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Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7

DescriptionSubName: Full=ATP-dependent Clp protease subunit, heat shock protein 100 (HSP100), putative {ECO:0000313|EMBL:AAX79014.1};
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MyHits synonymsQ586B8_TRYB2 , Q586B8 , D7SG76 , E46124D38A38D4E9
match map segment
ipfam:AAA ismart:AAA ipat:CLPAB_1 ismart:AAA ismart:ClpB_D2-small ipfam:ClpB_D2-small ipfam:AAA_2 ipfam:Clp_N ipfam:Clp_N ipat:CLPAB_2  
Legends: 1, AAA. {ECO:0000259|SMART:SM00382}; 2, ClpB_D2-small. {ECO:0000259|SMART:SM01086}; 3, COILED {ECO:0000256|SAM:Coils}; 4, ipat:CLPAB_1 [T]; 5, ismart:ClpB_D2-small [T]; 6, ipfam:ClpB_D2-small [T]; 7, ipfam:Clp_N [T]; 8, ipat:CLPAB_2 [T]. 
ID   Q586B8_TRYB2            Unreviewed;       870 AA.
AC   Q586B8; D7SG76;
DT   30-MAY-2006, integrated into UniProtKB/TrEMBL.
DT   30-MAY-2006, sequence version 1.
DT   10-MAY-2017, entry version 93.
DE   SubName: Full=ATP-dependent Clp protease subunit, heat shock protein 100 (HSP100), putative {ECO:0000313|EMBL:AAX79014.1};
GN   ORFNames=Tb927.2.5980 {ECO:0000313|EMBL:AAX79014.1};
OS   Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=185431 {ECO:0000313|Proteomes:UP000008524};
RN   [1] {ECO:0000313|EMBL:AAX79014.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX79014.1};
RA   Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA   Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J.,
RA   Johnson J., Jones K., Koo H.L., Larkin C., Pai G., Peterson J.,
RA   Khalak H.G., Salzberg S., Simpson A.J., Tallon L., Van Aken S.,
RA   Wanless D., White O., Wortman J., Fraser C.M., El-Sayed N.M.A.;
RL   Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAX79014.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX79014.1};
RA   El-Sayed N.M., Khalak H., Adams M.D.;
RL   Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:AAQ16055.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAQ16055.1};
RX   PubMed=16020724; DOI=10.1126/science.1112181;
RA   El-Sayed N.M., Myler P.J., Blandin G., Berriman M., Crabtree J.,
RA   Aggarwal G., Caler E., Renauld H., Worthey E.A., Hertz-Fowler C.,
RA   Ghedin E., Peacock C., Bartholomeu D.C., Haas B.J., Tran A.N.,
RA   Wortman J.R., Alsmark U.C., Angiuoli S., Anupama A., Badger J.,
RA   Bringaud F., Cadag E., Carlton J.M., Cerqueira G.C., Creasy T.,
RA   Delcher A.L., Djikeng A., Embley T.M., Hauser C., Ivens A.C.,
RA   Kummerfeld S.K., Pereira-Leal J.B., Nilsson D., Peterson J.,
RA   Salzberg S.L., Shallom J., Silva J.C., Sundaram J., Westenberger S.,
RA   White O., Melville S.E., Donelson J.E., Andersson B., Stuart K.D.,
RA   Hall N.;
RT   "Comparative genomics of trypanosomatid parasitic protozoa.";
RL   Science 309:404-409(2005).
RN   [4] {ECO:0000313|EMBL:AAQ16055.1, ECO:0000313|Proteomes:UP000008524}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAQ16055.1,
RC   ECO:0000313|Proteomes:UP000008524};
RX   PubMed=16020726; DOI=10.1126/science.1112642;
RA   Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA   Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B.,
RA   Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L.,
RA   Wickstead B., Alsmark U.C.M., Arrowsmith C., Atkin R.J., Barron A.J.,
RA   Bringaud F., Brooks K., Carrington M., Cherevach I.,
RA   Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A.,
RA   Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C.,
RA   Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H.,
RA   Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K.,
RA   Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V.,
RA   Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M.,
RA   Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA   Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S.,
RA   Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A.,
RA   Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B.,
RA   White O., Whitehead S., Woodward J., Wortman J., Adams M.D.,
RA   Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H.,
RA   Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M.,
RA   Melville S.E., El-Sayed N.M.A.;
RT   "The genome of the African trypanosome Trypanosoma brucei.";
RL   Science 309:416-422(2005).
RN   [5] {ECO:0000313|EMBL:AAX79014.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX79014.1};
RA   Haas B., Blandin G., El-Sayed N.;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC       {ECO:0000256|RuleBase:RU004432}.
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DR   EMBL; AE017150; AAQ16055.1; -; Genomic_DNA.
DR   EMBL; AC008368; AAX79014.1; -; Genomic_DNA.
DR   RefSeq; XP_951738.1; XM_946645.1.
DR   EnsemblProtists; AAQ16055; AAQ16055; Tb927.2.5980.
DR   GeneDB; Tb927.2.5980:pep; -.
DR   GeneID; 3655899; -.
DR   KEGG; tbr:Tb927.2.5980; -.
DR   EuPathDB; TriTrypDB:Tb927.2.5980; -.
DR   HOGENOM; HOG000218211; -.
DR   KO; K03695; -.
DR   OMA; IAIHILR; -.
DR   Proteomes; UP000008524; Chromosome 2.
DR   GO; GO:0005886; C:plasma membrane; IDA:GeneDB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1780.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR004176; Clp_N.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR018368; ClpA/B_CS1.
DR   InterPro; IPR028299; ClpA/B_CS2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF02861; Clp_N; 2.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   SUPFAM; SSF81923; SSF81923; 1.
DR   PROSITE; PS00870; CLPAB_1; 1.
DR   PROSITE; PS00871; CLPAB_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU004432};
KW   Chaperone {ECO:0000256|RuleBase:RU004432};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008524};
KW   Hydrolase {ECO:0000313|EMBL:AAX79014.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU004432};
KW   Protease {ECO:0000313|EMBL:AAX79014.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008524};
KW   Stress response {ECO:0000313|EMBL:AAX79014.1}.
FT   DOMAIN      197    342       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      597    768       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      767    858       ClpB_D2-small.
FT                                {ECO:0000259|SMART:SM01086}.
FT   COILED      411    453       {ECO:0000256|SAM:Coils}.
FT   COILED      461    491       {ECO:0000256|SAM:Coils}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       202    315       ipfam:AAA [T]
FT   MYHIT       197    342       ismart:AAA [T]
FT   MYHIT       293    305       ipat:CLPAB_1 [T]
FT   MYHIT       597    768       ismart:AAA [T]
FT   MYHIT       767    858       ismart:ClpB_D2-small [T]
FT   MYHIT       767    847       ipfam:ClpB_D2-small [T]
FT   MYHIT       597    761       ipfam:AAA_2 [T]
FT   MYHIT        94    143       ipfam:Clp_N [T]
FT   MYHIT        19     57       ipfam:Clp_N [T]
FT   MYHIT       631    649       ipat:CLPAB_2 [T]
SQ   SEQUENCE   870 AA;  97038 MW;  E46124D38A38D4E9 CRC64;
     MAHSDRQCTN AAQTALSDAV ESARKHNNGF VDPAHLALVL FKNEDGLASR VLRKLNAGTV
     LEPLAARVGA LPEQRPAPAV PSPSPAMVVV LNTAEQKRIE WGDSLIAVDH LLIGLFECKE
     VEAIMKAAHA SKKAVEGALL ELRKGKKVTS EFQEENYQAL EKYATDLCKL AEEGKLDPVI
     GRTDEVLRTI RVLSRRTKNN PILIGEPGVG KTAIAEGIAQ RIVRGDVPDT LLNTRLFSLD
     LGALIAGSSL RGEFEERLKS VLNEVKESSN GVILFIDEIH LVLGAGKSGG SMDAANLLKP
     MLARGELRTI GATTLEEYRT YVEKDAAFER RFMPVYVTEP SVEECISILR GLKDRYEAHH
     GVQITDNAVV VAAQLANRYI TNRFMPDKAI DLIDEACANV RVQLSSRPEA IDILERKKRQ
     LEIEAKALER DKEAASRERL KLVKADIQRV EEELQPLVSK YNDERQRIDE LQEMQSRLDE
     KKNKLERAVR DGKMDLAADL QYNVIPLIQD RIRSLKEDIE RQKATLVQEK VTEGDVAAVV
     ARWTGIPVVK LSQTDRERLL NLSMHLHRRV KGQDEAVERV ADAIIRARAG LSRPNSPTAS
     FLFLGPTGVG KTELVKAVAA ELFDDEKHMV RIDMSEYMEQ HSVSRLIGAP PGYIGHDEGG
     QLTEPVRRRP HAVVLFDEVE KAHPNVYNVL LQVLDDGRLT DSRGRTVDFS NTIIVMTSNL
     GSEHLLNPEE TNESYEVLRE NVLAAVRSYF RPELINRLDD IVVFRRLRTE DLRGVVDNLI
     AGVNERLKSS GFSVLLDDGV KDFILEHGHD ANMGARPLRR WIEKNIVTEI GRMLIAKELP
     PNSTLRVSLP EGGNKLTFGV KRGLTSDEWE
//