Entry euk:Q0P445_DANRE

ID   Q0P445_DANRE            Unreviewed;       371 AA.
AC   Q0P445;
DT   19-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   19-SEP-2006, sequence version 1.
DT   10-MAY-2017, entry version 99.
DE   SubName: Full=Gamma-aminobutyric acid (GABA) A receptor, rho 2a {ECO:0000313|Ensembl:ENSDARP00000069422};
DE   SubName: Full=Zgc:153417 {ECO:0000313|EMBL:AAI22283.1};
DE   SubName: Full=Zgc:153417 protein {ECO:0000313|EMBL:AAI64465.1};
GN   Name=gabrr2a {ECO:0000313|Ensembl:ENSDARP00000069422,
GN   ECO:0000313|ZFIN:ZDB-GENE-060825-164};
GN   Synonyms=zgc:153417 {ECO:0000313|EMBL:AAI22283.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI22283.1};
RN   [1] {ECO:0000313|EMBL:AAI22283.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye {ECO:0000313|EMBL:AAI22283.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAI64465.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=PCR rescue {ECO:0000313|EMBL:AAI64465.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000069422}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000069422};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [4] {ECO:0000313|Ensembl:ENSDARP00000069422, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000069422,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
CC   -!- SUBCELLULAR LOCATION: Cell junction, synapse
CC       {ECO:0000256|SAAS:SAAS00548273}.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|RuleBase:RU000687,
CC       ECO:0000256|SAAS:SAAS00569405}.
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DR   EMBL; CR759878; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC122282; AAI22283.1; -; mRNA.
DR   EMBL; BC164465; AAI64465.1; -; mRNA.
DR   RefSeq; NP_001038841.1; NM_001045376.1.
DR   UniGene; Dr.90380; -.
DR   STRING; 7955.ENSDARP00000110159; -.
DR   Ensembl; ENSDART00000074936; ENSDARP00000069422; ENSDARG00000052982.
DR   GeneID; 751659; -.
DR   KEGG; dre:751659; -.
DR   CTD; 751659; -.
DR   ZFIN; ZDB-GENE-060825-164; gabrr2a.
DR   eggNOG; KOG3643; Eukaryota.
DR   eggNOG; ENOG410XPWH; LUCA.
DR   GeneTree; ENSGT00760000118821; -.
DR   HOGENOM; HOG000231335; -.
DR   HOVERGEN; HBG051707; -.
DR   Reactome; R-DRE-975298; Ligand-gated ion channel transport.
DR   Reactome; R-DRE-977442; GABA A (rho) receptor activation.
DR   Proteomes; UP000000437; Chromosome 17.
DR   Bgee; ENSDARG00000052982; -.
DR   GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR   GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   TIGRFAMs; TIGR00860; LIC; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   2: Evidence at transcript level;
KW   Cell junction {ECO:0000256|SAAS:SAAS00079126};
KW   Cell membrane {ECO:0000256|SAAS:SAAS00079054};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00432391};
KW   Ion channel {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457629};
KW   Ion transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457629};
KW   Membrane {ECO:0000256|SAAS:SAAS00079054,
KW   ECO:0000256|SAAS:SAAS00081645, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Synapse {ECO:0000256|SAAS:SAAS00079126};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00081645,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00081645,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457629}.
FT   TRANSMEM    162    183       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    195    215       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    227    249       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    350    369       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1    161       Neur_chan_LBD.
FT                                {ECO:0000259|Pfam:PF02931}.
FT   DOMAIN      169    285       Neur_chan_memb.
FT                                {ECO:0000259|Pfam:PF02932}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT         1    161       ipfam:Neur_chan_LBD [T]
FT   MYHIT        79     93       ipat:NEUROTR_ION_CHANNEL [T]
FT   MYHIT       169    285       ipfam:Neur_chan_memb [T]
SQ   SEQUENCE   371 AA;  43295 MW;  730E3217001C3ECC CRC64;
     MTLYLRHYWK DERLSFTSST NKSMTFDGRL VKKIWVPDVF FVHSKRSFIH DTTTENIMLR
     VFPDGHVLYS LRVTVTAACN MDFSRFPLDS QTCSLELESY AYTDEDLMLY WKNGDESLSI
     DEKISLSQFL IQKFHTTSRL AFYSSTGWYN RLYINFTLRR HIFFFLLQTY FPATLMVMLS
     WVSFWIDRRA VPARVSLGIT TVLTMSTIIT GVNASMPRVS YIKAVDIYLW VSFVFVFLSV
     LEYAAVNYLT TVQERRERKL RDRAVREQSL PCTCGMSHTR TMMLDGTYSE ADTNSLAGYT
     EAPMVHEEVV PEKQEHMVVH LSVSSESTNT KKKGIRALRI MQNTHAIDKY SRMIFPGAYI
     IFNLIYWSVY C
//