Entry euk:Q5RH62_DANRE

ID   Q5RH62_DANRE            Unreviewed;       764 AA.
AC   Q5RH62; Q156I9;
DT   21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 2.
DT   10-MAY-2017, entry version 83.
DE   SubName: Full=Cation/H+ exchanger protein 1 {ECO:0000313|Ensembl:ENSDARP00000067045};
DE   SubName: Full=Si:dkey-180p18.2 {ECO:0000313|EMBL:AAI33107.1};
DE   SubName: Full=Type II CAX cation/proton exchanger {ECO:0000313|EMBL:ABG21181.1};
GN   Name=cax1 {ECO:0000313|EMBL:ABG21181.1,
GN   ECO:0000313|Ensembl:ENSDARP00000067045,
GN   ECO:0000313|ZFIN:ZDB-GENE-030131-3044};
GN   Synonyms=si:dkey-180p18.2 {ECO:0000313|EMBL:AAI33107.1,
GN   ECO:0000313|ZFIN:ZDB-GENE-030131-3044};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000313|EMBL:ABG21181.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Shigaki T., Hirschi K.D.;
RT   "Cloning and characterization of the first CAX transporter from an
RT   animal species.";
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAI33107.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Whole body {ECO:0000313|EMBL:AAI33107.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000067045}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000067045};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [4] {ECO:0000313|Ensembl:ENSDARP00000067045, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000067045,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
CC   -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA)
CC       (TC 2.A.19) family. {ECO:0000256|SAAS:SAAS00611730}.
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DR   EMBL; BX571796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC133106; AAI33107.1; -; mRNA.
DR   EMBL; DQ631793; ABG21181.1; -; mRNA.
DR   RefSeq; NP_001020678.2; NM_001025507.3.
DR   UniGene; Dr.48773; -.
DR   STRING; 7955.ENSDARP00000067045; -.
DR   Ensembl; ENSDART00000067046; ENSDARP00000067045; ENSDARG00000045601.
DR   GeneID; 560283; -.
DR   KEGG; dre:560283; -.
DR   CTD; 560283; -.
DR   ZFIN; ZDB-GENE-030131-3044; cax1.
DR   eggNOG; KOG1397; Eukaryota.
DR   eggNOG; COG0387; LUCA.
DR   GeneTree; ENSGT00390000016897; -.
DR   HOVERGEN; HBG054035; -.
DR   OMA; SITEMAF; -.
DR   OrthoDB; EOG091G02OA; -.
DR   TreeFam; TF333883; -.
DR   Proteomes; UP000000437; Chromosome 4.
DR   Bgee; ENSDARG00000045601; -.
DR   GO; GO:0012505; C:endomembrane system; IDA:ZFIN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0006816; P:calcium ion transport; IDA:ZFIN.
DR   GO; GO:0014032; P:neural crest cell development; IMP:ZFIN.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR004837; NaCa_Exmemb.
DR   InterPro; IPR005185; YccF.
DR   Pfam; PF01699; Na_Ca_ex; 2.
DR   Pfam; PF03733; YccF; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Membrane {ECO:0000256|SAAS:SAAS00087593, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00087593,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00087593,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    158    186       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    274    300       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    358    377       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    389    406       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    418    439       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    459    481       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    493    513       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    560    580       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    613    632       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    677    700       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    706    731       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    738    758       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      156    205       YccF. {ECO:0000259|Pfam:PF03733}.
FT   DOMAIN      391    506       Na_Ca_ex. {ECO:0000259|Pfam:PF01699}.
FT   DOMAIN      614    754       Na_Ca_ex. {ECO:0000259|Pfam:PF01699}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
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FT   MYHIT       156    205       ipfam:YccF [T]
FT   MYHIT       391    505       ipfam:Na_Ca_ex [T]
FT   MYHIT       614    754       ipfam:Na_Ca_ex [T]
SQ   SEQUENCE   764 AA;  85199 MW;  1A472C6928EF0948 CRC64;
     MAQIKPTMSV DVESRRRRST ESSEPFLDHD PKGRRCSSQC DRLCVAGAYH EIPDTPSPCT
     SQYFGHYTPK CLSAHRHSMH ARCPEDIWQE ASIRTSIRAE NEVEAHKVAN NYKFGFRKWK
     SHVTERPIED RSDVVKELYS ELNYVKQLSG SLVTAGNIVY VLLFGWWISL FYFLVGLLMF
     FTIAGIPYGK LCLQLSGYFI WPFGKALQKS SSLVKRCCVK FPHCEAIPEE VDEVKEPLKE
     STPLLHSGPA VTAEIPVPAP PTKPTRYWCR LSTYVWLILG YPLLAVVHCL AMFLSWMMVF
     TIPVSKMNAR TLSLILLMPP EQVKVRNVKK PQGCETRVLL CCYRAFNWYY YKYTVDGINV
     FAVNLLPLVI ITLIIGYMDR ENYFVSSEVK FATALISIIP LSYYIGMGIA SISAQSNFAV
     GAVVNATFGS ITEMAFYITA LLQGQRAGSQ CYAELVKSAL TGTLLGCILF IPGLCMIIGG
     FKHSEQRFNS RSAGVSSALL FISVGGVFAP TLFSKAYGNF ICEGCNNPPG NISKPFICNN
     CHYDLSENNR PLFLSHIEPL VYTVSVLLPA AYLVGLIFTL KTHSHIYDIH ISDGHCHVIS
     DHHAVAHWSR TRALVVLILA TILMAACADL STEHIKPIIS NSSVSQYFIG VTIIAMVPEL
     PEIVNGVQFA LQNNISLSLE VGSCLAVQVC MLQIPLLILF NAFYDVGFVL IFSDLHLWAS
     IFSVILVNYI FMDGKSDYFQ GTALVVVYLI LLALYFFAPA PLGC
//