Entry euk:Q4QB47_LEIMA

ID   Q4QB47_LEIMA            Unreviewed;       672 AA.
AC   Q4QB47;
DT   19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   19-JUL-2005, sequence version 1.
DT   10-MAY-2017, entry version 53.
DE   RecName: Full=Probable methyltransferase BMT2 homolog {ECO:0000256|HAMAP-Rule:MF_03044};
DE            EC=2.1.1.- {ECO:0000256|HAMAP-Rule:MF_03044};
GN   ORFNames=LMJF_23_1090 {ECO:0000313|EMBL:CAJ04677.1};
OS   Leishmania major.
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae;
OC   Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5664 {ECO:0000313|Proteomes:UP000000542};
RN   [1] {ECO:0000313|EMBL:CAJ04677.1, ECO:0000313|Proteomes:UP000000542}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX   PubMed=16020728; DOI=10.1126/science.1112680;
RA   Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA   Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA   Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA   Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M.,
RA   Cadag E., Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K.,
RA   Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A.,
RA   Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C.,
RA   Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D.,
RA   Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L.,
RA   Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S.,
RA   Mottram J.C., Muller-Auer S., Munden H., Nelson S., Norbertczak H.,
RA   Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B.,
RA   Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J.,
RA   Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D.,
RA   Schafer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S.,
RA   Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C.,
RA   Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S.,
RA   Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.,
RA   Myler P.J.;
RT   "The genome of the kinetoplastid parasite, Leishmania major.";
RL   Science 309:436-442(2005).
RN   [2] {ECO:0000313|EMBL:CAJ04677.1, ECO:0000313|Proteomes:UP000000542}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural
RT   change between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
CC   -!- FUNCTION: Probable S-adenosyl-L-methionine-dependent
CC       methyltransferase. {ECO:0000256|HAMAP-Rule:MF_03044}.
CC   -!- SIMILARITY: Belongs to the BMT2 family. {ECO:0000256|HAMAP-
CC       Rule:MF_03044}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; FR796419; CAJ04677.1; -; Genomic_DNA.
DR   RefSeq; XP_001683451.1; XM_001683399.1.
DR   ProteinModelPortal; Q4QB47; -.
DR   EnsemblProtists; LmjF.23.1090:mRNA; LmjF.23.1090:pep; LmjF.23.1090.
DR   GeneDB; LmjF.23.1090:pep; -.
DR   GeneID; 5652100; -.
DR   KEGG; lma:LMJF_23_1090; -.
DR   eggNOG; ENOG410IH2N; Eukaryota.
DR   eggNOG; ENOG410XT5Y; LUCA.
DR   HOGENOM; HOG000257494; -.
DR   InParanoid; Q4QB47; -.
DR   OMA; GRMATEA; -.
DR   Proteomes; UP000000542; Chromosome 23.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0016433; F:rRNA (adenine) methyltransferase activity; IBA:GO_Central.
DR   HAMAP; MF_03044; BMT2; 1.
DR   InterPro; IPR021867; Bmt2.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   PANTHER; PTHR21008; PTHR21008; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000542};
KW   Methyltransferase {ECO:0000256|HAMAP-Rule:MF_03044};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW   S-adenosyl-L-methionine {ECO:0000256|HAMAP-Rule:MF_03044};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_03044}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT        44    662       ihamap:BMT2 [T]
SQ   SEQUENCE   672 AA;  71161 MW;  5958CF7A0E85F1A7 CRC64;
     MSSEKLQHAR NGAGGDHESL SHAPLPESPS QAPALTSTSQ SEAVSTEHLV WASLIKEQHR
     YLQAAVQSGV SGSGTAVTAM GALSCLTASA PPPSYREELK AWRCTLTGEA AAQRLSAYAE
     AMHHLATLYW NPSATPLAGH SGGADDSGRA RVEPGAHGGR AGAFESTAPR LGEKRKRSSD
     TAGGVQTPPS AVVIGEAMPA TVTATMSDTH SRHYSDRLGY CLQSIASYYL GEAETEGCGE
     GTADGAPHAA DCRPSAAAQS PSPPCFRVCV EQTRFRQLPG VFARVVKPLR RLFFQRYGRM
     ATEAEVGQLI SVCTPSRDDS CSIAPKKSRA GSFSCSSSST DSSGGSTTAV CAARQLIDAD
     VDARAIVEES TWRRSEHTAW ATALHYTRGA PHPTPTSAPA PLWTLDVGSC YGPFFGTILS
     RAAPLAPVPL HVTSMDLAPY QGAAGCDTGS NGVPSPCVWR ADWLQMEFFA EEPETDEAVR
     GCSTGVAFGT AEEGRVRYQR QRPASSLADG GGNSGLHPCD SREGSAGNAA QRSLAATAVR
     LESYDAVFFC LLLSYIPTPR LRFLACIHAF LALKEGGLLV IVSTRTQGPR RRNWMSEWTA
     CLASIGFQRV QQSIQEKLVG MSFAKVSPSA EVRRSWATAE GRAAWIESLM TSSAALEGLR
     ITADDARSCA DI
//