ID Q1LX85_DANRE Unreviewed; 281 AA.
AC Q1LX85;
DT 30-MAY-2006, integrated into UniProtKB/TrEMBL.
DT 30-MAY-2006, sequence version 1.
DT 15-MAR-2017, entry version 80.
DE SubName: Full=Pim proto-oncogene, serine/threonine kinase,-related 173 {ECO:0000313|Ensembl:ENSDARP00000116433};
DE Flags: Fragment;
GN Name=pimr173 {ECO:0000313|Ensembl:ENSDARP00000116433,
GN ECO:0000313|ZFIN:ZDB-GENE-041210-89};
GN Synonyms=pcloa {ECO:0000313|ZFIN:ZDB-GENE-041210-89},
GN si:dkey-108d22.5 {ECO:0000313|ZFIN:ZDB-GENE-041210-89};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000116433, ECO:0000313|Proteomes:UP000000437};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000116433, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000116433,
RC ECO:0000313|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S.,
RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the
RT human genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000116433}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000116433};
RG Ensembl;
RL Submitted (MAY-2013) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily.
CC {ECO:0000256|RuleBase:RU000304}.
CC -!- CAUTION: The sequence shown here is derived from an Ensembl
CC automatic analysis pipeline and should be considered as
CC preliminary data. {ECO:0000313|Ensembl:ENSDARP00000116433}.
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DR EMBL; BX469931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR ProteinModelPortal; Q1LX85; -.
DR STRING; 7955.ENSDARP00000116433; -.
DR PaxDb; Q1LX85; -.
DR Ensembl; ENSDART00000140018; ENSDARP00000116433; ENSDARG00000070015.
DR ZFIN; ZDB-GENE-041210-89; pimr173.
DR eggNOG; KOG0583; Eukaryota.
DR eggNOG; COG0515; LUCA.
DR GeneTree; ENSGT00760000119045; -.
DR HOVERGEN; HBG106846; -.
DR InParanoid; Q1LX85; -.
DR PhylomeDB; Q1LX85; -.
DR TreeFam; TF320810; -.
DR Proteomes; UP000000437; Chromosome 4.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR InterPro; IPR011009; Kinase-like_dom.
DR InterPro; IPR017348; PIM1/2/3.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF00069; Pkinase; 1.
DR PIRSF; PIRSF037993; STPK_Pim-1; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR037993-2,
KW ECO:0000256|RuleBase:RU000304};
KW Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW Kinase {ECO:0000256|RuleBase:RU000304};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR037993-2,
KW ECO:0000256|RuleBase:RU000304};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000304};
KW Transferase {ECO:0000256|RuleBase:RU000304}.
FT DOMAIN 7 281 Protein kinase.
FT {ECO:0000259|PROSITE:PS50011}.
FT ACT_SITE 140 140 Proton acceptor.
FT {ECO:0000256|PIRSR:PIRSR037993-1}.
FT BINDING 36 36 ATP. {ECO:0000256|PIRSR:PIRSR037993-2}.
FT BINDING 93 93 ATP; via carbonyl oxygen.
FT {ECO:0000256|PIRSR:PIRSR037993-2}.
FT BINDING 100 100 ATP. {ECO:0000256|PIRSR:PIRSR037993-2}.
FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSDARP00000116433}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 136 148 ipat:PROTEIN_KINASE_ST [T]
FT MYHIT 7 280 ismart:S_TKc [T]
FT MYHIT 7 218 ipfam:Pkinase [T]
FT MYHIT 13 36 ipat:PROTEIN_KINASE_ATP [T]
FT MYHIT 7 281 iprf:PROTEIN_KINASE_DOM [T]
SQ SEQUENCE 281 AA; 31878 MW; 02C1BD5A61184BB7 CRC64;
DIILRHYKIG DKLGKGGFGS VYKATRRRDG LKVAVKCTVK SSKMKEITVP GYDKPLPTEI
ALTIMANNGP YVPEIIKLLD WEDNDDHYVI IMERPIPCMD LFCFLNHNNG PLDEKTGRHI
MRQAIHAVSV CFNRGVFHRD IKLENLLVNP DTLEVKLIDF GCGAIAKESG YKVFCGTREY
FPPEYELYGR YHAQPATVWS LGIVLFAMMC WALPTVSDHS LIRDYLWTRT DLSKGHGVRQ
EKQLSNPSTP EDCCIGLLFV LYCCLVNFCN NAGQLTYECL C
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