ID MF14C_HUMAN Reviewed; 134 AA.
AC Q5VZR4; Q9BSG7;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 15-MAR-2017, entry version 94.
DE RecName: Full=Hippocampus abundant transcript-like protein 2 {ECO:0000312|HGNC:HGNC:23672};
DE AltName: Full=Major facilitator superfamily domain-containing 14C {ECO:0000312|HGNC:HGNC:23672};
GN Name=MFSD14C {ECO:0000312|HGNC:HGNC:23672};
GN Synonyms=HIATL2 {ECO:0000312|HGNC:HGNC:23672};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA Rogers J., Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-132.
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BC005058; Type=Miscellaneous discrepancy; Note=The sequence differs at the 3' end.; Evidence={ECO:0000305};
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DR EMBL; AL158827; CAH72564.1; -; Genomic_DNA.
DR EMBL; AL445670; CAH72564.1; JOINED; Genomic_DNA.
DR EMBL; AL445670; CAI15052.1; -; Genomic_DNA.
DR EMBL; AL158827; CAI15052.1; JOINED; Genomic_DNA.
DR EMBL; BC005058; -; NOT_ANNOTATED_CDS; mRNA.
DR UniGene; Hs.610084; -.
DR ProteinModelPortal; Q5VZR4; -.
DR IntAct; Q5VZR4; 1.
DR iPTMnet; Q5VZR4; -.
DR PhosphoSitePlus; Q5VZR4; -.
DR MaxQB; Q5VZR4; -.
DR PaxDb; Q5VZR4; -.
DR PeptideAtlas; Q5VZR4; -.
DR PRIDE; Q5VZR4; -.
DR Ensembl; ENST00000375223; ENSP00000364371; ENSG00000196312.
DR UCSC; uc064upl.1; human.
DR GeneCards; MFSD14C; -.
DR HGNC; HGNC:23672; MFSD14C.
DR neXtProt; NX_Q5VZR4; -.
DR eggNOG; KOG2816; Eukaryota.
DR eggNOG; ENOG410ZVCA; LUCA.
DR GeneTree; ENSGT00510000046502; -.
DR HOGENOM; HOG000206711; -.
DR InParanoid; Q5VZR4; -.
DR PhylomeDB; Q5VZR4; -.
DR PRO; PR:Q5VZR4; -.
DR Proteomes; UP000005640; Chromosome 9.
DR Bgee; ENSG00000196312; -.
DR CleanEx; HS_HIATL2; -.
DR ExpressionAtlas; Q5VZR4; baseline and differential.
DR Genevisible; Q5VZR4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005215; F:transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1 134 Hippocampus abundant transcript-like
FT protein 2.
FT /FTId=PRO_0000239231.
FT TOPO_DOM 1 49 Extracellular. {ECO:0000255}.
FT TRANSMEM 50 70 Helical. {ECO:0000255}.
FT TOPO_DOM 71 82 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 83 103 Helical. {ECO:0000255}.
FT TOPO_DOM 104 111 Extracellular. {ECO:0000255}.
FT TRANSMEM 112 132 Helical. {ECO:0000255}.
FT TOPO_DOM 133 134 Cytoplasmic. {ECO:0000255}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 44 134 iprf:MFS [T]
FT MYHIT 100 116 ipat:SUGAR_TRANSPORT_1 [T]
SQ SEQUENCE 134 AA; 14477 MW; 453019488F8F542E CRC64;
MSVEPPPELE EKAASEPEAG AMPEKRAGAQ AAGSTWLQGF GPPSVYHAAI VIFLEFFAWG
LLTTPMLTVL HETFSQHTFL MNGLIQGVKG LLSFLSAPLI GALSDVWGRK PFLLGTVFFT
CFPIPLMRIS PCQA
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