Entry euk:O13C3_HUMAN

ID   O13C3_HUMAN             Reviewed;         347 AA.
AC   Q8NGS6; Q5VVG1; Q6IF52;
DT   26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   10-MAY-2017, entry version 131.
DE   RecName: Full=Olfactory receptor 13C3;
DE   AltName: Full=Olfactory receptor OR9-8;
GN   Name=OR13C3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA   Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA   Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA   Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA   Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA   Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA   Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA   Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA   Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA   Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA   Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA   McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA   Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA   Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA   Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA   Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA   Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA   Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA   Rogers J., Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [5]
RP   ERRATUM.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-31 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC05934.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAH72411.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
CC       (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR13C3";
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AB065713; BAC05934.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL450426; CAH72411.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BC136949; AAI36950.1; -; mRNA.
DR   EMBL; BC136952; AAI36953.1; -; mRNA.
DR   EMBL; BK004410; DAA04808.1; -; Genomic_DNA.
DR   CCDS; CCDS35089.1; -.
DR   RefSeq; NP_001001961.1; NM_001001961.1.
DR   UniGene; Hs.553600; -.
DR   ProteinModelPortal; Q8NGS6; -.
DR   STRING; 9606.ENSP00000363913; -.
DR   iPTMnet; Q8NGS6; -.
DR   PhosphoSitePlus; Q8NGS6; -.
DR   BioMuta; OR13C3; -.
DR   DMDM; 218511724; -.
DR   PaxDb; Q8NGS6; -.
DR   PRIDE; Q8NGS6; -.
DR   Ensembl; ENST00000374781; ENSP00000363913; ENSG00000204246.
DR   GeneID; 138803; -.
DR   KEGG; hsa:138803; -.
DR   UCSC; uc004bcb.2; human.
DR   CTD; 138803; -.
DR   DisGeNET; 138803; -.
DR   GeneCards; OR13C3; -.
DR   HGNC; HGNC:14704; OR13C3.
DR   HPA; HPA053978; -.
DR   neXtProt; NX_Q8NGS6; -.
DR   PharmGKB; PA32033; -.
DR   eggNOG; ENOG410IENR; Eukaryota.
DR   eggNOG; ENOG4111CQX; LUCA.
DR   GeneTree; ENSGT00760000119058; -.
DR   HOGENOM; HOG000041365; -.
DR   HOVERGEN; HBG017625; -.
DR   InParanoid; Q8NGS6; -.
DR   KO; K04257; -.
DR   OMA; IEIVYFA; -.
DR   OrthoDB; EOG091G0CU6; -.
DR   PhylomeDB; Q8NGS6; -.
DR   TreeFam; TF352686; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   GeneWiki; OR13C3; -.
DR   GenomeRNAi; 138803; -.
DR   PRO; PR:Q8NGS6; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   Bgee; ENSG00000204246; -.
DR   CleanEx; HS_OR13C3; -.
DR   ExpressionAtlas; Q8NGS6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Complete proteome; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
KW   Polymorphism; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN         1    347       Olfactory receptor 13C3.
FT                                /FTId=PRO_0000150732.
FT   TOPO_DOM      1     55       Extracellular. {ECO:0000255}.
FT   TRANSMEM     56     76       Helical; Name=1. {ECO:0000255}.
FT   TOPO_DOM     77     84       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     85    105       Helical; Name=2. {ECO:0000255}.
FT   TOPO_DOM    106    129       Extracellular. {ECO:0000255}.
FT   TRANSMEM    130    150       Helical; Name=3. {ECO:0000255}.
FT   TOPO_DOM    151    169       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    170    190       Helical; Name=4. {ECO:0000255}.
FT   TOPO_DOM    191    227       Extracellular. {ECO:0000255}.
FT   TRANSMEM    228    247       Helical; Name=5. {ECO:0000255}.
FT   TOPO_DOM    248    267       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    268    288       Helical; Name=6. {ECO:0000255}.
FT   TOPO_DOM    289    307       Extracellular. {ECO:0000255}.
FT   TRANSMEM    308    328       Helical; Name=7. {ECO:0000255}.
FT   TOPO_DOM    329    347       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD     35     35       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    127    219       {ECO:0000255|PROSITE-ProRule:PRU00521}.
FT   VARIANT     293    293       K -> T (in dbSNP:rs10512330).
FT                                /FTId=VAR_024131.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT        71    326       iprf:G_PROTEIN_RECEP_F1_2 [T]
FT   MYHIT       140    156       ipat:G_PROTEIN_RECEP_F1_1 [T]
SQ   SEQUENCE   347 AA;  38729 MW;  6318EA2A850871D7 CRC64;
     MIVQLICTVC FLAVNTFHVR SSFDFLKADD MGEINQTLVS EFLLLGLSGY PKIEIVYFAL
     ILVMYLVILI GNGVLIIASI FDSHFHTPMY FFLGNLSFLD ICYTSSSVPS TLVSLISKKR
     NISFSGCAVQ MFFGFAMGST ECLLLGMMAF DRYVAICNPL RYPIILSKVA YVLMASVSWL
     SGGINSAVQT LLAMRLPFCG NNIINHFACE ILAVLKLACA DISLNIITMV ISNMAFLVLP
     LMVIFFSYMF ILYTILQMNS ATGRRKAFST CSAHLTVVII FYGTIFFMYA KPKSQDLIGE
     EKLQALDKLI SLFYGVVTPM LNPILYSLRN KDVKAAVKYL LNKKPIH
//