ID Q66I18_DANRE Unreviewed; 656 AA.
AC Q66I18;
DT 11-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2004, sequence version 1.
DT 10-MAY-2017, entry version 110.
DE SubName: Full=Ring finger protein 103 {ECO:0000313|EMBL:AAH81585.1, ECO:0000313|Ensembl:ENSDARP00000138760};
GN Name=rnf103 {ECO:0000313|EMBL:AAH81585.1,
GN ECO:0000313|Ensembl:ENSDARP00000138760,
GN ECO:0000313|ZFIN:ZDB-GENE-040912-171};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH81585.1};
RN [1] {ECO:0000313|EMBL:AAH81585.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Whole {ECO:0000313|EMBL:AAH81585.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000138760, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000138760,
RC ECO:0000313|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S.,
RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the
RT human genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000138760}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000138760};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
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DR EMBL; AL929267; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC081585; AAH81585.1; -; mRNA.
DR RefSeq; NP_001004600.1; NM_001004600.1.
DR UniGene; Dr.81204; -.
DR STRING; 7955.ENSDARP00000074564; -.
DR Ensembl; ENSDART00000168462; ENSDARP00000138760; ENSDARG00000100850.
DR GeneID; 447861; -.
DR KEGG; dre:447861; -.
DR CTD; 7844; -.
DR ZFIN; ZDB-GENE-040912-171; rnf103.
DR eggNOG; KOG0800; Eukaryota.
DR eggNOG; ENOG41121N2; LUCA.
DR GeneTree; ENSGT00390000006413; -.
DR HOGENOM; HOG000006578; -.
DR HOVERGEN; HBG054144; -.
DR KO; K15695; -.
DR OMA; GKVHWEK; -.
DR OrthoDB; EOG091G0EZD; -.
DR TreeFam; TF329229; -.
DR Reactome; R-DRE-901032; ER Quality Control Compartment (ERQC).
DR Proteomes; UP000000437; Chromosome 14.
DR Bgee; ENSDARG00000057438; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00162; RING; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 327 345 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 354 379 Helical. {ECO:0000256|SAM:Phobius}.
FT DOMAIN 594 636 RING-type. {ECO:0000259|PROSITE:PS50089}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 593 636 ipfam:zf-RING_2 [T]
FT MYHIT 594 635 ismart:RING [T]
FT MYHIT 594 636 iprf:ZF_RING_2 [T]
SQ SEQUENCE 656 AA; 76246 MW; DB03046EF7AD68E9 CRC64;
MWWKLFFLLL YFFILFILAR FFEAIVWYET GIFATQLVDP VTLSFKKLKT ILECRGLGYS
GLAEKRDVRE LVENSGELMQ GELYSALKNE KEQAGSDSST TFSGEMHFYE LVEDTKDGIW
LVQVIAQDRN PLLSTANWGK MVQKVSQFGI RTGTFNCSSD SRYCHKRGWM KSTLIMSVPQ
TYASKGKVML KEYNGRRIET EHIFKWMTAH VASRIKTVRY SDQLMDDWYQ MEKQPVKMFL
FARLLQPPAF FSALSIKFTG RIEFIFVDVR NWDNNTCLEE IGVQQMPSYI LKTPEGIYRY
GNSTGEFISL HAMDTFLRSV QPEVNDLFIL SLVMVNLMAW MDLFITQGAT IKRFVVLIST
LGTYNSLLII SWLPILGFLQ LPYLDSFYEY SLKLLRYADT TTIASWVRAD WTFYSSHPAL
FLSTYLAHGL LIDYFEKKRR CSNEDQNANN LEWLSSLWDW YTSYLVHPIA SFQNFESDWD
DDPNFLLERL AFPDLWLRPL VPIDYIKNLP TWKFRLLQPE GSNLADRDKR QKAMMNQNED
SSGNKVAHQC SSDVLHDHYG CSAATKSEES WSGGEEQDTD WSQWPCGMLH CTECVVCLEN
FETDCLVMGL PCGHVFHQQC IVVWLAGGRH CCPVCRWPSY KKRPVRQRAT EQLDPE
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