Entry euk:MF14C_HUMAN

ID   MF14C_HUMAN             Reviewed;         134 AA.
AC   Q5VZR4; Q9BSG7;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   15-MAR-2017, entry version 94.
DE   RecName: Full=Hippocampus abundant transcript-like protein 2 {ECO:0000312|HGNC:HGNC:23672};
DE   AltName: Full=Major facilitator superfamily domain-containing 14C {ECO:0000312|HGNC:HGNC:23672};
GN   Name=MFSD14C {ECO:0000312|HGNC:HGNC:23672};
GN   Synonyms=HIATL2 {ECO:0000312|HGNC:HGNC:23672};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA   Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA   Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA   Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA   Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA   Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA   Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA   Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA   Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA   Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA   Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA   McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA   Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA   Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA   Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA   Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA   Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA   Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA   Rogers J., Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-132.
RC   TISSUE=Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BC005058; Type=Miscellaneous discrepancy; Note=The sequence differs at the 3' end.; Evidence={ECO:0000305};
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DR   EMBL; AL158827; CAH72564.1; -; Genomic_DNA.
DR   EMBL; AL445670; CAH72564.1; JOINED; Genomic_DNA.
DR   EMBL; AL445670; CAI15052.1; -; Genomic_DNA.
DR   EMBL; AL158827; CAI15052.1; JOINED; Genomic_DNA.
DR   EMBL; BC005058; -; NOT_ANNOTATED_CDS; mRNA.
DR   UniGene; Hs.610084; -.
DR   ProteinModelPortal; Q5VZR4; -.
DR   IntAct; Q5VZR4; 1.
DR   iPTMnet; Q5VZR4; -.
DR   PhosphoSitePlus; Q5VZR4; -.
DR   MaxQB; Q5VZR4; -.
DR   PaxDb; Q5VZR4; -.
DR   PeptideAtlas; Q5VZR4; -.
DR   PRIDE; Q5VZR4; -.
DR   Ensembl; ENST00000375223; ENSP00000364371; ENSG00000196312.
DR   UCSC; uc064upl.1; human.
DR   GeneCards; MFSD14C; -.
DR   HGNC; HGNC:23672; MFSD14C.
DR   neXtProt; NX_Q5VZR4; -.
DR   eggNOG; KOG2816; Eukaryota.
DR   eggNOG; ENOG410ZVCA; LUCA.
DR   GeneTree; ENSGT00510000046502; -.
DR   HOGENOM; HOG000206711; -.
DR   InParanoid; Q5VZR4; -.
DR   PhylomeDB; Q5VZR4; -.
DR   PRO; PR:Q5VZR4; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   Bgee; ENSG00000196312; -.
DR   CleanEx; HS_HIATL2; -.
DR   ExpressionAtlas; Q5VZR4; baseline and differential.
DR   Genevisible; Q5VZR4; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005215; F:transporter activity; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN         1    134       Hippocampus abundant transcript-like
FT                                protein 2.
FT                                /FTId=PRO_0000239231.
FT   TOPO_DOM      1     49       Extracellular. {ECO:0000255}.
FT   TRANSMEM     50     70       Helical. {ECO:0000255}.
FT   TOPO_DOM     71     82       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     83    103       Helical. {ECO:0000255}.
FT   TOPO_DOM    104    111       Extracellular. {ECO:0000255}.
FT   TRANSMEM    112    132       Helical. {ECO:0000255}.
FT   TOPO_DOM    133    134       Cytoplasmic. {ECO:0000255}.
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CC   The following FT lines are automated annotations from the MyHits database.
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FT   MYHIT        44    134       iprf:MFS [T]
FT   MYHIT       100    116       ipat:SUGAR_TRANSPORT_1 [T]
SQ   SEQUENCE   134 AA;  14477 MW;  453019488F8F542E CRC64;
     MSVEPPPELE EKAASEPEAG AMPEKRAGAQ AAGSTWLQGF GPPSVYHAAI VIFLEFFAWG
     LLTTPMLTVL HETFSQHTFL MNGLIQGVKG LLSFLSAPLI GALSDVWGRK PFLLGTVFFT
     CFPIPLMRIS PCQA
//