ID OR7G2_HUMAN Reviewed; 324 AA.
AC Q8NG99; Q6IFJ4; Q96RA0;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 10-MAY-2017, entry version 118.
DE RecName: Full=Olfactory receptor 7G2;
DE AltName: Full=OST260;
DE AltName: Full=Olfactory receptor 19-13;
DE Short=OR19-13;
DE AltName: Full=Olfactory receptor OR19-6;
GN Name=OR7G2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=DAA04666.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
CC (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR7G2";
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DR EMBL; AB065927; BAC06142.1; -; Genomic_DNA.
DR EMBL; AC011464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF399539; AAK95024.1; -; Genomic_DNA.
DR EMBL; BK004268; DAA04666.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_001005193.1; NM_001005193.1.
DR UniGene; Hs.553774; -.
DR ProteinModelPortal; Q8NG99; -.
DR STRING; 9606.ENSP00000303822; -.
DR BioMuta; OR7G2; -.
DR DMDM; 38372649; -.
DR PaxDb; Q8NG99; -.
DR PRIDE; Q8NG99; -.
DR Ensembl; ENST00000305456; ENSP00000303822; ENSG00000170923.
DR GeneID; 390882; -.
DR KEGG; hsa:390882; -.
DR UCSC; uc010xkk.2; human.
DR CTD; 390882; -.
DR GeneCards; OR7G2; -.
DR HGNC; HGNC:8466; OR7G2.
DR neXtProt; NX_Q8NG99; -.
DR eggNOG; ENOG410IVB1; Eukaryota.
DR eggNOG; ENOG410YBQN; LUCA.
DR HOGENOM; HOG000041364; -.
DR HOVERGEN; HBG017625; -.
DR InParanoid; Q8NG99; -.
DR KO; K04257; -.
DR OrthoDB; EOG091G0B53; -.
DR PhylomeDB; Q8NG99; -.
DR TreeFam; TF337210; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR GeneWiki; OR7G2; -.
DR GenomeRNAi; 390882; -.
DR PRO; PR:Q8NG99; -.
DR Proteomes; UP000005640; Chromosome 19.
DR CleanEx; HS_OR7G2; -.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Complete proteome; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
KW Polymorphism; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1 324 Olfactory receptor 7G2.
FT /FTId=PRO_0000150651.
FT TOPO_DOM 1 25 Extracellular. {ECO:0000255}.
FT TRANSMEM 26 46 Helical; Name=1. {ECO:0000255}.
FT TOPO_DOM 47 54 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 55 75 Helical; Name=2. {ECO:0000255}.
FT TOPO_DOM 76 99 Extracellular. {ECO:0000255}.
FT TRANSMEM 100 120 Helical; Name=3. {ECO:0000255}.
FT TOPO_DOM 121 139 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 140 160 Helical; Name=4. {ECO:0000255}.
FT TOPO_DOM 161 197 Extracellular. {ECO:0000255}.
FT TRANSMEM 198 217 Helical; Name=5. {ECO:0000255}.
FT TOPO_DOM 218 237 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 238 258 Helical; Name=6. {ECO:0000255}.
FT TOPO_DOM 259 271 Extracellular. {ECO:0000255}.
FT TRANSMEM 272 292 Helical; Name=7. {ECO:0000255}.
FT TOPO_DOM 293 324 Cytoplasmic. {ECO:0000255}.
FT CARBOHYD 5 5 N-linked (GlcNAc...) asparagine.
FT {ECO:0000255}.
FT CARBOHYD 89 89 N-linked (GlcNAc...) asparagine.
FT {ECO:0000255}.
FT DISULFID 97 189 {ECO:0000255|PROSITE-ProRule:PRU00521}.
FT VARIANT 281 281 F -> V (in dbSNP:rs4804401).
FT /FTId=VAR_024113.
FT CONFLICT 271 271 T -> A (in Ref. 3; AAK95024).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 41 290 iprf:G_PROTEIN_RECEP_F1_2 [T]
FT MYHIT 110 126 ipat:G_PROTEIN_RECEP_F1_1 [T]
SQ SEQUENCE 324 AA; 35931 MW; C08808B72ABE34FC CRC64;
MEARNQTAIS KFLLLGLIED PELQPVLFSL FLSMYLVTIL GNLLILLAVI SDSHLHTPMY
FFLSNLSFLD ICLSTTTIPK MLVNIQAQNR SITYSGCLTQ ICFVLFFAGL ENCLLAAMAY
DRYVAICHPL RYTVIMNPRL CGLLILLSLL TSVVNALLLS LMVLRLSFCT DLEIPLFFCE
LAQVIQLTCS DTLINNILIY FAACIFGGVP LSGIILSYTQ ITSCVLRMPS ASGKHKAVST
CGSHLSIVLL FYGAGLGVYI SSVVTDSPRK TAVASVMYSV FPQMVNPFIY SLRNKDMKGT
LRKFIGRIPS LLWCAICFGF RFLE
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