ID M0R5T3_RAT Unreviewed; 518 AA.
AC M0R5T3;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 10-MAY-2017, entry version 34.
DE SubName: Full=RCG44245 {ECO:0000313|EMBL:EDL82812.1};
DE SubName: Full=Zinc finger protein 449 {ECO:0000313|Ensembl:ENSRNOP00000064761};
GN Name=Zfp449 {ECO:0000313|Ensembl:ENSRNOP00000064761,
GN ECO:0000313|RGD:1584453};
GN Synonyms=LOC684901 {ECO:0000313|RGD:1584453};
GN ORFNames=rCG_44245 {ECO:0000313|EMBL:EDL82812.1};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000064761, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000064761, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000064761,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into
RT mammalian evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|EMBL:EDL82812.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BN {ECO:0000313|EMBL:EDL82812.1};
RX PubMed=15632090; DOI=10.1101/gr.2889405;
RA Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
RA Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
RA Istrail S., Li P., Sutton G.;
RT "Gene and alternative splicing annotation with AIR.";
RL Genome Res. 15:54-66(2005).
RN [3] {ECO:0000313|EMBL:EDL82812.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BN {ECO:0000313|EMBL:EDL82812.1};
RA Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
RA Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
RA Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L.,
RA Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C.,
RA Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSRNOP00000064761}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000064761};
RG Ensembl;
RL Submitted (FEB-2013) to UniProtKB.
RN [5] {ECO:0000313|Ensembl:ENSRNOP00000068145}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000068145};
RG Ensembl;
RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-
CC ProRule:PRU00187, ECO:0000256|SAAS:SAAS00772597}.
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DR EMBL; AABR07039295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR07039296; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH474219; EDL82812.1; -; Genomic_DNA.
DR RefSeq; XP_001072386.1; XM_001072386.6.
DR RefSeq; XP_003752124.1; XM_003752076.4.
DR STRING; 10116.ENSRNOP00000064761; -.
DR Ensembl; ENSRNOT00000073827; ENSRNOP00000064761; ENSRNOG00000050562.
DR Ensembl; ENSRNOT00000077002; ENSRNOP00000068145; ENSRNOG00000050562.
DR GeneID; 684901; -.
DR KEGG; rno:684901; -.
DR CTD; 78619; -.
DR RGD; 1584453; Zfp449.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00730000110971; -.
DR KO; K09230; -.
DR OMA; PVAEAWI; -.
DR OrthoDB; EOG091G02KC; -.
DR Proteomes; UP000002494; Chromosome X.
DR Bgee; ENSRNOG00000050562; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR008916; Retrov_capsid_C.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF02023; SCAN; 1.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF47353; SSF47353; 1.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 4: Predicted;
KW Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW Metal-binding {ECO:0000256|SAAS:SAAS00772615};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187,
KW ECO:0000256|SAAS:SAAS00772585};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Repeat {ECO:0000256|SAAS:SAAS00772661};
KW Transcription {ECO:0000256|SAAS:SAAS00772592};
KW Transcription regulation {ECO:0000256|SAAS:SAAS00772592};
KW Zinc {ECO:0000256|SAAS:SAAS00772615};
KW Zinc-finger {ECO:0000256|SAAS:SAAS00772615}.
FT DOMAIN 30 112 SCAN box. {ECO:0000259|PROSITE:PS50804}.
FT DOMAIN 323 350 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 351 378 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 379 406 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 407 434 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 435 462 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 463 490 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
FT DOMAIN 491 513 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
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CC The following FT lines are automated annotations from the MyHits database.
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FT MYHIT 463 485 ismart:ZnF_C2H2 [T]
FT MYHIT 353 373 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 379 406 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 407 434 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 409 429 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 435 457 ismart:ZnF_C2H2 [T]
FT MYHIT 437 457 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 381 401 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 465 485 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 325 345 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 351 373 ismart:ZnF_C2H2 [T]
FT MYHIT 463 490 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 379 401 ismart:ZnF_C2H2 [T]
FT MYHIT 323 350 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 491 513 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 491 513 ismart:ZnF_C2H2 [T]
FT MYHIT 435 462 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 27 113 ipfam:SCAN [T]
FT MYHIT 351 378 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 26 134 ismart:SCAN [T]
FT MYHIT 30 112 iprf:SCAN_BOX [T]
FT MYHIT 493 513 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 323 345 ismart:ZnF_C2H2 [T]
FT MYHIT 407 429 ismart:ZnF_C2H2 [T]
SQ SEQUENCE 518 AA; 59973 MW; CFF07AEBE304E060 CRC64;
MAVALGRAIQ ASLNQGSVLQ EYDTDCEVFR QRFRQFQYTE AAGPHEAFNK LWELCCQWLK
PKMRSKEQIL ELLVLEQFLT ILPTEIETWV REHCPDNRER VVSLIEDLQR ELEIPEPQID
MDDMLLEELA PVGTVPMPPN LHLEEPSLQV MAPVQEPPVP DAWIPQAGPQ DLNYSTDGEC
QSFLDPGYQL PKLDMNFPLD HREEPWVKDL EDPKEMKQLL DSKIGFEMGI ENEEDASKQK
KLENLYPFVV TLEGNALHGP ILQKDYVQLE NEWETSPEDL QTDLTKLVDP QNPTLGETPE
NPDLEEPLNP KPPKKKSPGD KPHRCPQCGK CFARKSQLTG HQRIHSGEEP HKCPECGKRF
LRSSDLYRHQ RLHTGERPYE CTVCKKRFTR RSHLLGHQRT HSEEETYKCL ECGKSFCHGS
SLKRHLKTHT GEKPHRCHNC GKSFSRLTAL TLHQRTHTEE RPFKCSYCGK SFRQRPSLVI
HLRIHTGEKP YKCTHCSKSF RQRAGLIMHQ VTHFRGLL
//
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