ID OR2M2_HUMAN Reviewed; 347 AA.
AC Q96R28; A3KFT4;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 10-MAY-2017, entry version 123.
DE RecName: Full=Olfactory receptor 2M2;
DE AltName: Full=OST423;
GN Name=OR2M2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
CC (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2M2";
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DR EMBL; AL592313; CAM45730.1; -; Genomic_DNA.
DR EMBL; AF399616; AAK95101.1; -; Genomic_DNA.
DR CCDS; CCDS31106.1; -.
DR RefSeq; NP_001004688.1; NM_001004688.1.
DR UniGene; Hs.534728; -.
DR ProteinModelPortal; Q96R28; -.
DR SMR; Q96R28; -.
DR STRING; 9606.ENSP00000352710; -.
DR iPTMnet; Q96R28; -.
DR PhosphoSitePlus; Q96R28; -.
DR BioMuta; OR2M2; -.
DR DMDM; 85541044; -.
DR PaxDb; Q96R28; -.
DR PRIDE; Q96R28; -.
DR Ensembl; ENST00000359682; ENSP00000352710; ENSG00000198601.
DR GeneID; 391194; -.
DR KEGG; hsa:391194; -.
DR UCSC; uc010pzf.2; human.
DR CTD; 391194; -.
DR GeneCards; OR2M2; -.
DR H-InvDB; HIX0028950; -.
DR HGNC; HGNC:8268; OR2M2.
DR neXtProt; NX_Q96R28; -.
DR PharmGKB; PA32192; -.
DR eggNOG; ENOG410IKZY; Eukaryota.
DR eggNOG; ENOG41115SC; LUCA.
DR GeneTree; ENSGT00760000118850; -.
DR HOGENOM; HOG000041365; -.
DR HOVERGEN; HBG017625; -.
DR InParanoid; Q96R28; -.
DR KO; K04257; -.
DR OMA; ICGLMAT; -.
DR OrthoDB; EOG091G0CY3; -.
DR PhylomeDB; Q96R28; -.
DR TreeFam; TF337295; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR GeneWiki; OR2M2; -.
DR GenomeRNAi; 391194; -.
DR PRO; PR:Q96R28; -.
DR Proteomes; UP000005640; Chromosome 1.
DR CleanEx; HS_OR2M2; -.
DR ExpressionAtlas; Q96R28; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Complete proteome; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
KW Polymorphism; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1 347 Olfactory receptor 2M2.
FT /FTId=PRO_0000150491.
FT TOPO_DOM 1 25 Extracellular. {ECO:0000255}.
FT TRANSMEM 26 49 Helical; Name=1. {ECO:0000255}.
FT TOPO_DOM 50 57 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 58 79 Helical; Name=2. {ECO:0000255}.
FT TOPO_DOM 80 100 Extracellular. {ECO:0000255}.
FT TRANSMEM 101 120 Helical; Name=3. {ECO:0000255}.
FT TOPO_DOM 121 139 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 140 158 Helical; Name=4. {ECO:0000255}.
FT TOPO_DOM 159 195 Extracellular. {ECO:0000255}.
FT TRANSMEM 196 219 Helical; Name=5. {ECO:0000255}.
FT TOPO_DOM 220 236 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 237 259 Helical; Name=6. {ECO:0000255}.
FT TOPO_DOM 260 272 Extracellular. {ECO:0000255}.
FT TRANSMEM 273 292 Helical; Name=7. {ECO:0000255}.
FT TOPO_DOM 293 347 Cytoplasmic. {ECO:0000255}.
FT CARBOHYD 5 5 N-linked (GlcNAc...) asparagine.
FT {ECO:0000255}.
FT CARBOHYD 190 190 N-linked (GlcNAc...) asparagine.
FT {ECO:0000255}.
FT DISULFID 97 189 {ECO:0000255|PROSITE-ProRule:PRU00521}.
FT VARIANT 87 87 S -> C (in dbSNP:rs61156873).
FT /FTId=VAR_062026.
FT VARIANT 220 220 R -> G (in dbSNP:rs4244171).
FT /FTId=VAR_059990.
FT VARIANT 235 235 C -> R (in dbSNP:rs4916104).
FT /FTId=VAR_059991.
FT VARIANT 237 237 A -> T (in dbSNP:rs9435890).
FT /FTId=VAR_034179.
FT CONFLICT 72 72 M -> K (in Ref. 2; AAK95101).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 110 126 ipat:G_PROTEIN_RECEP_F1_1 [T]
FT MYHIT 41 290 iprf:G_PROTEIN_RECEP_F1_2 [T]
FT MYHIT 35 305 ismart:7TM_GPCR_Srsx [T]
SQ SEQUENCE 347 AA; 39177 MW; 3432AA0B3EC8F474 CRC64;
MAWENQTFNS DFILLGIFNH SPPHTFLFFL VLGIFLVAFM GNSVMVLLIY LDTQLHTPMY
FLLSQLSLMD LMLICTTVPK MAFNYLSGSK SISMAGCVTQ IFFYISLSGS ECFLLAVMAY
DRYIAICHPL RYTNLMNPKI CGLMATFSWI LGSTDGIIDA VATFSFSFCG SREIAHFFCE
FPSLLILSCN DTSIFEEVIF ICCIVMLVFP VAIIIASYAR VILAVIHMGS GEGRCKAFTT
CSSHLMVVGM YYGAALFMYI RPTSDHSPTQ DKMVSVFYTI LTPMLNPLIY SLRNKEVTRA
FMKILGKGKS ESELPHKLYV LLFAKFFFLI SIFFYDVKIL ALIMYIA
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