ID NU5M_DROME Reviewed; 572 AA.
AC P18932; Q36735; Q9MGN9; Q9MJC7;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 27-JAN-2003, sequence version 4.
DT 12-APR-2017, entry version 122.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5;
DE EC=1.6.5.3;
DE AltName: Full=NADH dehydrogenase subunit 5;
GN Name=mt:ND5; Synonyms=NADH5, ND5;
OS Drosophila melanogaster (Fruit fly).
OG Mitochondrion.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Bretagne;
RX PubMed=3130291;
RA Garesse R.;
RT "Drosophila melanogaster mitochondrial DNA: gene organization and
RT evolutionary considerations.";
RL Genetics 118:649-663(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Oregon-R, and Zimbabwe 53;
RX PubMed=10903372; DOI=10.1007/s002390010066;
RA Ballard J.W.O.;
RT "Comparative genomics of mitochondrial DNA in members of the
RT Drosophila melanogaster subgroup.";
RL J. Mol. Evol. 51:48-63(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Paris;
RX PubMed=11298822; DOI=10.1046/j.1365-2540.2001.00814.x;
RA Azou Y., Bregliano J.C.;
RT "I-R system of hybrid dysgenesis in Drosophila melanogaster: analysis
RT of the mitochondrial DNA in reactive strains exhibiting different
RT potentials for I factor transposition.";
RL Heredity 86:110-116(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=8825764; DOI=10.1111/j.1365-2583.1995.tb00032.x;
RA Lewis D.L., Farr C.L., Kaguni L.S.;
RT "Drosophila melanogaster mitochondrial DNA: completion of the
RT nucleotide sequence and evolutionary comparisons.";
RL Insect Mol. Biol. 4:263-278(1995).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RA Wan K., Celniker S.;
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-510.
RX PubMed=7851771;
RA Rand D.M., Dorfsman M., Kann L.M.;
RT "Neutral and non-neutral evolution of Drosophila mitochondrial DNA.";
RL Genetics 138:741-756(1994).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I) that is believed to belong to
CC the minimal assembly required for catalysis. Complex I functions
CC in the transfer of electrons from NADH to the respiratory chain.
CC The immediate electron acceptor for the enzyme is believed to be
CC ubiquinone (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY: NADH + ubiquinone + 5 H(+)(In) = NAD(+) +
CC ubiquinol + 4 H(+)(Out).
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB91058.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; M37275; AAA69710.1; ALT_TERM; Genomic_DNA.
DR EMBL; AF200828; AAF77233.1; -; Genomic_DNA.
DR EMBL; AF200829; AAF77251.1; -; Genomic_DNA.
DR EMBL; AJ400907; CAB91058.1; ALT_INIT; Genomic_DNA.
DR EMBL; U37541; AAC47818.1; -; Genomic_DNA.
DR EMBL; KJ947872; AIC64011.1; -; Genomic_DNA.
DR EMBL; S76764; AAB33356.1; -; Genomic_DNA.
DR PIR; S01186; S01186.
DR RefSeq; YP_009047273.1; NC_024511.2.
DR ProteinModelPortal; P18932; -.
DR STRING; 7227.FBpp0100182; -.
DR PaxDb; P18932; -.
DR PRIDE; P18932; -.
DR GeneID; 19893549; -.
DR KEGG; dme:ND5; -.
DR CTD; 4540; -.
DR FlyBase; FBgn0013684; mt:ND5.
DR eggNOG; KOG4668; Eukaryota.
DR eggNOG; COG1009; LUCA.
DR InParanoid; P18932; -.
DR KO; K03883; -.
DR OrthoDB; EOG091G0M2F; -.
DR PhylomeDB; P18932; -.
DR ChiTaRS; mt:ND5; fly.
DR GenomeRNAi; 19893549; -.
DR PRO; PR:P18932; -.
DR Proteomes; UP000000803; Mitochondrion.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR001516; Proton_antipo_N.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01435; NPOXDRDTASE5.
PE 3: Inferred from homology;
KW Complete proteome; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; NAD; Oxidoreductase; Reference proteome;
KW Respiratory chain; Transmembrane; Transmembrane helix; Transport;
KW Ubiquinone.
FT CHAIN 1 572 NADH-ubiquinone oxidoreductase chain 5.
FT /FTId=PRO_0000118090.
FT TRANSMEM 4 24 Helical. {ECO:0000255}.
FT TRANSMEM 44 64 Helical. {ECO:0000255}.
FT TRANSMEM 86 106 Helical. {ECO:0000255}.
FT TRANSMEM 107 127 Helical. {ECO:0000255}.
FT TRANSMEM 147 167 Helical. {ECO:0000255}.
FT TRANSMEM 170 190 Helical. {ECO:0000255}.
FT TRANSMEM 217 237 Helical. {ECO:0000255}.
FT TRANSMEM 239 259 Helical. {ECO:0000255}.
FT TRANSMEM 268 288 Helical. {ECO:0000255}.
FT TRANSMEM 294 314 Helical. {ECO:0000255}.
FT TRANSMEM 337 357 Helical. {ECO:0000255}.
FT TRANSMEM 372 394 Helical. {ECO:0000255}.
FT TRANSMEM 422 442 Helical. {ECO:0000255}.
FT TRANSMEM 457 477 Helical. {ECO:0000255}.
FT TRANSMEM 490 510 Helical. {ECO:0000255}.
FT TRANSMEM 552 572 Helical. {ECO:0000255}.
FT CONFLICT 331 331 I -> IGI (in Ref. 1; AAA69710/AAC47818).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 389 569 ipfam:NADH5_C [T]
FT MYHIT 34 88 ipfam:Proton_antipo_N [T]
FT MYHIT 102 385 ipfam:Proton_antipo_M [T]
SQ SEQUENCE 572 AA; 65145 MW; 8BFEEF4CE24B5575 CRC64;
MCSISFVNLI SMSLSCFLLS LYFLLNDMIY FIEWELVSLN SMSIVMTFLF DWMSLLFMSF
VLMISSLVIF YSKEYMMNDN HINRFIMLVL MFVLSMMLLI ISPNLISILL GWDGLGLVSY
CLVIYFQNIK SYNAGMLTAL SNRIGDVALL LSIAWMLNYG SWNYIFYLEI MQNEFEMLMI
GSLVMLAAMT KSAQIPFSSW LPAAMAAPTP VSALVHSSTL VTAGVYLLIR FNIILSTSWL
GQLMLLLSGL TMFMAGLGAN FEFDLKKIIA LSTLSQLGLM MSILSMGFLK LAMFHLLTHA
LFKALLFMCA GAIIHNMNNS QDIRLMGGLS IHMPLTSACF NVSNLALCGM PFLAGFYSKD
MILEIVSISN VNMFSFFLYY FSTGLTVSYS FRLVYYSMTG DLNCGSLNML NDESWIMLRG
MMGLLIMSII GGSMLNWLIF PFPYMICLPI YMKLLTLFVC IVGGLFGYLI SLSNLFFLNK
SLFMYNLSTF LGSMWFMPYI STYGMIFYPL NYGQLVVKSF DQGWSEYFGG QHLYQKLSMY
SKTLFLMHNN SLKIYLLLFV FWILILLILL FL
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