MyHits has reached its end of life and no longer provides data or services. Thank you for your support and trust for more than 23 years!
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
- MyHits
| Description | RecName: Full=Major sperm protein 19/31/40/45/50/51/53/59/61/65/81/113/142; Short=MSP; |
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| MyHits synonyms | MSP19_CAEEL , P53017 , 69F69631BEA5B147 |
 Legends: 1, INIT_MET Removed. {ECO:0000250}; 2, N-acetylalanine. {ECO:0000250}; 3, STRAND {ECO:0000244|PDB:1GRW}; 4, TURN {ECO:0000244|PDB:1GRW}; 5, HELIX {ECO:0000244|PDB:1GRW}.
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ID MSP19_CAEEL Reviewed; 127 AA.
AC P53017;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 12-APR-2017, entry version 131.
DE RecName: Full=Major sperm protein 19/31/40/45/50/51/53/59/61/65/81/113/142;
DE Short=MSP;
GN Name=msp-19; ORFNames=F36H12.7;
GN and
GN Name=msp-31; ORFNames=R05F9.13;
GN and
GN Name=msp-40; ORFNames=C33F10.9;
GN and
GN Name=msp-45; ORFNames=F58A6.8;
GN and
GN Name=msp-50; ORFNames=C34F11.4;
GN and
GN Name=msp-51; ORFNames=ZK354.5;
GN and
GN Name=msp-53; ORFNames=R13H9.4;
GN and
GN Name=msp-59; ORFNames=ZK354.11;
GN and
GN Name=msp-64; ORFNames=ZK1248.6;
GN and
GN Name=msp-65; ORFNames=ZK354.1;
GN and
GN Name=msp-81; ORFNames=K07F5.1;
GN and
GN Name=msp-113; ORFNames=ZK354.4;
GN and
GN Name=msp-142; ORFNames=K05F1.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for
RT investigating biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS), AND SUBUNIT.
RX PubMed=12051923; DOI=10.1016/S0022-2836(02)00294-2;
RA Baker A.M., Roberts T.M., Stewart M.;
RT "2.6 A resolution crystal structure of helices of the motile major
RT sperm protein (MSP) of Caenorhabditis elegans.";
RL J. Mol. Biol. 319:491-499(2002).
CC -!- FUNCTION: Central component in molecular interactions underlying
CC sperm crawling. Forms an extensive filament system that extends
CC from sperm villipoda, along the leading edge of the pseudopod.
CC -!- SUBUNIT: Helical subfilaments are built from MSP dimers; filaments
CC are formed from two subfilaments coiling round one another; and
CC filaments themselves supercoil to produce bundles.
CC {ECO:0000269|PubMed:12051923}.
CC -!- SUBCELLULAR LOCATION: Cell projection, pseudopodium. Cytoplasm,
CC cytoskeleton.
CC -!- TISSUE SPECIFICITY: Sperm.
CC -!- MISCELLANEOUS: Around 30 MSP isoforms may exist in C.elegans.
CC -----------------------------------------------------------------------
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DR EMBL; FO080275; CCD62525.1; -; Genomic_DNA.
DR EMBL; FO080689; CCD65824.1; -; Genomic_DNA.
DR EMBL; FO080690; CCD65838.1; -; Genomic_DNA.
DR EMBL; FO080763; CCD66514.1; -; Genomic_DNA.
DR EMBL; FO081106; CCD69142.1; -; Genomic_DNA.
DR EMBL; FO081120; CCD69279.1; -; Genomic_DNA.
DR EMBL; FO081309; CCD70664.1; -; Genomic_DNA.
DR EMBL; FO081310; CCD70677.1; -; Genomic_DNA.
DR EMBL; FO081310; CCD70681.1; -; Genomic_DNA.
DR EMBL; FO081310; CCD70682.1; -; Genomic_DNA.
DR EMBL; FO081310; CCD70687.1; -; Genomic_DNA.
DR EMBL; FO081574; CCD72508.1; -; Genomic_DNA.
DR PIR; A88165; A88165.
DR PIR; B88689; B88689.
DR PIR; C88688; C88688.
DR PIR; C88689; C88689.
DR PIR; D88164; D88164.
DR PIR; E88134; E88134.
DR PIR; F88138; F88138.
DR PIR; G88145; G88145.
DR PIR; G88686; G88686.
DR PIR; H88146; H88146.
DR PIR; H88688; H88688.
DR PIR; H88792; H88792.
DR RefSeq; NP_494865.1; NM_062464.6.
DR RefSeq; NP_494898.1; NM_062497.6.
DR RefSeq; NP_494959.1; NM_062558.8.
DR RefSeq; NP_494972.1; NM_062571.8.
DR RefSeq; NP_495144.1; NM_062743.4.
DR RefSeq; NP_495149.1; NM_062748.3.
DR RefSeq; NP_500714.1; NM_068313.5.
DR RefSeq; NP_500760.1; NM_068359.5.
DR RefSeq; NP_500771.1; NM_068370.7.
DR RefSeq; NP_500773.1; NM_068372.6.
DR RefSeq; NP_500778.1; NM_068377.7.
DR RefSeq; NP_500780.1; NM_068379.4.
DR RefSeq; NP_501759.1; NM_069358.4.
DR UniGene; Cel.14684; -.
DR UniGene; Cel.14687; -.
DR UniGene; Cel.14690; -.
DR UniGene; Cel.18187; -.
DR UniGene; Cel.18261; -.
DR UniGene; Cel.21338; -.
DR UniGene; Cel.21355; -.
DR UniGene; Cel.21393; -.
DR UniGene; Cel.21394; -.
DR UniGene; Cel.30510; -.
DR UniGene; Cel.34224; -.
DR UniGene; Cel.34229; -.
DR UniGene; Cel.6144; -.
DR PDB; 1GRW; X-ray; 2.60 A; A/B/C/D=2-127.
DR PDBsum; 1GRW; -.
DR ProteinModelPortal; P53017; -.
DR SMR; P53017; -.
DR BioGrid; 39322; 1.
DR BioGrid; 39324; 1.
DR BioGrid; 56828; 1.
DR DIP; DIP-25397N; -.
DR DIP; DIP-26837N; -.
DR IntAct; P53017; 1.
DR MINT; MINT-1056924; -.
DR STRING; 6239.ZK354.5; -.
DR EPD; P53017; -.
DR PaxDb; P53017; -.
DR PeptideAtlas; P53017; -.
DR PRIDE; P53017; -.
DR EnsemblMetazoa; C33F10.9; C33F10.9; WBGene00003435.
DR EnsemblMetazoa; C34F11.4; C34F11.4; WBGene00003443.
DR EnsemblMetazoa; F36H12.7; F36H12.7; WBGene00003426.
DR EnsemblMetazoa; F58A6.8; F58A6.8; WBGene00003438.
DR EnsemblMetazoa; K05F1.2; K05F1.2; WBGene00003469.
DR EnsemblMetazoa; K07F5.1; K07F5.1; WBGene00003467.
DR EnsemblMetazoa; R05F9.13; R05F9.13; WBGene00003429.
DR EnsemblMetazoa; R13H9.4; R13H9.4; WBGene00003446.
DR EnsemblMetazoa; ZK1248.6; ZK1248.6; WBGene00003457.
DR EnsemblMetazoa; ZK354.1; ZK354.1; WBGene00003458.
DR EnsemblMetazoa; ZK354.11; ZK354.11; WBGene00003452.
DR EnsemblMetazoa; ZK354.4; ZK354.4; WBGene00003468.
DR EnsemblMetazoa; ZK354.5; ZK354.5; WBGene00003444.
DR GeneID; 173830; -.
DR GeneID; 173849; -.
DR GeneID; 173884; -.
DR GeneID; 173890; -.
DR GeneID; 173981; -.
DR GeneID; 173983; -.
DR GeneID; 177275; -.
DR GeneID; 177305; -.
DR GeneID; 177309; -.
DR GeneID; 177311; -.
DR GeneID; 177827; -.
DR GeneID; 191292; -.
DR GeneID; 259801; -.
DR KEGG; cel:CELE_C33F10.9; -.
DR KEGG; cel:CELE_C34F11.4; -.
DR KEGG; cel:CELE_F36H12.7; -.
DR KEGG; cel:CELE_F58A6.8; -.
DR KEGG; cel:CELE_K05F1.2; -.
DR KEGG; cel:CELE_K07F5.1; -.
DR KEGG; cel:CELE_R05F9.13; -.
DR KEGG; cel:CELE_R13H9.4; -.
DR KEGG; cel:CELE_ZK1248.6; -.
DR KEGG; cel:CELE_ZK354.1; -.
DR KEGG; cel:CELE_ZK354.11; -.
DR KEGG; cel:CELE_ZK354.4; -.
DR KEGG; cel:CELE_ZK354.5; -.
DR UCSC; C33F10.9; c. elegans.
DR CTD; 173830; -.
DR CTD; 173849; -.
DR CTD; 173884; -.
DR CTD; 173890; -.
DR CTD; 173981; -.
DR CTD; 173983; -.
DR CTD; 177275; -.
DR CTD; 177305; -.
DR CTD; 177309; -.
DR CTD; 177311; -.
DR CTD; 177827; -.
DR CTD; 191292; -.
DR CTD; 259801; -.
DR WormBase; C33F10.9; CE02806; WBGene00003435; msp-40.
DR WormBase; C34F11.4; CE02806; WBGene00003443; msp-50.
DR WormBase; F36H12.7; CE02806; WBGene00003426; msp-19.
DR WormBase; F58A6.8; CE02806; WBGene00003438; msp-45.
DR WormBase; K05F1.2; CE02806; WBGene00003469; msp-142.
DR WormBase; K07F5.1; CE02806; WBGene00003467; msp-81.
DR WormBase; R05F9.13; CE02806; WBGene00003429; msp-31.
DR WormBase; R13H9.4; CE02806; WBGene00003446; msp-53.
DR WormBase; ZK1248.6; CE02806; WBGene00003457; msp-64.
DR WormBase; ZK354.1; CE02806; WBGene00003458; msp-65.
DR WormBase; ZK354.11; CE02806; WBGene00003452; msp-59.
DR WormBase; ZK354.4; CE02806; WBGene00003468; msp-113.
DR WormBase; ZK354.5; CE02806; WBGene00003444; msp-51.
DR eggNOG; ENOG410JBRH; Eukaryota.
DR eggNOG; ENOG410ZFGP; LUCA.
DR GeneTree; ENSGT00730000111368; -.
DR HOGENOM; HOG000015566; -.
DR InParanoid; P53017; -.
DR OMA; RVFAMAQ; -.
DR OrthoDB; \N; -.
DR PhylomeDB; P53017; -.
DR EvolutionaryTrace; P53017; -.
DR PRO; PR:P53017; -.
DR Proteomes; UP000001940; Chromosome II.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00003426; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0031143; C:pseudopodium; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000535; MSP_dom.
DR InterPro; IPR008962; PapD-like.
DR Pfam; PF00635; Motile_Sperm; 1.
DR SUPFAM; SSF49354; SSF49354; 1.
DR PROSITE; PS50202; MSP; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Cell projection; Complete proteome;
KW Cytoplasm; Cytoskeleton; Reference proteome.
FT INIT_MET 1 1 Removed. {ECO:0000250}.
FT CHAIN 2 127 Major sperm protein
FT 19/31/40/45/50/51/53/59/61/65/81/113/142.
FT /FTId=PRO_0000213437.
FT DOMAIN 9 126 MSP. {ECO:0000255|PROSITE-
FT ProRule:PRU00132}.
FT MOD_RES 2 2 N-acetylalanine. {ECO:0000250}.
FT STRAND 10 16 {ECO:0000244|PDB:1GRW}.
FT STRAND 18 22 {ECO:0000244|PDB:1GRW}.
FT STRAND 28 36 {ECO:0000244|PDB:1GRW}.
FT STRAND 38 40 {ECO:0000244|PDB:1GRW}.
FT STRAND 42 49 {ECO:0000244|PDB:1GRW}.
FT TURN 51 53 {ECO:0000244|PDB:1GRW}.
FT STRAND 54 63 {ECO:0000244|PDB:1GRW}.
FT STRAND 68 75 {ECO:0000244|PDB:1GRW}.
FT HELIX 80 82 {ECO:0000244|PDB:1GRW}.
FT STRAND 89 96 {ECO:0000244|PDB:1GRW}.
FT HELIX 107 110 {ECO:0000244|PDB:1GRW}.
FT STRAND 112 114 {ECO:0000244|PDB:1GRW}.
FT STRAND 117 126 {ECO:0000244|PDB:1GRW}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 9 126 iprf:MSP [T]
FT MYHIT 10 113 ipfam:Motile_Sperm [T]
SQ SEQUENCE 127 AA; 14209 MW; 69F69631BEA5B147 CRC64;
MAQSVPPGDI QTQPGTKIVF NAPYDDKHTY HIKVINSSAR RIGYGIKTTN MKRLGVDPPC
GVLDPKEAVL LAVSCDAFAF GQEDTNNDRI TVEWTNTPDG AAKQFRREWF QGDGMVRRKN
LPIEYNP
//
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