ID Q6P6Y4_DANRE Unreviewed; 502 AA.
AC Q6P6Y4;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 10-MAY-2017, entry version 87.
DE SubName: Full=RAB guanine nucleotide exchange factor (GEF) 1 {ECO:0000313|Ensembl:ENSDARP00000016779};
DE SubName: Full=Zgc:65944 {ECO:0000313|EMBL:AAH61953.1};
GN Name=rabgef1 {ECO:0000313|Ensembl:ENSDARP00000016779,
GN ECO:0000313|ZFIN:ZDB-GENE-040426-1486};
GN Synonyms=zgc:65944 {ECO:0000313|EMBL:AAH61953.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH61953.1};
RN [1] {ECO:0000313|EMBL:AAH61953.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney {ECO:0000313|EMBL:AAH61953.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000016779}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000016779};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSDARP00000016779, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000016779,
RC ECO:0000313|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S.,
RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the
RT human genome.";
RL Nature 496:498-503(2013).
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DR EMBL; AL935293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC061953; AAH61953.1; -; mRNA.
DR RefSeq; NP_957137.1; NM_200843.1.
DR UniGene; Dr.123825; -.
DR UniGene; Dr.9342; -.
DR STRING; 7955.ENSDARP00000112905; -.
DR Ensembl; ENSDART00000018977; ENSDARP00000016779; ENSDARG00000014430.
DR Ensembl; ENSDART00000138243; ENSDARP00000112905; ENSDARG00000014430.
DR GeneID; 393816; -.
DR KEGG; dre:393816; -.
DR CTD; 27342; -.
DR ZFIN; ZDB-GENE-040426-1486; rabgef1.
DR eggNOG; KOG2319; Eukaryota.
DR eggNOG; KOG3173; Eukaryota.
DR eggNOG; ENOG410YGAZ; LUCA.
DR GeneTree; ENSGT00530000063341; -.
DR HOGENOM; HOG000070180; -.
DR HOVERGEN; HBG062584; -.
DR KO; K20131; -.
DR OMA; WTDGIAR; -.
DR OrthoDB; EOG091G059N; -.
DR TreeFam; TF321331; -.
DR Reactome; R-DRE-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR Proteomes; UP000000437; Chromosome 10.
DR Bgee; ENSDARG00000014430; -.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR002653; Znf_A20.
DR Pfam; PF02204; VPS9; 1.
DR Pfam; PF01754; zf-A20; 1.
DR SMART; SM00167; VPS9; 1.
DR SMART; SM00259; ZnF_A20; 1.
DR PROSITE; PS51205; VPS9; 1.
DR PROSITE; PS51036; ZF_A20; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW Proteomics identification {ECO:0000213|PeptideAtlas:Q6P6Y4};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 13 47 A20-type. {ECO:0000259|PROSITE:PS51036}.
FT DOMAIN 242 385 VPS9. {ECO:0000259|PROSITE:PS51205}.
FT COILED 431 465 {ECO:0000256|SAM:Coils}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 280 380 ipfam:VPS9 [T]
FT MYHIT 16 40 ismart:ZnF_A20 [T]
FT MYHIT 13 47 iprf:ZF_A20 [T]
FT MYHIT 242 385 iprf:VPS9 [T]
FT MYHIT 17 40 ipfam:zf-A20 [T]
FT MYHIT 272 393 ismart:VPS9 [T]
SQ SEQUENCE 502 AA; 57410 MW; A918434F33306625 CRC64;
MSQRSERRGI HVDQSELLCK KGCGYYGNAA WQGLCSKCWR DEYQKARQRQ IQDDWALAEK
LQREEEAAYV SSHSSSQTQP PQSHSQHSLA TFSKFEEKKT NEKTRKVTTV KKFFSPSSRT
APKKESHEAK TPSPSITRQS SIETDRVSRD FVEFLKTLHK PGREIHKHSR AFIDSMGNKK
QDLSAEELSE CVQDFYQGMS DRLLNHFKGS SEKVDRVMDQ VEKYIMTRLY KSVFCPETSD
DEKKDLATQH RIRALHWVTI QMLCVPVEEE IPEVSDSVVK AITDIIEMDS KRVPRDKLAC
ITSCSKHIFN AIRVTKNEPA SADDFLPTLI YIVLKANPPR LQSNIQYITR FCNPSRLMTG
EDGYYFTNLC CAVAFIEKLD AQSLNLSPED FERYMSGQAS PRRQDDPAGW PQSGSRVNPV
LTQIQHNLSV LSSLEKRQQQ VIEGAQSLEA ELTEWQESVA REVQEILERY PLDIKPRASA
IDAENVENDR LPPPLQPQVF AG
//
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