Entry euk:NBDY_HUMAN

ID   NBDY_HUMAN              Reviewed;          68 AA.
AC   A0A0U1RRE5;
DT   15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT   17-FEB-2016, sequence version 1.
DT   10-MAY-2017, entry version 9.
DE   RecName: Full=Negative regulator of P-body association {ECO:0000312|HGNC:HGNC:50713};
DE   AltName: Full=P-body dissociating protein {ECO:0000303|PubMed:27918561};
DE   AltName: Full=Protein NoBody {ECO:0000303|PubMed:27918561};
GN   Name=NBDY {ECO:0000312|HGNC:HGNC:50713};
GN   Synonyms=LINC01420 {ECO:0000312|HGNC:HGNC:50713};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000312|Ensembl:ENSP00000489486};
RN   [1] {ECO:0000312|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A.,
RA   Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G.,
RA   Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S.,
RA   Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R.,
RA   Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L.,
RA   Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A.,
RA   Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S.,
RA   Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R.,
RA   Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M.,
RA   Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N.,
RA   Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D.,
RA   Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W.,
RA   Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C.,
RA   Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C.,
RA   Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J.,
RA   Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S.,
RA   Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I.,
RA   Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L.,
RA   Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P.,
RA   Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S.,
RA   Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A.,
RA   Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J.,
RA   Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J.,
RA   Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S.,
RA   de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z.,
RA   Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C.,
RA   Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W.,
RA   Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T.,
RA   Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I.,
RA   Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N.,
RA   Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J.,
RA   Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E.,
RA   Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S.,
RA   Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T.,
RA   Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S.,
RA   Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L.,
RA   Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A.,
RA   Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L.,
RA   Williams G., Williams L., Williamson A., Williamson H., Wilming L.,
RA   Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H.,
RA   Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A.,
RA   Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A.,
RA   Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T.,
RA   Gibbs R.A., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [2] {ECO:0000312|EMBL:EAW93234.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000305}
RP   FUNCTION, INTERACTION WITH DCP1A; DCP2 AND EDC4, SUBCELLULAR LOCATION,
RP   MUTAGENESIS OF LYS-22; PRO-23; PRO-24; LYS-25; LYS-26; ARG-27; CYS-28;
RP   LEU-29; LEU-30; PRO-32; ARG-33; TRP-34; ASP-35; TYR-36; PRO-37;
RP   GLU-38; GLY-39; THR-40 AND PRO-41, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RX   PubMed=27918561; DOI=10.1038/nchembio.2249;
RA   D'Lima N.G., Ma J., Winkler L., Chu Q., Loh K.H., Corpuz E.O.,
RA   Budnik B.A., Lykke-Andersen J., Saghatelian A., Slavoff S.A.;
RT   "A human microprotein that interacts with the mRNA decapping
RT   complex.";
RL   Nat. Chem. Biol. 13:174-180(2017).
CC   -!- FUNCTION: Promotes dispersal of P-body components and is likely to
CC       play a role in the mRNA decapping process.
CC       {ECO:0000269|PubMed:27918561}.
CC   -!- SUBUNIT: Interacts with mRNA decapping proteins DCP1A, DCP2 and
CC       EDC4. {ECO:0000269|PubMed:27918561}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC       {ECO:0000269|PubMed:27918561}. Note=Localizes to P-bodies at low
CC       concentrations without dissociating them.
CC       {ECO:0000269|PubMed:27918561}.
CC   -!- CAUTION: Was previously thought to be non-coding but has been
CC       shown to be translated and functional.
CC       {ECO:0000269|PubMed:27918561}.
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DR   EMBL; AL158200; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL354865; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459114; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471154; EAW93234.1; -; Genomic_DNA.
DR   RefSeq; NP_001335058.1; NM_001348129.1.
DR   UniGene; Hs.355559; -.
DR   ProteinModelPortal; A0A0U1RRE5; -.
DR   SMR; A0A0U1RRE5; -.
DR   MaxQB; A0A0U1RRE5; -.
DR   PeptideAtlas; A0A0U1RRE5; -.
DR   Ensembl; ENST00000374922; ENSP00000489583; ENSG00000204272.
DR   Ensembl; ENST00000423617; ENSP00000489486; ENSG00000204272.
DR   Ensembl; ENST00000637096; ENSP00000490217; ENSG00000204272.
DR   GeneID; 550643; -.
DR   GeneCards; LINC01420; -.
DR   HGNC; HGNC:50713; NBDY.
DR   MIM; 300992; gene.
DR   OpenTargets; ENSG00000204272; -.
DR   GeneTree; ENSGT00390000004891; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   ExpressionAtlas; A0A0U1RRE5; baseline and differential.
DR   GO; GO:0000932; C:P-body; IDA:UniProtKB.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0010607; P:negative regulation of cytoplasmic mRNA processing body assembly; IDA:UniProtKB.
DR   GO; GO:0000956; P:nuclear-transcribed mRNA catabolic process; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Complete proteome; Cytoplasm; mRNA processing; Reference proteome.
FT   CHAIN         1     68       Negative regulator of P-body association.
FT                                /FTId=PRO_0000439205.
FT   SITE         30     30       Required for interaction with EDC4.
FT                                {ECO:0000269|PubMed:27918561}.
FT   SITE         34     34       Required for interaction with EDC4.
FT                                {ECO:0000269|PubMed:27918561}.
FT   MUTAGEN      22     22       K->A: No effect on interaction with EDC4.
FT                                {ECO:0000269|PubMed:27918561}.
FT   MUTAGEN      23     23       P->A: No effect on interaction with EDC4.
FT                                {ECO:0000269|PubMed:27918561}.
FT   MUTAGEN      24     24       P->A: No effect on interaction with EDC4.
FT                                {ECO:0000269|PubMed:27918561}.
FT   MUTAGEN      25     25       K->A: No effect on interaction with EDC4.
FT                                {ECO:0000269|PubMed:27918561}.
FT   MUTAGEN      26     26       K->A: No effect on interaction with EDC4.
FT                                {ECO:0000269|PubMed:27918561}.
FT   MUTAGEN      27     27       R->A: No effect on interaction with EDC4.
FT                                {ECO:0000269|PubMed:27918561}.
FT   MUTAGEN      28     28       C->A: No effect on interaction with EDC4.
FT                                {ECO:0000269|PubMed:27918561}.
FT   MUTAGEN      29     29       L->A: No effect on interaction with EDC4.
FT                                {ECO:0000269|PubMed:27918561}.
FT   MUTAGEN      30     30       L->A: Impaired interaction with EDC4.
FT                                {ECO:0000269|PubMed:27918561}.
FT   MUTAGEN      32     32       P->A: No effect on interaction with EDC4.
FT                                {ECO:0000269|PubMed:27918561}.
FT   MUTAGEN      33     33       R->A: No effect on interaction with EDC4.
FT                                {ECO:0000269|PubMed:27918561}.
FT   MUTAGEN      34     34       W->A: Impaired interaction with EDC4.
FT                                {ECO:0000269|PubMed:27918561}.
FT   MUTAGEN      35     35       D->A: No effect on interaction with EDC4.
FT                                {ECO:0000269|PubMed:27918561}.
FT   MUTAGEN      36     36       Y->A: No effect on interaction with EDC4.
FT                                {ECO:0000269|PubMed:27918561}.
FT   MUTAGEN      37     37       P->A: No effect on interaction with EDC4.
FT                                {ECO:0000269|PubMed:27918561}.
FT   MUTAGEN      38     38       E->A: No effect on interaction with EDC4.
FT                                {ECO:0000269|PubMed:27918561}.
FT   MUTAGEN      39     39       G->A: No effect on interaction with EDC4.
FT                                {ECO:0000269|PubMed:27918561}.
FT   MUTAGEN      40     40       T->A: No effect on interaction with EDC4.
FT                                {ECO:0000269|PubMed:27918561}.
FT   MUTAGEN      41     41       P->A: No effect on interaction with EDC4.
FT                                {ECO:0000269|PubMed:27918561}.
SQ   SEQUENCE   68 AA;  7025 MW;  FA372C7380B65853 CRC64;
     MGDQPCASGR STLPPGNARE AKPPKKRCLL APRWDYPEGT PNGGSTTLPS APPPASAGLK
     SHPPPPEK
//