Legends: 1, N-linked (GlcNAc...) asparagine. {ECO:0000255}; 2, VARIANT A -> E (in dbSNP:rs4241472); 3, VARIANT S -> L (in dbSNP:rs2173236); 4, VARIANT S -> W (in dbSNP:rs2173236); 5, VARIANT A -> P (in dbSNP:rs9289564); 6, VARIANT S -> L (in dbSNP:rs16846784); 7, VARIANT C -> R (in dbSNP:rs9853887); 8, VARIANT T -> A (in dbSNP:rs9853906); 9, VARIANT D -> N (in dbSNP:rs9871143); 10, TOPO_DOM Extracellular. {ECO:0000255}; 11, TRANSMEM Helical; Name=1. {ECO:0000255}; 12, TOPO_DOM Cytoplasmic. {ECO:0000255}; 13, TRANSMEM Helical; Name=2. {ECO:0000255}; 14, TRANSMEM Helical; Name=3. {ECO:0000255}; 15, TRANSMEM Helical; Name=4. {ECO:0000255}; 16, TRANSMEM Helical; Name=5. {ECO:0000255}; 17, TRANSMEM Helical; Name=6. {ECO:0000255}; 18, TRANSMEM Helical; Name=7. {ECO:0000255}; 19, ipat:G_PROTEIN_RECEP_F1_1 [T].
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ID OR5H6_HUMAN Reviewed; 325 AA.
AC Q8NGV6; Q6IF88;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 10-MAY-2017, entry version 123.
DE RecName: Full=Olfactory receptor 5H6;
DE AltName: Full=Olfactory receptor OR3-11;
GN Name=OR5H6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-17 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05893.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
CC (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5H6";
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DR EMBL; AB065667; BAC05893.1; ALT_INIT; Genomic_DNA.
DR EMBL; BC137523; AAI37524.1; -; mRNA.
DR EMBL; BC137524; AAI37525.1; -; mRNA.
DR EMBL; BK004374; DAA04772.1; -; Genomic_DNA.
DR CCDS; CCDS33800.1; -.
DR RefSeq; NP_001005479.1; NM_001005479.1.
DR RefSeq; XP_011511420.1; XM_011513118.2.
DR UniGene; Hs.554712; -.
DR ProteinModelPortal; Q8NGV6; -.
DR IntAct; Q8NGV6; 1.
DR STRING; 9606.ENSP00000373196; -.
DR iPTMnet; Q8NGV6; -.
DR PhosphoSitePlus; Q8NGV6; -.
DR BioMuta; OR5H6; -.
DR DMDM; 223590117; -.
DR PaxDb; Q8NGV6; -.
DR PeptideAtlas; Q8NGV6; -.
DR PRIDE; Q8NGV6; -.
DR Ensembl; ENST00000383696; ENSP00000373196; ENSG00000230301.
DR GeneID; 79295; -.
DR KEGG; hsa:79295; -.
DR UCSC; uc003dsi.1; human.
DR CTD; 79295; -.
DR DisGeNET; 79295; -.
DR GeneCards; OR5H6; -.
DR H-InvDB; HIX0200564; -.
DR HGNC; HGNC:14767; OR5H6.
DR neXtProt; NX_Q8NGV6; -.
DR PharmGKB; PA32537; -.
DR eggNOG; ENOG410J97S; Eukaryota.
DR eggNOG; ENOG4111537; LUCA.
DR GeneTree; ENSGT00550000074564; -.
DR HOGENOM; HOG000041364; -.
DR HOVERGEN; HBG017625; -.
DR InParanoid; Q8NGV6; -.
DR KO; K04257; -.
DR OMA; TCSEEME; -.
DR OrthoDB; EOG091G0C7C; -.
DR PhylomeDB; Q8NGV6; -.
DR TreeFam; TF352737; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR GeneWiki; OR5H6; -.
DR GenomeRNAi; 79295; -.
DR PRO; PR:Q8NGV6; -.
DR Proteomes; UP000005640; Chromosome 3.
DR CleanEx; HS_OR5H6; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Complete proteome; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
KW Polymorphism; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1 325 Olfactory receptor 5H6.
FT /FTId=PRO_0000150597.
FT TOPO_DOM 1 41 Extracellular. {ECO:0000255}.
FT TRANSMEM 42 62 Helical; Name=1. {ECO:0000255}.
FT TOPO_DOM 63 70 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 71 91 Helical; Name=2. {ECO:0000255}.
FT TOPO_DOM 92 115 Extracellular. {ECO:0000255}.
FT TRANSMEM 116 136 Helical; Name=3. {ECO:0000255}.
FT TOPO_DOM 137 155 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 156 176 Helical; Name=4. {ECO:0000255}.
FT TOPO_DOM 177 212 Extracellular. {ECO:0000255}.
FT TRANSMEM 213 233 Helical; Name=5. {ECO:0000255}.
FT TOPO_DOM 234 253 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 254 274 Helical; Name=6. {ECO:0000255}.
FT TOPO_DOM 275 287 Extracellular. {ECO:0000255}.
FT TRANSMEM 288 308 Helical; Name=7. {ECO:0000255}.
FT TOPO_DOM 309 325 Cytoplasmic. {ECO:0000255}.
FT CARBOHYD 21 21 N-linked (GlcNAc...) asparagine.
FT {ECO:0000255}.
FT DISULFID 113 205 {ECO:0000255|PROSITE-ProRule:PRU00521}.
FT VARIANT 46 46 A -> E (in dbSNP:rs4241472).
FT /FTId=VAR_054343.
FT VARIANT 88 88 S -> L (in dbSNP:rs2173236).
FT /FTId=VAR_060008.
FT VARIANT 88 88 S -> W (in dbSNP:rs2173236).
FT /FTId=VAR_060009.
FT VARIANT 145 145 A -> P (in dbSNP:rs9289564).
FT /FTId=VAR_054344.
FT VARIANT 179 179 S -> L (in dbSNP:rs16846784).
FT /FTId=VAR_054345.
FT VARIANT 195 195 C -> R (in dbSNP:rs9853887).
FT /FTId=VAR_054346.
FT VARIANT 272 272 T -> A (in dbSNP:rs9853906).
FT /FTId=VAR_054347.
FT VARIANT 285 285 D -> N (in dbSNP:rs9871143).
FT /FTId=VAR_054348.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 57 306 iprf:G_PROTEIN_RECEP_F1_2 [T]
FT MYHIT 126 142 ipat:G_PROTEIN_RECEP_F1_1 [T]
SQ SEQUENCE 325 AA; 36713 MW; E54F8A835C903407 CRC64;
MFLYLCFIFQ RTCSEEMEEE NATLLTEFVL TGFLHQPDCK IPLFLAFLVI YLITIMGNLG
LIVLIWKDPH LHIPMYLFLG SLAFVDASLS STVTPKMLIN FLAKSKMISL SECMVQFFSL
VTTVTTECFL LATMAYDRYV AICKALLYPV IMTNELCIQL LVLSFIGGLL HALIHEAFSF
RLTFCNSNII QHFYCDIIPL LKISCTDSSI NFLMVFIFAG SVQVFTIGTI LISYTIILFT
ILEKKSIKGI RKAVSTCGAH LLSVSLYYGP LTFKYLGSAS PQADDQDMME SLFYTVIVPL
LNPMIYSLRN KQVIASFTKM FKSNV
//
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