Entry euk:Q24JV2_DANRE

ID   Q24JV2_DANRE            Unreviewed;       153 AA.
AC   Q24JV2;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   18-APR-2006, sequence version 1.
DT   10-MAY-2017, entry version 82.
DE   SubName: Full=ORMDL sphingolipid biosynthesis regulator 2 {ECO:0000313|Ensembl:ENSDARP00000075272};
DE   SubName: Full=Zgc:136901 {ECO:0000313|EMBL:AAI14304.1};
GN   Name=ormdl2 {ECO:0000313|Ensembl:ENSDARP00000075272,
GN   ECO:0000313|ZFIN:ZDB-GENE-060331-113};
GN   Synonyms=zgc:136901 {ECO:0000313|EMBL:AAI14304.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI14304.1};
RN   [1] {ECO:0000313|EMBL:AAI14304.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Whole {ECO:0000313|EMBL:AAI14304.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000075272}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000075272};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000075272, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000075272,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
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DR   EMBL; BX927210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC114303; AAI14304.1; -; mRNA.
DR   RefSeq; NP_001035137.1; NM_001040048.1.
DR   RefSeq; XP_009295264.1; XM_009296989.2.
DR   RefSeq; XP_009295265.1; XM_009296990.2.
DR   UniGene; Dr.76878; -.
DR   STRING; 7955.ENSDARP00000120650; -.
DR   Ensembl; ENSDART00000080826; ENSDARP00000075272; ENSDARG00000058022.
DR   Ensembl; ENSDART00000134550; ENSDARP00000120650; ENSDARG00000058022.
DR   GeneID; 677753; -.
DR   KEGG; dre:677753; -.
DR   CTD; 29095; -.
DR   ZFIN; ZDB-GENE-060331-113; ormdl2.
DR   eggNOG; KOG3319; Eukaryota.
DR   eggNOG; COG5081; LUCA.
DR   GeneTree; ENSGT00390000015817; -.
DR   HOGENOM; HOG000192741; -.
DR   HOVERGEN; HBG080033; -.
DR   OMA; VPLVWTL; -.
DR   OrthoDB; EOG091G0S5I; -.
DR   TreeFam; TF323369; -.
DR   Reactome; R-DRE-1660661; Sphingolipid de novo biosynthesis.
DR   Proteomes; UP000000437; Chromosome 23.
DR   Bgee; ENSDARG00000058022; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0035339; C:SPOTS complex; IBA:GO_Central.
DR   GO; GO:0090156; P:cellular sphingolipid homeostasis; IBA:GO_Central.
DR   GO; GO:0006672; P:ceramide metabolic process; IEA:InterPro.
DR   GO; GO:1900060; P:negative regulation of ceramide biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR007203; ORMDL.
DR   InterPro; IPR029886; ORML2.
DR   PANTHER; PTHR12665; PTHR12665; 1.
DR   PANTHER; PTHR12665:SF21; PTHR12665:SF21; 1.
DR   Pfam; PF04061; ORMDL; 1.
DR   PIRSF; PIRSF018147; ORMDL; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     21     40       Helical. {ECO:0000256|SAM:Phobius}.
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CC   The following FT lines are automated annotations from the MyHits database.
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FT   MYHIT        11    146       ipfam:ORMDL [T]
SQ   SEQUENCE   153 AA;  17389 MW;  BE5BBC80893AC569 CRC64;
     MNVGVAHSEV NPNTRVMNSR GIWLAYLLLT TALHVVLLSI PFLSVPVVWT LTNIIHNLAM
     YLFLHTVKGT PFETPDQGKA RLLTHWEQMD YGIQFTASRK FLTISPIVLY ILASFYTKYD
     TTHFLVNTGS LLSVLLPKLP QFHGVRLFGI NKY
//