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Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7

DescriptionSubName: Full=Amyloid-like protein 2 {ECO:0000313|Ensembl:ENSMUSP00000072428}; SubName: Full=Amyloid-like protein 2, isoform 751 {ECO:0000313|EMBL:AAA50603.1};
MyHits logo
MyHits synonymsQ60709_MOUSE , Q60709 , D183F6A4AD17BC04
match map segment
iprf:BPTI_KUNITZ_2 ipat:A4_EXTRA ipat:A4_INTRA ipfam:APP_E2 ipfam:Kunitz_BPTI ipfam:APP_N ipat:BPTI_KUNITZ_1 ismart:KU ipfam:APP_Cu_bd ismart:A4_EXTRA ipfam:APP_amyloid  
Legends: 1, SIGNAL {ECO:0000256|SAM:SignalP}; 2, TRANSMEM Helical. {ECO:0000256|SAM:Phobius}; 3, BPTI/Kunitz inhibitor. {ECO:0000259|PROSITE:PS50279}; 4, iprf:BPTI_KUNITZ_2 [T]; 5, ipat:A4_EXTRA [T]; 6, ipat:A4_INTRA [T]; 7, ipfam:Kunitz_BPTI [T]; 8, ipfam:APP_N [T]; 9, ipat:BPTI_KUNITZ_1 [T]; 10, ismart:KU [T]; 11, ipfam:APP_Cu_bd [T]; 12, ipfam:APP_amyloid [T]. 
ID   Q60709_MOUSE            Unreviewed;       751 AA.
AC   Q60709;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   10-MAY-2017, entry version 129.
DE   SubName: Full=Amyloid-like protein 2 {ECO:0000313|Ensembl:ENSMUSP00000072428};
DE   SubName: Full=Amyloid-like protein 2, isoform 751 {ECO:0000313|EMBL:AAA50603.1};
GN   Name=Aplp2 {ECO:0000313|Ensembl:ENSMUSP00000072428,
GN   ECO:0000313|MGI:MGI:88047};
GN   Synonyms=APLP2 {ECO:0000313|EMBL:AAA50603.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000313|EMBL:AAA50603.1}
RP   NUCLEOTIDE SEQUENCE OF 1-229.
RC   STRAIN=ICR {ECO:0000313|EMBL:AAA50603.1};
RX   PubMed=8300594;
RA   Slunt H.H., Thinakaran G., Von Koch C., Lo A.C., Tanzi R.E.,
RA   Sisodia S.S.;
RT   "Expression of a ubiquitous, cross-reactive homologue of the mouse
RT   beta-amyloid precursor protein (APP).";
RL   J. Biol. Chem. 269:2637-2644(1994).
RN   [2] {ECO:0000313|EMBL:AAA50603.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ICR {ECO:0000313|EMBL:AAA50603.1};
RX   PubMed=8071334;
RA   Thinakaran G., Sisodia S.S.;
RT   "Amyloid precursor-like protein 2 (APLP2) is modified by the addition
RT   of chondroitin sulfate glycosaminoglycan at a single site.";
RL   J. Biol. Chem. 269:22099-22104(1994).
RN   [3] {ECO:0000313|EMBL:AAA50603.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ICR {ECO:0000313|EMBL:AAA50603.1};
RA   Slunt H.H., Von Koch C., Sisodia S.S.;
RT   "Mouse Amyloid Precursor-Like Protein 2 (APLP2) mRNA, isoform APLP2-
RT   751,complete cds.";
RL   Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000072428, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000072428,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [5] {ECO:0000213|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
RN   [6] {ECO:0000313|Ensembl:ENSMUSP00000072428}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000072428};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC114542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CT025678; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; U15571; AAA50603.1; -; mRNA.
DR   PIR; A49974; A49974.
DR   RefSeq; NP_001095925.1; NM_001102455.1.
DR   UniGene; Mm.19133; -.
DR   STRING; 10090.ENSMUSP00000072428; -.
DR   MEROPS; I02.016; -.
DR   Ensembl; ENSMUST00000072634; ENSMUSP00000072428; ENSMUSG00000031996.
DR   GeneID; 11804; -.
DR   UCSC; uc009orm.1; mouse.
DR   CTD; 334; -.
DR   MGI; MGI:88047; Aplp2.
DR   eggNOG; KOG3540; Eukaryota.
DR   eggNOG; ENOG410ZW2A; LUCA.
DR   GeneTree; ENSGT00530000063252; -.
DR   HOVERGEN; HBG000051; -.
DR   OMA; TLYSYGM; -.
DR   OrthoDB; EOG091G0UW4; -.
DR   TreeFam; TF317274; -.
DR   ChiTaRS; Aplp2; mouse.
DR   Proteomes; UP000000589; Chromosome 9.
DR   Bgee; ENSMUSG00000031996; -.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0008201; F:heparin binding; IEA:InterPro.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   Gene3D; 3.30.1490.140; -; 1.
DR   Gene3D; 3.90.570.10; -; 1.
DR   Gene3D; 4.10.410.10; -; 1.
DR   InterPro; IPR008155; Amyloid_glyco.
DR   InterPro; IPR011178; Amyloid_glyco_Cu-bd.
DR   InterPro; IPR024329; Amyloid_glyco_E2_domain.
DR   InterPro; IPR008154; Amyloid_glyco_extra.
DR   InterPro; IPR019744; Amyloid_glyco_extracell_CS.
DR   InterPro; IPR015849; Amyloid_glyco_heparin-bd.
DR   InterPro; IPR019745; Amyloid_glyco_intracell_CS.
DR   InterPro; IPR019543; APP_amyloid_C.
DR   InterPro; IPR002223; Kunitz_BPTI.
DR   InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR   Pfam; PF10515; APP_amyloid; 1.
DR   Pfam; PF12924; APP_Cu_bd; 1.
DR   Pfam; PF12925; APP_E2; 1.
DR   Pfam; PF02177; APP_N; 1.
DR   Pfam; PF00014; Kunitz_BPTI; 1.
DR   PRINTS; PR00203; AMYLOIDA4.
DR   PRINTS; PR00759; BASICPTASE.
DR   SMART; SM00006; A4_EXTRA; 1.
DR   SMART; SM00131; KU; 1.
DR   SUPFAM; SSF109843; SSF109843; 1.
DR   SUPFAM; SSF56491; SSF56491; 1.
DR   SUPFAM; SSF57362; SSF57362; 1.
DR   SUPFAM; SSF89811; SSF89811; 1.
DR   PROSITE; PS00319; A4_EXTRA; 1.
DR   PROSITE; PS00320; A4_INTRA; 1.
DR   PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR   PROSITE; PS50279; BPTI_KUNITZ_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:Q60709,
KW   ECO:0000213|PeptideAtlas:Q60709};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     31       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        32    751       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5010141107.
FT   TRANSMEM    682    704       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      310    360       BPTI/Kunitz inhibitor.
FT                                {ECO:0000259|PROSITE:PS50279}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       310    360       iprf:BPTI_KUNITZ_2 [T]
FT   MYHIT       197    204       ipat:A4_EXTRA [T]
FT   MYHIT       737    744       ipat:A4_INTRA [T]
FT   MYHIT       366    547       ipfam:APP_E2 [T]
FT   MYHIT       309    361       ipfam:Kunitz_BPTI [T]
FT   MYHIT        49    147       ipfam:APP_N [T]
FT   MYHIT       338    356       ipat:BPTI_KUNITZ_1 [T]
FT   MYHIT       308    361       ismart:KU [T]
FT   MYHIT       148    204       ipfam:APP_Cu_bd [T]
FT   MYHIT        42    204       ismart:A4_EXTRA [T]
FT   MYHIT       697    747       ipfam:APP_amyloid [T]
SQ   SEQUENCE   751 AA;  85248 MW;  D183F6A4AD17BC04 CRC64;
     MAATGTAAAA ATGKLLVLLL LGLTAPAAAL AGYIEALAAN AGTGFAVAEP QIAMFCGKLN
     MHVNIQTGKW EPDPTGTKSC LGTKEEVLQY CQEIYPELQI TNVMEANQPV NIDSWCRRDK
     RQCKSHIVIP FKCLVGEFVS DVLLVPDNCQ FFHQERMEVC EKHQRWHTLV KEACLTEGLT
     LYSYGMLLPC GVDQFHGTEY VCCPQTKTVD SDSTMSKEEE EEEEDEEDEE EDYDLDKSEF
     PTEADLEDFT EAAADEEEED EEEGEEVVED RDYYYDPFKG DDYNEENPTE PSSEGTISDK
     EIVHDVKAVC SQEAMTGPCR AVMPRWYFDL SKGKCVRFIY GGCGGNRNNF ESEDYCMAVC
     KAMIPPTPLP TNDVDVYFET SADDNEHARF QKAKEQLEIR HRNRMDRVKK EWEEAELQAK
     NLPKTERQTL IQHFQAMVKA LEKEAASEKQ QLVETHLARV EAMLNDRRRI ALENYLAALQ
     SDPPRPHRIL QALRRYVRAE NKDRLHTIRH YQHVLAVDPE KAAQMKSQVM THLHVIEERR
     NQSLSLLYKV PYVAQEIQEE IDELLQEQRA DMDQFTSSIS ENPVDVRVSS EESEEIPPFH
     PLHPFPSLSE NEGSGMAEQD GGLIGAEEKV INSKNKMDEN MVIDETLDVK EMIFNAERVG
     GLEEEPESVG PLREDFSLSS NALIGLLVIA VAIATVIVIS LVMLRKRQYG TISHGIVEVD
     PMLTPEERHL NKMQNHGYEN PTYKYLEQMQ I
//