Entry euk:Q08BL9_DANRE

ID   Q08BL9_DANRE            Unreviewed;       599 AA.
AC   Q08BL9;
DT   31-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2006, sequence version 1.
DT   10-MAY-2017, entry version 89.
DE   SubName: Full=Kelch-like family member 24a {ECO:0000313|Ensembl:ENSDARP00000088904};
DE   SubName: Full=Zgc:153342 {ECO:0000313|EMBL:AAI24661.1};
GN   Name=klhl24a {ECO:0000313|Ensembl:ENSDARP00000088904,
GN   ECO:0000313|ZFIN:ZDB-GENE-061013-572};
GN   Synonyms=klhl24 {ECO:0000313|ZFIN:ZDB-GENE-061013-572},
GN   zgc:153342 {ECO:0000313|EMBL:AAI24661.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI24661.1};
RN   [1] {ECO:0000313|EMBL:AAI24661.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary {ECO:0000313|EMBL:AAI24661.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000088904}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000088904};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000088904, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000088904,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
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DR   EMBL; BX323035; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU927915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC124660; AAI24661.1; -; mRNA.
DR   RefSeq; NP_001070808.1; NM_001077340.1.
DR   UniGene; Dr.85961; -.
DR   STRING; 7955.ENSDARP00000088904; -.
DR   Ensembl; ENSDART00000098132; ENSDARP00000088904; ENSDARG00000021739.
DR   GeneID; 768198; -.
DR   KEGG; dre:768198; -.
DR   CTD; 768198; -.
DR   ZFIN; ZDB-GENE-061013-572; klhl24a.
DR   eggNOG; KOG4441; Eukaryota.
DR   eggNOG; ENOG410XNX8; LUCA.
DR   GeneTree; ENSGT00870000136377; -.
DR   HOGENOM; HOG000230817; -.
DR   HOVERGEN; HBG108068; -.
DR   KO; K10461; -.
DR   OMA; RINSSYV; -.
DR   OrthoDB; EOG091G037V; -.
DR   TreeFam; TF351654; -.
DR   Proteomes; UP000000437; Chromosome 2.
DR   Bgee; ENSDARG00000021739; -.
DR   GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:GOC.
DR   GO; GO:2000312; P:regulation of kainate selective glutamate receptor activity; IEA:InterPro.
DR   Gene3D; 2.120.10.80; -; 2.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR030596; KLHL24.
DR   InterPro; IPR011333; SKP1/BTB/POZ.
DR   PANTHER; PTHR24412:SF298; PTHR24412:SF298; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 4.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 6.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Kelch repeat {ECO:0000256|SAAS:SAAS00752720};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Repeat {ECO:0000256|SAAS:SAAS00752774}.
FT   DOMAIN       65    132       BTB (POZ). {ECO:0000259|PROSITE:PS50097}.
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CC   The following FT lines are automated annotations from the MyHits database.
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FT   MYHIT       363    406       ismart:Kelch [T]
FT   MYHIT       454    501       ismart:Kelch [T]
FT   MYHIT       444    485       ipfam:Kelch_1 [T]
FT   MYHIT       494    524       ipfam:Kelch_1 [T]
FT   MYHIT       399    439       ipfam:Kelch_1 [T]
FT   MYHIT        65    162       ismart:BTB [T]
FT   MYHIT       502    543       ismart:Kelch [T]
FT   MYHIT        55    161       ipfam:BTB [T]
FT   MYHIT       407    453       ismart:Kelch [T]
FT   MYHIT       167    269       ismart:BACK [T]
FT   MYHIT       544    591       ismart:Kelch [T]
FT   MYHIT       167    269       ipfam:BACK [T]
FT   MYHIT        65    132       iprf:BTB [T]
FT   MYHIT       312    346       ipfam:Kelch_1 [T]
FT   MYHIT       313    362       ismart:Kelch [T]
SQ   SEQUENCE   599 AA;  67865 MW;  44E72086E9E8B640 CRC64;
     MVLILGRRLN HENSGGVPES PAIKRKVFEM ETKTLSDVFN FSSGSSHSES VLQVFNEFRD
     SRLFTDVIIS VQGREFPCHR AVLSACSSYF RAMFCNDHRE SREMVVEING IQADAMDTFL
     QYVYTGRACI TTLNVQFLFE TSSLFQITTL RDACAKFLEE QLDPCNCLGI QRFADAHSLK
     QLASRCRTFA LLNFPEVAQH EEFQDLRKDE LEEYLASDEL SICREEVVFE AVMRWVYHGV
     EYRRPMLKDL LQHVRLPLLH PNYFVQTVEG DKLIQNAPEC YQLLHEARRY HVLGNEMMSP
     RTRPRRSTGF SEVIVVVGGC ERMGGFNLPY TECYDPVTGE WTSLAKHPEY TKSEYAVCAL
     RNDIILSGGR INSSYVWMYN SQLNVWIRVA SLNKGRWRHK MTVLLGKVYA VGGYDGQCYL
     NNVEVYDSFS NRWTEVAPLK EAVCSPAVTS CAGKLFVIGG EPDENSCSNK VQCYDPESDS
     WQLKACLPFT KPNISAVSLN HLIYVCGGLT KSIYCYDPSQ DHWMHVGHTF SRQESCGVSV
     CNGKIYILGG RGENGEASNN VVCYDPSSGI ITSTAAMPRP VSYHGCVTVH RFSEKQHKP
//