRSR000216-1};
KW   Iron-sulfur {ECO:0000256|PIRSR:PIRSR000216-1};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000216-1};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:Q6PBX8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT   METAL       130    130       Iron-sulfur (2Fe-2S).
FT                                {ECO:0000256|PIRSR:PIRSR000216-1}.
FT   METAL       135    135       Iron-sulfur (2Fe-2S).
FT                                {ECO:0000256|PIRSR:PIRSR000216-1}.
FT   METAL       171    171       Iron-sulfur (2Fe-2S).
FT                                {ECO:0000256|PIRSR:PIRSR000216-1}.
FT   METAL       175    175       Iron-sulfur (2Fe-2S).
FT                                {ECO:0000256|PIRSR:PIRSR000216-1}.
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CC   The following FT lines are automated annotations from the MyHits database.
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FT   MYHIT       161    179       ipat:COMPLEX1_24K [T]
SQ   SEQUENCE   244 AA;  26595 MW;  18907414930F6CAB CRC64;
     MFLSSTLRSA VSYTARQVRS LHQTSARAGA GGIFVHRDTP ENNPDTPFEF TPENMKRVEA
     IINNYPEGHK AAATIPVLDL AQRQNGWLPI SAMNKVAEVL GIAPMRVYEV ATFYTMFLRQ
     PVGKYHIQIC TTTPCMLCDS DSILEAIQNK LGIKVGETTA DKLFTLTEVE CLGACVNAPM
     VQINDNYYED LKPSDMEQII DELKAGRVPP PGPRSGRFSC EPAGGLTSLT EPPPGPGVGV
     RADL
//