ID Q5SSC2_HUMAN Unreviewed; 199 AA.
AC Q5SSC2;
DT 21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 2.
DT 15-MAR-2017, entry version 76.
DE SubName: Full=Transmembrane protein 222 {ECO:0000313|Ensembl:ENSP00000419292};
DE Flags: Fragment;
GN Name=TMEM222 {ECO:0000313|Ensembl:ENSP00000419292};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000419292, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000419292}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA Waterston R.H., Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2
RT and 4.";
RL Nature 434:724-731(2005).
RN [2] {ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA Porter K.M., Prigmore E.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3] {ECO:0000313|Ensembl:ENSP00000419292}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JAN-2012) to UniProtKB.
CC -!- CAUTION: The sequence shown here is derived from an Ensembl
CC automatic analysis pipeline and should be considered as
CC preliminary data. {ECO:0000313|Ensembl:ENSP00000419292}.
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DR EMBL; FO393419; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR ProteinModelPortal; Q5SSC2; -.
DR MaxQB; Q5SSC2; -.
DR PeptideAtlas; Q5SSC2; -.
DR PRIDE; Q5SSC2; -.
DR Ensembl; ENST00000498220; ENSP00000419292; ENSG00000186501.
DR UCSC; uc057duu.1; human.
DR HGNC; HGNC:25363; TMEM222.
DR GeneTree; ENSGT00390000007371; -.
DR HOGENOM; HOG000231333; -.
DR HOVERGEN; HBG055708; -.
DR OMA; NSTGWNM; -.
DR ChiTaRS; TMEM222; human.
DR Proteomes; UP000005640; Chromosome 1.
DR Bgee; ENSG00000186501; -.
DR ExpressionAtlas; Q5SSC2; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR008496; DUF778.
DR PANTHER; PTHR20921; PTHR20921; 1.
DR Pfam; PF05608; DUF778; 2.
PE 1: Evidence at protein level;
KW Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0000213|EPD:Q5SSC2,
KW ECO:0000213|MaxQB:Q5SSC2, ECO:0000213|PeptideAtlas:Q5SSC2};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 154 172 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 178 198 Helical. {ECO:0000256|SAM:Phobius}.
FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000419292}.
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CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 110 169 ipfam:DUF778 [T]
FT MYHIT 27 102 ipfam:DUF778 [T]
SQ SEQUENCE 199 AA; 22447 MW; 6E7C07F291C20ECA CRC64;
KQYQGSGGVA MDVERSRFPY CVVWTPIPVL TWFFPIIGHM GICTSTGVIR DFAGPYFVSE
DNMAFGKPAK CHLQEAFSHP ILVRSGCHNK ISSIGYWKLD PAQVYASGPN AWDTAVHDAS
EEYKHRMHNL CCDNCHSHVA LALNLMRYNN STNWNMVTLC FFCLLYGKYV SVGAFVKTWL
PFILLLGIIL TVSLVFNLR
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