ID Q5QKM9_DANRE Unreviewed; 264 AA.
AC Q5QKM9;
DT 04-JAN-2005, integrated into UniProtKB/TrEMBL.
DT 04-JAN-2005, sequence version 1.
DT 10-MAY-2017, entry version 93.
DE SubName: Full=Deoxycytidine kinase 2 {ECO:0000313|EMBL:AAO64438.1};
DE EC=2.7.1.74 {ECO:0000313|EMBL:AAO64438.1};
DE SubName: Full=Zgc:110540 {ECO:0000313|EMBL:AAI53550.1, ECO:0000313|Ensembl:ENSDARP00000004823};
DE SubName: Full=Zgc:110540 protein {ECO:0000313|EMBL:AAH95077.1};
GN Name=DCK2 {ECO:0000313|EMBL:AAO64438.1};
GN ORFNames=zgc:110540 {ECO:0000313|EMBL:AAH95077.1,
GN ECO:0000313|Ensembl:ENSDARP00000004823,
GN ECO:0000313|ZFIN:ZDB-GENE-050327-77};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000313|EMBL:AAI53550.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Whole body {ECO:0000313|EMBL:AAI53550.1};
RX PubMed=12477932; DOI=10.1073/pnas.242603899;
RG Mammalian Gene Collection Program Team;
RA Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD,
RA Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B,
RA Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T,
RA Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA,
RA Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL,
RA Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P,
RA Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ,
RA Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S,
RA Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM,
RA Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A,
RA Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y,
RA Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC,
RA Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS,
RA Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE,
RA Jones SJ Marra.MA.;
RT "Generation and initial analysis of more than 15,000 full-length human
RT and mouse cDNA sequences.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN [2] {ECO:0000313|EMBL:AAO64438.1}
RP NUCLEOTIDE SEQUENCE.
RA Sandrini M.P.B., Piskur J.;
RT "Zebrafish deoxyribonucleoside kinases.";
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AAH95077.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye {ECO:0000313|EMBL:AAH95077.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AAI53550.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Whole body {ECO:0000313|EMBL:AAI53550.1};
RG NIH MGC Project;
RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:AAI71341.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pooled {ECO:0000313|EMBL:AAI71341.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|Ensembl:ENSDARP00000004823}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000004823};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [7] {ECO:0000313|Ensembl:ENSDARP00000004823, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000004823,
RC ECO:0000313|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S.,
RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the
RT human genome.";
RL Nature 496:498-503(2013).
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DR EMBL; CR354383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC095077; AAH95077.1; -; mRNA.
DR EMBL; BC153549; AAI53550.1; -; mRNA.
DR EMBL; BC171341; AAI71341.1; -; mRNA.
DR EMBL; BC171343; AAI71343.1; -; mRNA.
DR EMBL; AY192988; AAO64438.1; -; mRNA.
DR UniGene; Dr.78188; -.
DR STRING; 7955.ENSDARP00000004823; -.
DR Ensembl; ENSDART00000009889; ENSDARP00000004823; ENSDARG00000054929.
DR ZFIN; ZDB-GENE-050327-77; zgc:110540.
DR eggNOG; KOG4235; Eukaryota.
DR eggNOG; COG1428; LUCA.
DR GeneTree; ENSGT00510000046588; -.
DR HOVERGEN; HBG006216; -.
DR OMA; EPIAKWC; -.
DR OrthoDB; EOG091G0G7H; -.
DR TreeFam; TF324413; -.
DR Proteomes; UP000000437; Chromosome 21.
DR Bgee; ENSDARG00000054929; -.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004137; F:deoxycytidine kinase activity; IEA:UniProtKB-EC.
DR InterPro; IPR002624; DCK/DGK.
DR InterPro; IPR031314; DNK_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01712; dNK; 1.
DR PIRSF; PIRSF000705; DNK; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 1: Evidence at protein level;
KW Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW Kinase {ECO:0000313|EMBL:AAO64438.1};
KW Proteomics identification {ECO:0000213|PeptideAtlas:Q5QKM9};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transferase {ECO:0000313|EMBL:AAO64438.1}.
FT DOMAIN 25 261 dNK. {ECO:0000259|Pfam:PF01712}.
FT ACT_SITE 128 128 Proton acceptor.
FT {ECO:0000256|PIRSR:PIRSR000705-1}.
FT BINDING 54 54 Substrate.
FT {ECO:0000256|PIRSR:PIRSR000705-2}.
FT BINDING 87 87 Substrate.
FT {ECO:0000256|PIRSR:PIRSR000705-2}.
FT BINDING 98 98 Substrate.
FT {ECO:0000256|PIRSR:PIRSR000705-2}.
FT BINDING 129 129 Substrate.
FT {ECO:0000256|PIRSR:PIRSR000705-2}.
FT BINDING 134 134 Substrate.
FT {ECO:0000256|PIRSR:PIRSR000705-2}.
FT BINDING 198 198 Substrate.
FT {ECO:0000256|PIRSR:PIRSR000705-2}.
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CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 25 261 ipfam:dNK [T]
SQ SEQUENCE 264 AA; 31135 MW; 8D99CCBAD2DB6174 CRC64;
MATPPKRLCS SFDADLSFEK RAMKVSIEGN IAAGKSTFVR LLERASEEWE VIPEPIGKWC
NVQTTENEYE ELSTSQKSGG NLLQMLYDKP SRWSYTFQTY ACLSRVRSQL QPPSAKLQQA
EKPVQFFERS VYSDRYVFAS NLFESGDLNE TEWAIYQDWH SWLLTQFESQ IELDAMIYLR
ADPERCMQRL QFRGREEEQG IPLDYLEKLH YKHECWLYNQ TTKLDFEYLK DLPILILDVN
EDFKNDRIKQ EGVIDKVKEF LNSL
//
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